Rapid increase in Omicron infections in England during December 2021: REACT-1 study: REACT-1 study

Paul Elliott; Barbara Bodinier; Oliver Eales; Haowei Wang; David Haw; Joshua Elliott; Matthew Whitaker; Jakob Jonnerby; David Tang; Caroline E. Walters; Christina Atchison; Peter Diggle; Andrew J. Page; Alexander J. Trotter; Deborah Ashby; Wendy Barclay; Graham Taylor; Helen Ward; Ara Darzi; Graham S. Cooke; Marc Chadeau-Hyam; Christl A. Donnelly

doi:10.1126/science.abn8347

Rapid increase in Omicron infections in England during December 2021: REACT-1 study: REACT-1 study

Paul Elliott, Barbara Bodinier, Oliver Eales, Haowei Wang, David Haw, Joshua Elliott, Matthew Whitaker, Jakob Jonnerby, David Tang, Caroline E. Walters, Christina Atchison, Peter Diggle, Andrew J. Page, Alexander J. Trotter, Deborah Ashby, Wendy Barclay, Graham Taylor, Helen Ward, Ara Darzi, Graham S. CookeMarc Chadeau-Hyam, Christl A. Donnelly

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

The unprecedented rise in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed the prevalence of SARS-CoV-2 and its dynamics in England from the end of November to mid-December 2021 among almost 100,000 participants in the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, with an increasing proportion of infections due to Omicron. We observed large decreases in swab positivity among mostly vaccinated older children (12 to 17 years) relative to unvaccinated younger children (5 to 11 years), and in adults who received a third (booster) vaccine dose versus two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.

Original language	English
Pages (from-to)	1406-1411
Number of pages	6
Journal	Science
Volume	375
Issue number	6587
DOIs	https://doi.org/10.1126/science.abn8347
Publication status	Published - 25 Mar 2022
Externally published	Yes

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Elliott, P., Bodinier, B., Eales, O., Wang, H., Haw, D., Elliott, J., Whitaker, M., Jonnerby, J., Tang, D., Walters, C. E., Atchison, C., Diggle, P., Page, A. J., Trotter, A. J., Ashby, D., Barclay, W., Taylor, G., Ward, H., Darzi, A., ... Donnelly, C. A. (2022). Rapid increase in Omicron infections in England during December 2021: REACT-1 study: REACT-1 study. Science, 375(6587), 1406-1411. https://doi.org/10.1126/science.abn8347

@article{4b95fd655a954857bc66866d366aa430,

title = "Rapid increase in Omicron infections in England during December 2021: REACT-1 study: REACT-1 study",

abstract = "The unprecedented rise in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed the prevalence of SARS-CoV-2 and its dynamics in England from the end of November to mid-December 2021 among almost 100,000 participants in the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, with an increasing proportion of infections due to Omicron. We observed large decreases in swab positivity among mostly vaccinated older children (12 to 17 years) relative to unvaccinated younger children (5 to 11 years), and in adults who received a third (booster) vaccine dose versus two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.",

author = "Paul Elliott and Barbara Bodinier and Oliver Eales and Haowei Wang and David Haw and Joshua Elliott and Matthew Whitaker and Jakob Jonnerby and David Tang and Walters, \{Caroline E.\} and Christina Atchison and Peter Diggle and Page, \{Andrew J.\} and Trotter, \{Alexander J.\} and Deborah Ashby and Wendy Barclay and Graham Taylor and Helen Ward and Ara Darzi and Cooke, \{Graham S.\} and Marc Chadeau-Hyam and Donnelly, \{Christl A.\}",

year = "2022",

month = mar,

day = "25",

doi = "10.1126/science.abn8347",

language = "English",

volume = "375",

pages = "1406--1411",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6587",

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Elliott, P, Bodinier, B, Eales, O, Wang, H, Haw, D, Elliott, J, Whitaker, M, Jonnerby, J, Tang, D, Walters, CE, Atchison, C, Diggle, P, Page, AJ, Trotter, AJ, Ashby, D, Barclay, W, Taylor, G, Ward, H, Darzi, A, Cooke, GS, Chadeau-Hyam, M & Donnelly, CA 2022, 'Rapid increase in Omicron infections in England during December 2021: REACT-1 study: REACT-1 study', Science, vol. 375, no. 6587, pp. 1406-1411. https://doi.org/10.1126/science.abn8347

TY - JOUR

T1 - Rapid increase in Omicron infections in England during December 2021: REACT-1 study: REACT-1 study

AU - Elliott, Paul

AU - Bodinier, Barbara

AU - Eales, Oliver

AU - Wang, Haowei

AU - Haw, David

AU - Elliott, Joshua

AU - Whitaker, Matthew

AU - Jonnerby, Jakob

AU - Tang, David

AU - Walters, Caroline E.

AU - Atchison, Christina

AU - Diggle, Peter

AU - Page, Andrew J.

AU - Trotter, Alexander J.

AU - Ashby, Deborah

AU - Barclay, Wendy

AU - Taylor, Graham

AU - Ward, Helen

AU - Darzi, Ara

AU - Cooke, Graham S.

AU - Chadeau-Hyam, Marc

AU - Donnelly, Christl A.

PY - 2022/3/25

Y1 - 2022/3/25

N2 - The unprecedented rise in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed the prevalence of SARS-CoV-2 and its dynamics in England from the end of November to mid-December 2021 among almost 100,000 participants in the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, with an increasing proportion of infections due to Omicron. We observed large decreases in swab positivity among mostly vaccinated older children (12 to 17 years) relative to unvaccinated younger children (5 to 11 years), and in adults who received a third (booster) vaccine dose versus two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.

AB - The unprecedented rise in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed the prevalence of SARS-CoV-2 and its dynamics in England from the end of November to mid-December 2021 among almost 100,000 participants in the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, with an increasing proportion of infections due to Omicron. We observed large decreases in swab positivity among mostly vaccinated older children (12 to 17 years) relative to unvaccinated younger children (5 to 11 years), and in adults who received a third (booster) vaccine dose versus two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.

U2 - 10.1126/science.abn8347

DO - 10.1126/science.abn8347

M3 - Article

SN - 0036-8075

VL - 375

SP - 1406

EP - 1411

JO - Science

JF - Science

IS - 6587

ER -

Rapid increase in Omicron infections in England during December 2021: REACT-1 study: REACT-1 study

Abstract

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