Quality of life and related factors among chronic hepatitis B-infected patients: A multi-center study, Turkey: A multi-center study, Turkey

Zehra Karacaer; Banu Cakir; Hakan Erdem; Kenan Ugurlu; Gul Durmus; Nevin Koc Ince; Cinar Ozturk; Rodrigo Hasbun; Ayse Batirel; Esmeray Mutlu Yilmaz; Ilkay Bozkurt; Mustafa Sunbul; Aynur Aynioglu; Aynur Atilla; Ayse Erbay; Ayse Inci; Cigdem Kader; Elif Tukenmez Tigen; Gokhan Karaahmetoglu; Seher Ayten Coskuner; Ebru Dik; Huseyin Tarakci; Selma Tosun; Fatime Korkmaz; Servet Kolgelier; Fatma Yilmaz Karadag; Serpil Erol; Kamuran Turker; Ceyda Necan; Ahmet Melih Sahin; Pinar Ergen; Gulsen Iskender; Pinar Korkmaz; Esma Gulesen Eroglu; Yasemin Durdu; Mehmet Ulug; Suna Secil Deniz; Filiz Koc; Saygin Nayman Alpat; Nefise Oztoprak; Omer Evirgen; Hamdi Sozen; Mustafa Dogan; Selcuk Kaya; Safak Kaya; Mustafa Altindis; Emel Aslan; Recep Tekin; Busra Ergut Sezer; Kevser Ozdemir; Gulden Ersoz; Ahmet Sahin; Ilhami Celik; Emsal Aydin; Aliye Bastug; Rezan Harman; Hacer Deniz Ozkaya; Emine Parlak; Ilknur Yavuz; Suzan Sacar; Senol Comoglu; Ercan Yenilmez; Fatma Sirmatel; Ilker Inanc Balkan; Yesim Alpay; Mustafa Hatipoglu; Affan Denk; Gunes Senol; Mehmet Bitirgen; Mehmet Faruk Geyik; Rahmet Guner; Ayten Kadanali; Ahmet Karakas; Mustafa Namiduru; Hatice Udurgucu; Rukiye Pinar Boluktas; Ergenekon Karagoz; Necati Ormeci

doi:10.1186/s12955-016-0557-9

Quality of life and related factors among chronic hepatitis B-infected patients: A multi-center study, Turkey: A multi-center study, Turkey

Zehra Karacaer, Banu Cakir, Hakan Erdem, Kenan Ugurlu, Gul Durmus, Nevin Koc Ince, Cinar Ozturk, Rodrigo Hasbun, Ayse Batirel, Esmeray Mutlu Yilmaz, Ilkay Bozkurt, Mustafa Sunbul, Aynur Aynioglu, Aynur Atilla, Ayse Erbay, Ayse Inci, Cigdem Kader, Elif Tukenmez Tigen, Gokhan Karaahmetoglu, Seher Ayten CoskunerEbru Dik, Huseyin Tarakci, Selma Tosun, Fatime Korkmaz, Servet Kolgelier, Fatma Yilmaz Karadag, Serpil Erol, Kamuran Turker, Ceyda Necan, Ahmet Melih Sahin, Pinar Ergen, Gulsen Iskender, Pinar Korkmaz, Esma Gulesen Eroglu, Yasemin Durdu, Mehmet Ulug, Suna Secil Deniz, Filiz Koc, Saygin Nayman Alpat, Nefise Oztoprak, Omer Evirgen, Hamdi Sozen, Mustafa Dogan, Selcuk Kaya, Safak Kaya, Mustafa Altindis, Emel Aslan, Recep Tekin, Busra Ergut Sezer, Kevser Ozdemir, Gulden Ersoz, Ahmet Sahin, Ilhami Celik, Emsal Aydin, Aliye Bastug, Rezan Harman, Hacer Deniz Ozkaya, Emine Parlak, Ilknur Yavuz, Suzan Sacar, Senol Comoglu, Ercan Yenilmez, Fatma Sirmatel, Ilker Inanc Balkan, Yesim Alpay, Mustafa Hatipoglu, Affan Denk, Gunes Senol, Mehmet Bitirgen, Mehmet Faruk Geyik, Rahmet Guner, Ayten Kadanali, Ahmet Karakas, Mustafa Namiduru, Hatice Udurgucu, Rukiye Pinar Boluktas, Ergenekon Karagoz, Necati Ormeci

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors. Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant. Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided. Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.

Original language	English
Article number	153
Journal	Health and Quality of Life Outcomes
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s12955-016-0557-9
Publication status	Published - 3 Nov 2016
Externally published	Yes

Keywords

Chronic hepatitis B infection
Quality of life
The Hepatitis B Quality of Life Instrument
Turkey

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12955-016-0557-9

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Karacaer, Z., Cakir, B., Erdem, H., Ugurlu, K., Durmus, G., Ince, N. K., Ozturk, C., Hasbun, R., Batirel, A., Yilmaz, E. M., Bozkurt, I., Sunbul, M., Aynioglu, A., Atilla, A., Erbay, A., Inci, A., Kader, C., Tigen, E. T., Karaahmetoglu, G., ... Ormeci, N. (2016). Quality of life and related factors among chronic hepatitis B-infected patients: A multi-center study, Turkey: A multi-center study, Turkey. Health and Quality of Life Outcomes, 14(1), Article 153. https://doi.org/10.1186/s12955-016-0557-9

@article{26d05e53461e45df81c6904dec937e69,

title = "Quality of life and related factors among chronic hepatitis B-infected patients: A multi-center study, Turkey: A multi-center study, Turkey",

abstract = "Background: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors. Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant. Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 \%) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 \%), 1721 (40.4 \%) and 1007 (23.7 \%) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided. Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.",

keywords = "Chronic hepatitis B infection, Quality of life, The Hepatitis B Quality of Life Instrument, Turkey",

author = "Zehra Karacaer and Banu Cakir and Hakan Erdem and Kenan Ugurlu and Gul Durmus and Ince, \{Nevin Koc\} and Cinar Ozturk and Rodrigo Hasbun and Ayse Batirel and Yilmaz, \{Esmeray Mutlu\} and Ilkay Bozkurt and Mustafa Sunbul and Aynur Aynioglu and Aynur Atilla and Ayse Erbay and Ayse Inci and Cigdem Kader and Tigen, \{Elif Tukenmez\} and Gokhan Karaahmetoglu and Coskuner, \{Seher Ayten\} and Ebru Dik and Huseyin Tarakci and Selma Tosun and Fatime Korkmaz and Servet Kolgelier and Karadag, \{Fatma Yilmaz\} and Serpil Erol and Kamuran Turker and Ceyda Necan and Sahin, \{Ahmet Melih\} and Pinar Ergen and Gulsen Iskender and Pinar Korkmaz and Eroglu, \{Esma Gulesen\} and Yasemin Durdu and Mehmet Ulug and Deniz, \{Suna Secil\} and Filiz Koc and Alpat, \{Saygin Nayman\} and Nefise Oztoprak and Omer Evirgen and Hamdi Sozen and Mustafa Dogan and Selcuk Kaya and Safak Kaya and Mustafa Altindis and Emel Aslan and Recep Tekin and Sezer, \{Busra Ergut\} and Kevser Ozdemir and Gulden Ersoz and Ahmet Sahin and Ilhami Celik and Emsal Aydin and Aliye Bastug and Rezan Harman and Ozkaya, \{Hacer Deniz\} and Emine Parlak and Ilknur Yavuz and Suzan Sacar and Senol Comoglu and Ercan Yenilmez and Fatma Sirmatel and Balkan, \{Ilker Inanc\} and Yesim Alpay and Mustafa Hatipoglu and Affan Denk and Gunes Senol and Mehmet Bitirgen and Geyik, \{Mehmet Faruk\} and Rahmet Guner and Ayten Kadanali and Ahmet Karakas and Mustafa Namiduru and Hatice Udurgucu and Boluktas, \{Rukiye Pinar\} and Ergenekon Karagoz and Necati Ormeci",

year = "2016",

month = nov,

day = "3",

doi = "10.1186/s12955-016-0557-9",

language = "English",

volume = "14",

journal = "Health and Quality of Life Outcomes",

issn = "1477-7525",

publisher = "BioMed Central Ltd",

number = "1",

}

Karacaer, Z, Cakir, B, Erdem, H, Ugurlu, K, Durmus, G, Ince, NK, Ozturk, C, Hasbun, R, Batirel, A, Yilmaz, EM, Bozkurt, I, Sunbul, M, Aynioglu, A, Atilla, A, Erbay, A, Inci, A, Kader, C, Tigen, ET, Karaahmetoglu, G, Coskuner, SA, Dik, E, Tarakci, H, Tosun, S, Korkmaz, F, Kolgelier, S, Karadag, FY, Erol, S, Turker, K, Necan, C, Sahin, AM, Ergen, P, Iskender, G, Korkmaz, P, Eroglu, EG, Durdu, Y, Ulug, M, Deniz, SS, Koc, F, Alpat, SN, Oztoprak, N, Evirgen, O, Sozen, H, Dogan, M, Kaya, S, Kaya, S, Altindis, M, Aslan, E, Tekin, R, Sezer, BE, Ozdemir, K, Ersoz, G, Sahin, A, Celik, I, Aydin, E, Bastug, A, Harman, R, Ozkaya, HD, Parlak, E, Yavuz, I, Sacar, S, Comoglu, S, Yenilmez, E, Sirmatel, F, Balkan, II, Alpay, Y, Hatipoglu, M, Denk, A, Senol, G, Bitirgen, M, Geyik, MF, Guner, R, Kadanali, A, Karakas, A, Namiduru, M, Udurgucu, H, Boluktas, RP, Karagoz, E & Ormeci, N 2016, 'Quality of life and related factors among chronic hepatitis B-infected patients: A multi-center study, Turkey: A multi-center study, Turkey', Health and Quality of Life Outcomes, vol. 14, no. 1, 153. https://doi.org/10.1186/s12955-016-0557-9

TY - JOUR

T1 - Quality of life and related factors among chronic hepatitis B-infected patients: A multi-center study, Turkey: A multi-center study, Turkey

AU - Karacaer, Zehra

AU - Cakir, Banu

AU - Erdem, Hakan

AU - Ugurlu, Kenan

AU - Durmus, Gul

AU - Ince, Nevin Koc

AU - Ozturk, Cinar

AU - Hasbun, Rodrigo

AU - Batirel, Ayse

AU - Yilmaz, Esmeray Mutlu

AU - Bozkurt, Ilkay

AU - Sunbul, Mustafa

AU - Aynioglu, Aynur

AU - Atilla, Aynur

AU - Erbay, Ayse

AU - Inci, Ayse

AU - Kader, Cigdem

AU - Tigen, Elif Tukenmez

AU - Karaahmetoglu, Gokhan

AU - Coskuner, Seher Ayten

AU - Dik, Ebru

AU - Tarakci, Huseyin

AU - Tosun, Selma

AU - Korkmaz, Fatime

AU - Kolgelier, Servet

AU - Karadag, Fatma Yilmaz

AU - Erol, Serpil

AU - Turker, Kamuran

AU - Necan, Ceyda

AU - Sahin, Ahmet Melih

AU - Ergen, Pinar

AU - Iskender, Gulsen

AU - Korkmaz, Pinar

AU - Eroglu, Esma Gulesen

AU - Durdu, Yasemin

AU - Ulug, Mehmet

AU - Deniz, Suna Secil

AU - Koc, Filiz

AU - Alpat, Saygin Nayman

AU - Oztoprak, Nefise

AU - Evirgen, Omer

AU - Sozen, Hamdi

AU - Dogan, Mustafa

AU - Kaya, Selcuk

AU - Kaya, Safak

AU - Altindis, Mustafa

AU - Aslan, Emel

AU - Tekin, Recep

AU - Sezer, Busra Ergut

AU - Ozdemir, Kevser

AU - Ersoz, Gulden

AU - Sahin, Ahmet

AU - Celik, Ilhami

AU - Aydin, Emsal

AU - Bastug, Aliye

AU - Harman, Rezan

AU - Ozkaya, Hacer Deniz

AU - Parlak, Emine

AU - Yavuz, Ilknur

AU - Sacar, Suzan

AU - Comoglu, Senol

AU - Yenilmez, Ercan

AU - Sirmatel, Fatma

AU - Balkan, Ilker Inanc

AU - Alpay, Yesim

AU - Hatipoglu, Mustafa

AU - Denk, Affan

AU - Senol, Gunes

AU - Bitirgen, Mehmet

AU - Geyik, Mehmet Faruk

AU - Guner, Rahmet

AU - Kadanali, Ayten

AU - Karakas, Ahmet

AU - Namiduru, Mustafa

AU - Udurgucu, Hatice

AU - Boluktas, Rukiye Pinar

AU - Karagoz, Ergenekon

AU - Ormeci, Necati

PY - 2016/11/3

Y1 - 2016/11/3

N2 - Background: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors. Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant. Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided. Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.

AB - Background: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors. Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant. Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided. Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.

KW - Chronic hepatitis B infection

KW - Quality of life

KW - The Hepatitis B Quality of Life Instrument

KW - Turkey

U2 - 10.1186/s12955-016-0557-9

DO - 10.1186/s12955-016-0557-9

M3 - Article

SN - 1477-7525

VL - 14

JO - Health and Quality of Life Outcomes

JF - Health and Quality of Life Outcomes

IS - 1

M1 - 153

ER -

Quality of life and related factors among chronic hepatitis B-infected patients: A multi-center study, Turkey: A multi-center study, Turkey

Abstract

Keywords

UN SDGs

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