Reply to Dr. Lai regarding Allopurinol Hypersensitivity Syndrome in patients of Asian ancestry

Charles A Hay; James Prior; Christian D Mallen; John Belcher; Ed Roddy

doi:10.1002/acr.24777

Reply to Dr. Lai regarding Allopurinol Hypersensitivity Syndrome in patients of Asian ancestry

Charles A Hay, James Prior, Christian D Mallen, John Belcher, Ed Roddy

International Public Health

Research output: Contribution to journal › Letter › peer-review

Abstract

We thank Dr Lai for their interest in our study (1). While we did not show a statistically significant link between the use of allopurinol and mortality in people with gout, we agree that Allopurinol Hypersensitivity Syndrome (AHS) is the most serious side-effect of allopurinol, particularly in populations with South East Asian ancestry, leading to the recommendation to screen people of South East Asian descent for the HLA-B*5801 allele prior to starting treatment with allopurinol (2,3).

Original language	English
Pages (from-to)	161-162
Number of pages	2
Journal	Arthritis Care and Research
Volume	74
Issue number	1
Early online date	3 Sept 2021
DOIs	https://doi.org/10.1002/acr.24777
Publication status	Published - 1 Jan 2022

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title = "Reply to Dr. Lai regarding Allopurinol Hypersensitivity Syndrome in patients of Asian ancestry",

abstract = "We thank Dr Lai for their interest in our study (1). While we did not show a statistically significant link between the use of allopurinol and mortality in people with gout, we agree that Allopurinol Hypersensitivity Syndrome (AHS) is the most serious side-effect of allopurinol, particularly in populations with South East Asian ancestry, leading to the recommendation to screen people of South East Asian descent for the HLA-B*5801 allele prior to starting treatment with allopurinol (2,3).",

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AU - Hay, Charles A

AU - Prior, James

AU - Mallen, Christian D

AU - Belcher, John

AU - Roddy, Ed

PY - 2022/1/1

Y1 - 2022/1/1

N2 - We thank Dr Lai for their interest in our study (1). While we did not show a statistically significant link between the use of allopurinol and mortality in people with gout, we agree that Allopurinol Hypersensitivity Syndrome (AHS) is the most serious side-effect of allopurinol, particularly in populations with South East Asian ancestry, leading to the recommendation to screen people of South East Asian descent for the HLA-B*5801 allele prior to starting treatment with allopurinol (2,3).

AB - We thank Dr Lai for their interest in our study (1). While we did not show a statistically significant link between the use of allopurinol and mortality in people with gout, we agree that Allopurinol Hypersensitivity Syndrome (AHS) is the most serious side-effect of allopurinol, particularly in populations with South East Asian ancestry, leading to the recommendation to screen people of South East Asian descent for the HLA-B*5801 allele prior to starting treatment with allopurinol (2,3).

U2 - 10.1002/acr.24777

DO - 10.1002/acr.24777

M3 - Letter

SN - 2151-464X

VL - 74

SP - 161

EP - 162

JO - Arthritis Care and Research

JF - Arthritis Care and Research

IS - 1

ER -

Reply to Dr. Lai regarding Allopurinol Hypersensitivity Syndrome in patients of Asian ancestry

Abstract

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