Recent highlights in antimalarial drug resistance and chemotherapy research

David A. Fidock; Richard T. Eastman; Steve Ward; Steven R. Meshnick

doi:10.1016/j.pt.2008.09.005

Recent highlights in antimalarial drug resistance and chemotherapy research

David A. Fidock
, Richard T. Eastman
, Steve Ward
, Steven R. Meshnick

Tropical Disease Biology

Columbia University
University of North Carolina at Chapel Hill

Research output: Contribution to journal › Review article › peer-review

101 Citations (Scopus)

Abstract

This review summarizes recent investigations into antimalarial drug resistance and chemotherapy, including reports of some of the many exciting talks and posters on this topic that were presented at the third Molecular Approaches to Malaria meeting held in Lorne, Australia, in February 2008 (MAM 2008). After surveying this area of research, we focus on two important questions: what is the molecular contribution of pfcrt to chloroquine resistance, and what is the mechanism of action of artemisinin? We conclude with thoughts about the current state of antimalarial chemotherapy and priorities moving forward.

Original language	English
Pages (from-to)	537-544
Number of pages	8
Journal	Trends In Parasitology
Volume	24
Issue number	12
DOIs	https://doi.org/10.1016/j.pt.2008.09.005
Publication status	Published - 1 Dec 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.pt.2008.09.005

Cite this

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abstract = "This review summarizes recent investigations into antimalarial drug resistance and chemotherapy, including reports of some of the many exciting talks and posters on this topic that were presented at the third Molecular Approaches to Malaria meeting held in Lorne, Australia, in February 2008 (MAM 2008). After surveying this area of research, we focus on two important questions: what is the molecular contribution of pfcrt to chloroquine resistance, and what is the mechanism of action of artemisinin? We conclude with thoughts about the current state of antimalarial chemotherapy and priorities moving forward.",

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AU - Meshnick, Steven R.

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DO - 10.1016/j.pt.2008.09.005

M3 - Review article

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Recent highlights in antimalarial drug resistance and chemotherapy research

Abstract

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