Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

Jason Biswas; A. Patel; J. A. Otter; P. Wade; W. Newsholme; E. van Kleef; S. D. Goldenberg

doi:10.1016/j.jhin.2015.01.015

Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

Jason Biswas
, A. Patel
, J. A. Otter
, P. Wade
, W. Newsholme
, E. van Kleef
, S. D. Goldenberg

Guy's and St Thomas' NHS Foundation Trust
London School of Hygiene and Tropical Medicine
UK Health Security Agency

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C.difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) ( P=0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C.difficile.

Original language	English
Pages (from-to)	267-270
Number of pages	4
Journal	Journal of Hospital Infection
Volume	90
Issue number	3
DOIs	https://doi.org/10.1016/j.jhin.2015.01.015
Publication status	Published - 1 Jul 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Clostridium difficile
Contamination
Environment
Fidaxomicin

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10.1016/j.jhin.2015.01.015Licence: CC BY-NC-ND

Cite this

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title = "Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin",

abstract = "Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C.difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8\%) than patients treated with metronidazole and/or vancomycin (38/66 57.6\%) ( P=0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C.difficile.",

keywords = "Clostridium difficile, Contamination, Environment, Fidaxomicin",

author = "Jason Biswas and A. Patel and Otter, \{J. A.\} and P. Wade and W. Newsholme and \{van Kleef\}, E. and Goldenberg, \{S. D.\}",

year = "2015",

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doi = "10.1016/j.jhin.2015.01.015",

language = "English",

volume = "90",

pages = "267--270",

journal = "Journal of Hospital Infection",

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}

TY - JOUR

T1 - Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

AU - Biswas, Jason

AU - Patel, A.

AU - Otter, J. A.

AU - Wade, P.

AU - Newsholme, W.

AU - van Kleef, E.

AU - Goldenberg, S. D.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C.difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) ( P=0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C.difficile.

AB - Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C.difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) ( P=0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C.difficile.

KW - Clostridium difficile

KW - Contamination

KW - Environment

KW - Fidaxomicin

U2 - 10.1016/j.jhin.2015.01.015

DO - 10.1016/j.jhin.2015.01.015

M3 - Article

SN - 0195-6701

VL - 90

SP - 267

EP - 270

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

IS - 3

ER -

Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin

Abstract

UN SDGs

Keywords

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