Reliability of rapid testing for hepatitis B in a region of high HIV endemicity

J. Davies; J. J.G. van Oosterhout; M. Nyirenda; J. Bowden; E. Moore; I. J. Hart; E. E. Zijlstra; M. Chaponda; B. Faragher; Nicholas Beeching; M. B.J. Beadsworth

doi:10.1016/j.trstmh.2009.10.010

Reliability of rapid testing for hepatitis B in a region of high HIV endemicity

J. Davies, J. J.G. van Oosterhout, M. Nyirenda, J. Bowden, E. Moore, I. J. Hart, E. E. Zijlstra, M. Chaponda, B. Faragher, Nicholas Beeching, M. B.J. Beadsworth

Clinical Sciences and International Public Health

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Hepatitis B (HBV) and HIV co-infection is common in resource-poor settings. A recent study from Malawi revealed poor correlation between hepatitis B surface antigen (HBsAg) point-of-care tests and reference tests in patients co-infected with HIV. We studied a cohort of 300 Malawian adults entering a treatment programme for HIV. Sera were tested for HBsAg first using the Determine rapid test and re-tested using a commercial enzyme immunoassay (EIA). All tests were done under optimal conditions in Liverpool, UK. Sera from all 25 patients positive for HBsAg using the rapid test and from 50 who were negative, were re-tested using the EIA, with complete concordance of results. The κ correlation was 1, specificity 100% (93–100%) and sensitivity 100% (86–100%) compared to the reference test. Patients had advanced immune suppression (mean CD4 = 175 cells × 106/l). In a non-field setting, the results of point-of-care Determine rapid hepatitis B tests appear reliable in patients with HIV-1 co-infection.

Original language	English
Pages (from-to)	162-164
Number of pages	3
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	104
Issue number	2
DOIs	https://doi.org/10.1016/j.trstmh.2009.10.010
Publication status	Published - 1 Feb 2010

Keywords

Co-infection
Diagnosis
Hepatitis B
HIV
Malawi
Point-of-care test

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.trstmh.2009.10.010

Cite this

Davies, J., van Oosterhout, J. J. G., Nyirenda, M., Bowden, J., Moore, E., Hart, I. J., Zijlstra, E. E., Chaponda, M., Faragher, B., Beeching, N., & Beadsworth, M. B. J. (2010). Reliability of rapid testing for hepatitis B in a region of high HIV endemicity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(2), 162-164. https://doi.org/10.1016/j.trstmh.2009.10.010

@article{68b9f98575194f79956af61d4ce52c74,

title = "Reliability of rapid testing for hepatitis B in a region of high HIV endemicity",

abstract = "Hepatitis B (HBV) and HIV co-infection is common in resource-poor settings. A recent study from Malawi revealed poor correlation between hepatitis B surface antigen (HBsAg) point-of-care tests and reference tests in patients co-infected with HIV. We studied a cohort of 300 Malawian adults entering a treatment programme for HIV. Sera were tested for HBsAg first using the Determine rapid test and re-tested using a commercial enzyme immunoassay (EIA). All tests were done under optimal conditions in Liverpool, UK. Sera from all 25 patients positive for HBsAg using the rapid test and from 50 who were negative, were re-tested using the EIA, with complete concordance of results. The κ correlation was 1, specificity 100\% (93–100\%) and sensitivity 100\% (86–100\%) compared to the reference test. Patients had advanced immune suppression (mean CD4 = 175 cells × 106/l). In a non-field setting, the results of point-of-care Determine rapid hepatitis B tests appear reliable in patients with HIV-1 co-infection.",

keywords = "Co-infection, Diagnosis, Hepatitis B, HIV, Malawi, Point-of-care test",

author = "J. Davies and \{van Oosterhout\}, \{J. J.G.\} and M. Nyirenda and J. Bowden and E. Moore and Hart, \{I. J.\} and Zijlstra, \{E. E.\} and M. Chaponda and B. Faragher and Nicholas Beeching and Beadsworth, \{M. B.J.\}",

year = "2010",

month = feb,

day = "1",

doi = "10.1016/j.trstmh.2009.10.010",

language = "English",

volume = "104",

pages = "162--164",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

issn = "0035-9203",

publisher = "Oxford University Press",

number = "2",

}

Davies, J, van Oosterhout, JJG, Nyirenda, M, Bowden, J, Moore, E, Hart, IJ, Zijlstra, EE, Chaponda, M, Faragher, B, Beeching, N & Beadsworth, MBJ 2010, 'Reliability of rapid testing for hepatitis B in a region of high HIV endemicity', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 104, no. 2, pp. 162-164. https://doi.org/10.1016/j.trstmh.2009.10.010

TY - JOUR

T1 - Reliability of rapid testing for hepatitis B in a region of high HIV endemicity

AU - Davies, J.

AU - van Oosterhout, J. J.G.

AU - Nyirenda, M.

AU - Bowden, J.

AU - Moore, E.

AU - Hart, I. J.

AU - Zijlstra, E. E.

AU - Chaponda, M.

AU - Faragher, B.

AU - Beeching, Nicholas

AU - Beadsworth, M. B.J.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Hepatitis B (HBV) and HIV co-infection is common in resource-poor settings. A recent study from Malawi revealed poor correlation between hepatitis B surface antigen (HBsAg) point-of-care tests and reference tests in patients co-infected with HIV. We studied a cohort of 300 Malawian adults entering a treatment programme for HIV. Sera were tested for HBsAg first using the Determine rapid test and re-tested using a commercial enzyme immunoassay (EIA). All tests were done under optimal conditions in Liverpool, UK. Sera from all 25 patients positive for HBsAg using the rapid test and from 50 who were negative, were re-tested using the EIA, with complete concordance of results. The κ correlation was 1, specificity 100% (93–100%) and sensitivity 100% (86–100%) compared to the reference test. Patients had advanced immune suppression (mean CD4 = 175 cells × 106/l). In a non-field setting, the results of point-of-care Determine rapid hepatitis B tests appear reliable in patients with HIV-1 co-infection.

AB - Hepatitis B (HBV) and HIV co-infection is common in resource-poor settings. A recent study from Malawi revealed poor correlation between hepatitis B surface antigen (HBsAg) point-of-care tests and reference tests in patients co-infected with HIV. We studied a cohort of 300 Malawian adults entering a treatment programme for HIV. Sera were tested for HBsAg first using the Determine rapid test and re-tested using a commercial enzyme immunoassay (EIA). All tests were done under optimal conditions in Liverpool, UK. Sera from all 25 patients positive for HBsAg using the rapid test and from 50 who were negative, were re-tested using the EIA, with complete concordance of results. The κ correlation was 1, specificity 100% (93–100%) and sensitivity 100% (86–100%) compared to the reference test. Patients had advanced immune suppression (mean CD4 = 175 cells × 106/l). In a non-field setting, the results of point-of-care Determine rapid hepatitis B tests appear reliable in patients with HIV-1 co-infection.

KW - Co-infection

KW - Diagnosis

KW - Hepatitis B

KW - HIV

KW - Malawi

KW - Point-of-care test

U2 - 10.1016/j.trstmh.2009.10.010

DO - 10.1016/j.trstmh.2009.10.010

M3 - Article

SN - 0035-9203

VL - 104

SP - 162

EP - 164

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 2

ER -

Reliability of rapid testing for hepatitis B in a region of high HIV endemicity

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this