Retrospective cohort study of lassa fever in pregnancy, southern nigeria

Sylvanus Okogbenin; Joseph Okoeguale; Ped George Akpede; Andres Colubri; Kayla Barnes; Samar Mehta; Reuben Eifediyi; Felix Okogbo; Joseph Eigbefoh; Mojeed Momoh; Mojeed Rafiu; Donatus Adomeh; Ikponmwosa Odia; Chris Aire; Rebecca Atafo; Martha Okonofua; Meike Pahlman; Beate Becker Ziaja; Danny Asogun; Peter Okokhere; Christian Happi; Stephan Günther; Pardis C. Sabeti; Ephraim Ogbaini-Emovon

doi:10.3201/eid2508.181299

Retrospective cohort study of lassa fever in pregnancy, southern nigeria

Sylvanus Okogbenin, Joseph Okoeguale, Ped George Akpede, Andres Colubri, Kayla Barnes, Samar Mehta, Reuben Eifediyi, Felix Okogbo, Joseph Eigbefoh, Mojeed Momoh, Mojeed Rafiu, Donatus Adomeh, Ikponmwosa Odia, Chris Aire, Rebecca Atafo, Martha Okonofua, Meike Pahlman, Beate Becker Ziaja, Danny Asogun, Peter OkokhereChristian Happi, Stephan Günther, Pardis C. Sabeti, Ephraim Ogbaini-Emovon

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Abstract

Lassa fever in pregnancy causes high rates of maternal and fetal death, but limited data are available to guide clinicians. We retrospectively studied 30 pregnant Lassa fever patients treated with early ribavirin therapy and a conservative obstetric approach at a teaching hospital in southern Nigeria during January 2009–March 2018. Eleven (36.7%) of 30 women died, and 20/31 (64.5%) pregnancies ended in fetal or perinatal loss. On initial evaluation, 17/30 (56.6%) women had a dead fetus; 10/17 (58.8%) of these patients died, compared with 1/13 (7.7%) of women with a live fetus. Extravaginal bleeding, convulsions, and oliguria each were independently associated with maternal and fetal or perinatal death, whereas seeking care in the third trimester was not. For women with a live fetus at initial evaluation, the positive outcomes observed contrast with previous reports, and they support a conservative approach to obstetric management of Lassa fever in pregnancy in Nigeria.

Original language	English
Pages (from-to)	1495-1500
Number of pages	6
Journal	Emerging Infectious Diseases
Volume	25
Issue number	8
DOIs	https://doi.org/10.3201/eid2508.181299
Publication status	Published - 1 Aug 2019
Externally published	Yes

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Okogbenin, S., Okoeguale, J., Akpede, P. G., Colubri, A., Barnes, K., Mehta, S., Eifediyi, R., Okogbo, F., Eigbefoh, J., Momoh, M., Rafiu, M., Adomeh, D., Odia, I., Aire, C., Atafo, R., Okonofua, M., Pahlman, M., Ziaja, B. B., Asogun, D., ... Ogbaini-Emovon, E. (2019). Retrospective cohort study of lassa fever in pregnancy, southern nigeria. Emerging Infectious Diseases, 25(8), 1495-1500. https://doi.org/10.3201/eid2508.181299

@article{4c9f16d647424aff98978be83a4ce6c4,

title = "Retrospective cohort study of lassa fever in pregnancy, southern nigeria",

abstract = "Lassa fever in pregnancy causes high rates of maternal and fetal death, but limited data are available to guide clinicians. We retrospectively studied 30 pregnant Lassa fever patients treated with early ribavirin therapy and a conservative obstetric approach at a teaching hospital in southern Nigeria during January 2009–March 2018. Eleven (36.7\%) of 30 women died, and 20/31 (64.5\%) pregnancies ended in fetal or perinatal loss. On initial evaluation, 17/30 (56.6\%) women had a dead fetus; 10/17 (58.8\%) of these patients died, compared with 1/13 (7.7\%) of women with a live fetus. Extravaginal bleeding, convulsions, and oliguria each were independently associated with maternal and fetal or perinatal death, whereas seeking care in the third trimester was not. For women with a live fetus at initial evaluation, the positive outcomes observed contrast with previous reports, and they support a conservative approach to obstetric management of Lassa fever in pregnancy in Nigeria.",

author = "Sylvanus Okogbenin and Joseph Okoeguale and Akpede, \{Ped George\} and Andres Colubri and Kayla Barnes and Samar Mehta and Reuben Eifediyi and Felix Okogbo and Joseph Eigbefoh and Mojeed Momoh and Mojeed Rafiu and Donatus Adomeh and Ikponmwosa Odia and Chris Aire and Rebecca Atafo and Martha Okonofua and Meike Pahlman and Ziaja, \{Beate Becker\} and Danny Asogun and Peter Okokhere and Christian Happi and Stephan G{\"u}nther and Sabeti, \{Pardis C.\} and Ephraim Ogbaini-Emovon",

year = "2019",

month = aug,

day = "1",

doi = "10.3201/eid2508.181299",

language = "English",

volume = "25",

pages = "1495--1500",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

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Okogbenin, S, Okoeguale, J, Akpede, PG, Colubri, A, Barnes, K, Mehta, S, Eifediyi, R, Okogbo, F, Eigbefoh, J, Momoh, M, Rafiu, M, Adomeh, D, Odia, I, Aire, C, Atafo, R, Okonofua, M, Pahlman, M, Ziaja, BB, Asogun, D, Okokhere, P, Happi, C, Günther, S, Sabeti, PC & Ogbaini-Emovon, E 2019, 'Retrospective cohort study of lassa fever in pregnancy, southern nigeria', Emerging Infectious Diseases, vol. 25, no. 8, pp. 1495-1500. https://doi.org/10.3201/eid2508.181299

TY - JOUR

T1 - Retrospective cohort study of lassa fever in pregnancy, southern nigeria

AU - Okogbenin, Sylvanus

AU - Okoeguale, Joseph

AU - Akpede, Ped George

AU - Colubri, Andres

AU - Barnes, Kayla

AU - Mehta, Samar

AU - Eifediyi, Reuben

AU - Okogbo, Felix

AU - Eigbefoh, Joseph

AU - Momoh, Mojeed

AU - Rafiu, Mojeed

AU - Adomeh, Donatus

AU - Odia, Ikponmwosa

AU - Aire, Chris

AU - Atafo, Rebecca

AU - Okonofua, Martha

AU - Pahlman, Meike

AU - Ziaja, Beate Becker

AU - Asogun, Danny

AU - Okokhere, Peter

AU - Happi, Christian

AU - Günther, Stephan

AU - Sabeti, Pardis C.

AU - Ogbaini-Emovon, Ephraim

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Lassa fever in pregnancy causes high rates of maternal and fetal death, but limited data are available to guide clinicians. We retrospectively studied 30 pregnant Lassa fever patients treated with early ribavirin therapy and a conservative obstetric approach at a teaching hospital in southern Nigeria during January 2009–March 2018. Eleven (36.7%) of 30 women died, and 20/31 (64.5%) pregnancies ended in fetal or perinatal loss. On initial evaluation, 17/30 (56.6%) women had a dead fetus; 10/17 (58.8%) of these patients died, compared with 1/13 (7.7%) of women with a live fetus. Extravaginal bleeding, convulsions, and oliguria each were independently associated with maternal and fetal or perinatal death, whereas seeking care in the third trimester was not. For women with a live fetus at initial evaluation, the positive outcomes observed contrast with previous reports, and they support a conservative approach to obstetric management of Lassa fever in pregnancy in Nigeria.

AB - Lassa fever in pregnancy causes high rates of maternal and fetal death, but limited data are available to guide clinicians. We retrospectively studied 30 pregnant Lassa fever patients treated with early ribavirin therapy and a conservative obstetric approach at a teaching hospital in southern Nigeria during January 2009–March 2018. Eleven (36.7%) of 30 women died, and 20/31 (64.5%) pregnancies ended in fetal or perinatal loss. On initial evaluation, 17/30 (56.6%) women had a dead fetus; 10/17 (58.8%) of these patients died, compared with 1/13 (7.7%) of women with a live fetus. Extravaginal bleeding, convulsions, and oliguria each were independently associated with maternal and fetal or perinatal death, whereas seeking care in the third trimester was not. For women with a live fetus at initial evaluation, the positive outcomes observed contrast with previous reports, and they support a conservative approach to obstetric management of Lassa fever in pregnancy in Nigeria.

U2 - 10.3201/eid2508.181299

DO - 10.3201/eid2508.181299

M3 - Article

SN - 1080-6040

VL - 25

SP - 1495

EP - 1500

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 8

ER -

Retrospective cohort study of lassa fever in pregnancy, southern nigeria

Abstract

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