Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept: Proof of Concept

Kavita Vedhara; Kieran Ayling; Ru Jia; Lucy Fairclough; Joanne R. Morling; Jonathan Ball; Holly Knight; Holly Blake; Jessica Corner; Chris Denning; Kirsty Bolton; Hannah Jackson; Carol Coupland; Patrick Tighe

doi:10.1093/infdis/jiac006

Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept: Proof of Concept

Kavita Vedhara, Kieran Ayling, Ru Jia, Lucy Fairclough, Joanne R. Morling, Jonathan Ball, Holly Knight, Holly Blake, Jessica Corner, Chris Denning, Kirsty Bolton, Hannah Jackson, Carol Coupland, Patrick Tighe

University of Nottingham

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background: Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Participants (n=102) completed measures of anxiety, depression, positive mood, and loneliness and provided a blood sample for the measurement of antibodies to the SARS-CoV-2 spike and nucleocapsid proteins. Results: SARS-CoV-2 was significantly negatively associated with anxiety and depression. The model remained significant after adjustment for age and gender, although anxiety and depression were no longer significant independent predictors. Conclusions: These findings offer early support for the hypothesis that psychological factors may influence susceptibility to SARS-CoV-2 infection.

Original language	English
Pages (from-to)	2137-2141
Number of pages	5
Journal	Journal of Infectious Disease
Volume	225
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiac006
Publication status	Published - 15 Jun 2022
Externally published	Yes

Keywords

antibodies
anxiety
COVID-19
depression
SARS-CoV-2

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10.1093/infdis/jiac006Licence: CC BY

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Vedhara, K., Ayling, K., Jia, R., Fairclough, L., Morling, J. R., Ball, J., Knight, H., Blake, H., Corner, J., Denning, C., Bolton, K., Jackson, H., Coupland, C., & Tighe, P. (2022). Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept: Proof of Concept. Journal of Infectious Disease, 225(12), 2137-2141. https://doi.org/10.1093/infdis/jiac006

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title = "Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept: Proof of Concept",

abstract = "Background: Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Participants (n=102) completed measures of anxiety, depression, positive mood, and loneliness and provided a blood sample for the measurement of antibodies to the SARS-CoV-2 spike and nucleocapsid proteins. Results: SARS-CoV-2 was significantly negatively associated with anxiety and depression. The model remained significant after adjustment for age and gender, although anxiety and depression were no longer significant independent predictors. Conclusions: These findings offer early support for the hypothesis that psychological factors may influence susceptibility to SARS-CoV-2 infection.",

keywords = "antibodies, anxiety, COVID-19, depression, SARS-CoV-2",

author = "Kavita Vedhara and Kieran Ayling and Ru Jia and Lucy Fairclough and Morling, \{Joanne R.\} and Jonathan Ball and Holly Knight and Holly Blake and Jessica Corner and Chris Denning and Kirsty Bolton and Hannah Jackson and Carol Coupland and Patrick Tighe",

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month = jun,

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doi = "10.1093/infdis/jiac006",

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Vedhara, K, Ayling, K, Jia, R, Fairclough, L, Morling, JR, Ball, J, Knight, H, Blake, H, Corner, J, Denning, C, Bolton, K, Jackson, H, Coupland, C & Tighe, P 2022, 'Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept: Proof of Concept', Journal of Infectious Disease, vol. 225, no. 12, pp. 2137-2141. https://doi.org/10.1093/infdis/jiac006

TY - JOUR

T1 - Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept: Proof of Concept

AU - Vedhara, Kavita

AU - Ayling, Kieran

AU - Jia, Ru

AU - Fairclough, Lucy

AU - Morling, Joanne R.

AU - Ball, Jonathan

AU - Knight, Holly

AU - Blake, Holly

AU - Corner, Jessica

AU - Denning, Chris

AU - Bolton, Kirsty

AU - Jackson, Hannah

AU - Coupland, Carol

AU - Tighe, Patrick

PY - 2022/6/15

Y1 - 2022/6/15

N2 - Background: Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Participants (n=102) completed measures of anxiety, depression, positive mood, and loneliness and provided a blood sample for the measurement of antibodies to the SARS-CoV-2 spike and nucleocapsid proteins. Results: SARS-CoV-2 was significantly negatively associated with anxiety and depression. The model remained significant after adjustment for age and gender, although anxiety and depression were no longer significant independent predictors. Conclusions: These findings offer early support for the hypothesis that psychological factors may influence susceptibility to SARS-CoV-2 infection.

AB - Background: Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Participants (n=102) completed measures of anxiety, depression, positive mood, and loneliness and provided a blood sample for the measurement of antibodies to the SARS-CoV-2 spike and nucleocapsid proteins. Results: SARS-CoV-2 was significantly negatively associated with anxiety and depression. The model remained significant after adjustment for age and gender, although anxiety and depression were no longer significant independent predictors. Conclusions: These findings offer early support for the hypothesis that psychological factors may influence susceptibility to SARS-CoV-2 infection.

KW - antibodies

KW - anxiety

KW - COVID-19

KW - depression

KW - SARS-CoV-2

U2 - 10.1093/infdis/jiac006

DO - 10.1093/infdis/jiac006

M3 - Article

VL - 225

SP - 2137

EP - 2141

JO - Journal of Infectious Disease

JF - Journal of Infectious Disease

IS - 12

ER -

Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept: Proof of Concept

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Keywords

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