Research strategies to improve snakebite treatment: challenges and progress.

Robert Harrison; Darren A. Cook; Camila Renjifo; Nick Casewell; Rachel B. Currier; Simon Wagstaff

doi:10.1016/j.jprot.2011.06.019

Research strategies to improve snakebite treatment: challenges and progress.

Robert Harrison, Darren A. Cook, Camila Renjifo, Nick Casewell, Rachel B. Currier, Simon Wagstaff

Tropical Disease Biology

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Review article › peer-review

77 Citations (Scopus)

Abstract

Antivenom is an effective treatment of snakebite but, because of the complex interplay of fiscal, epidemiological, therapeutic efficacy and safety issues, the mortality of snakebite remains unacceptably high. Efficiently combating this high level of preventable death amongst the world's most disadvantaged communities requires the globally-coordinated action of multiple intervention programmes. This is the overall objective of the Global Snakebite Initiative. This paper describes the challenges facing the research community to develop snakebite treatments that are more efficacious, safe and affordable than current therapy.

Original language	English
Pages (from-to)	1768-1780
Number of pages	13
Journal	Journal of Proteomics
Volume	74
Issue number	9
DOIs	https://doi.org/10.1016/j.jprot.2011.06.019
Publication status	Published - 24 Aug 2011

Keywords

Antivenom affordability
Camelid IgG/VHH
Epitope-string immunogen
Global Snakebite Initiative
Snake
Venom gland transcriptome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jprot.2011.06.019

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title = "Research strategies to improve snakebite treatment: challenges and progress.",

abstract = "Antivenom is an effective treatment of snakebite but, because of the complex interplay of fiscal, epidemiological, therapeutic efficacy and safety issues, the mortality of snakebite remains unacceptably high. Efficiently combating this high level of preventable death amongst the world's most disadvantaged communities requires the globally-coordinated action of multiple intervention programmes. This is the overall objective of the Global Snakebite Initiative. This paper describes the challenges facing the research community to develop snakebite treatments that are more efficacious, safe and affordable than current therapy.",

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T1 - Research strategies to improve snakebite treatment: challenges and progress.

AU - Harrison, Robert

AU - Cook, Darren A.

AU - Renjifo, Camila

AU - Casewell, Nick

AU - Currier, Rachel B.

AU - Wagstaff, Simon

PY - 2011/8/24

Y1 - 2011/8/24

N2 - Antivenom is an effective treatment of snakebite but, because of the complex interplay of fiscal, epidemiological, therapeutic efficacy and safety issues, the mortality of snakebite remains unacceptably high. Efficiently combating this high level of preventable death amongst the world's most disadvantaged communities requires the globally-coordinated action of multiple intervention programmes. This is the overall objective of the Global Snakebite Initiative. This paper describes the challenges facing the research community to develop snakebite treatments that are more efficacious, safe and affordable than current therapy.

AB - Antivenom is an effective treatment of snakebite but, because of the complex interplay of fiscal, epidemiological, therapeutic efficacy and safety issues, the mortality of snakebite remains unacceptably high. Efficiently combating this high level of preventable death amongst the world's most disadvantaged communities requires the globally-coordinated action of multiple intervention programmes. This is the overall objective of the Global Snakebite Initiative. This paper describes the challenges facing the research community to develop snakebite treatments that are more efficacious, safe and affordable than current therapy.

KW - Antivenom affordability

KW - Camelid IgG/VHH

KW - Epitope-string immunogen

KW - Global Snakebite Initiative

KW - Snake

KW - Venom gland transcriptome

U2 - 10.1016/j.jprot.2011.06.019

DO - 10.1016/j.jprot.2011.06.019

M3 - Review article

SN - 1874-3919

VL - 74

SP - 1768

EP - 1780

JO - Journal of Proteomics

JF - Journal of Proteomics

IS - 9

ER -

Research strategies to improve snakebite treatment: challenges and progress.

Abstract

Keywords

UN SDGs

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