Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar

Caitlin Sheehy; Heather Lawson; Emmanuel H. Andriamasy; Hannah J. Russell; Alice Reid; Gina U. Raderalazasoa; Graham Dodge; Robbie Kornitschky; James M.St J. Penney; Tahiry N. Ranaivoson; Antsa Andrianiaina; Jenny S. Emmanoela; Amaya L. Bustinduy; Russell Stothard; Louis Andrianjaka; Stephen Spencer

doi:10.1186/s40249-021-00871-y

Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar

Caitlin Sheehy
, Heather Lawson
, Emmanuel H. Andriamasy
, Hannah J. Russell
, Alice Reid
, Gina U. Raderalazasoa
, Graham Dodge
, Robbie Kornitschky
, James M.St J. Penney
, Tahiry N. Ranaivoson
, Antsa Andrianiaina
, Jenny S. Emmanoela
, Amaya L. Bustinduy
, Russell Stothard
, Louis Andrianjaka
, Stephen Spencer

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

School-aged children (SAC) have a considerable burden of intestinal schistosomiasis in Madagascar yet its burden

in pre-school aged children (PSAC) is currently overlooked. To assess the at-risk status of PSAC, we undertook a pilot

epidemiological survey in June 2019 examining children (n = 89), aged 2–4-years of balanced gender, in six remote

villages in Marolambo District, Madagascar. Diagnosis included use of urine-circulating cathodic antigen (CCA) dipsticks

and coproscopy of stool with duplicate Kato-Katz (K-K) thick smears. Prevalence of intestinal schistosomiasis by

urine-CCA was 67.4% (95% confidence interval [CI]: 56.5–77.2%) and 35.0% (95% CI: 24.7–46.5%) by K-K. The relationship

between faecal eggs per gram (epg) and urine-CCA G-scores (G1 to G10) was assessed by linear regression modelling,

finding for every increment in G-score, epg increased by 20.4 (6.50–34.4, P = 0.006). Observed proportions of

faecal epg intensities were light (78.6%), moderate (17.9%) and heavy (3.6%). Soil-transmitted helminthiasis was noted,

prevalence of ascariasis was 18.8% and trichuriasis was 33.8% (hookworm was not reported). Co-infection of intestinal

schistosomiasis and soil-transmitted helminthiasis occurred in 36.3% of PSAC. These results provide solid evidence

highlighting the overlooked burden of intestinal schistosomiasis in PSAC, and they also offer technical guidance for

better surveillance data for the Madagascan national control programme.

Original language	English
Article number	87
Journal	Infectious Diseases of Poverty
Volume	10
Issue number	1
Early online date	25 Jun 2021
DOIs	https://doi.org/10.1186/s40249-021-00871-y
Publication status	E-pub ahead of print - 25 Jun 2021

Keywords

Mass drug administration
Paediatric
Praziquantel
Schistosoma mansoni
Soil-transmitted helminthiasis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s40249-021-00871-yLicence: CC BY

Schisto MadagascarFinal published version, 1.25 MBLicence: CC BY

Cite this

Sheehy, C., Lawson, H., Andriamasy, E. H., Russell, H. J., Reid, A., Raderalazasoa, G. U., Dodge, G., Kornitschky, R., Penney, J. M. S. J., Ranaivoson, T. N., Andrianiaina, A., Emmanoela, J. S., Bustinduy, A. L., Stothard, R., Andrianjaka, L., & Spencer, S. (2021). Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar. Infectious Diseases of Poverty, 10(1), Article 87. Advance online publication. https://doi.org/10.1186/s40249-021-00871-y

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title = "Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar",

abstract = "School-aged children (SAC) have a considerable burden of intestinal schistosomiasis in Madagascar yet its burdenin pre-school aged children (PSAC) is currently overlooked. To assess the at-risk status of PSAC, we undertook a pilotepidemiological survey in June 2019 examining children (n = 89), aged 2–4-years of balanced gender, in six remotevillages in Marolambo District, Madagascar. Diagnosis included use of urine-circulating cathodic antigen (CCA) dipsticksand coproscopy of stool with duplicate Kato-Katz (K-K) thick smears. Prevalence of intestinal schistosomiasis byurine-CCA was 67.4\% (95\% confidence interval [CI]: 56.5–77.2\%) and 35.0\% (95\% CI: 24.7–46.5\%) by K-K. The relationshipbetween faecal eggs per gram (epg) and urine-CCA G-scores (G1 to G10) was assessed by linear regression modelling,finding for every increment in G-score, epg increased by 20.4 (6.50–34.4, P = 0.006). Observed proportions offaecal epg intensities were light (78.6\%), moderate (17.9\%) and heavy (3.6\%). Soil-transmitted helminthiasis was noted,prevalence of ascariasis was 18.8\% and trichuriasis was 33.8\% (hookworm was not reported). Co-infection of intestinalschistosomiasis and soil-transmitted helminthiasis occurred in 36.3\% of PSAC. These results provide solid evidencehighlighting the overlooked burden of intestinal schistosomiasis in PSAC, and they also offer technical guidance forbetter surveillance data for the Madagascan national control programme.",

keywords = "Mass drug administration, Paediatric, Praziquantel, Schistosoma mansoni, Soil-transmitted helminthiasis",

author = "Caitlin Sheehy and Heather Lawson and Andriamasy, \{Emmanuel H.\} and Russell, \{Hannah J.\} and Alice Reid and Raderalazasoa, \{Gina U.\} and Graham Dodge and Robbie Kornitschky and Penney, \{James M.St J.\} and Ranaivoson, \{Tahiry N.\} and Antsa Andrianiaina and Emmanoela, \{Jenny S.\} and Bustinduy, \{Amaya L.\} and Russell Stothard and Louis Andrianjaka and Stephen Spencer",

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doi = "10.1186/s40249-021-00871-y",

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Sheehy, C, Lawson, H, Andriamasy, EH, Russell, HJ, Reid, A, Raderalazasoa, GU, Dodge, G, Kornitschky, R, Penney, JMSJ, Ranaivoson, TN, Andrianiaina, A, Emmanoela, JS, Bustinduy, AL, Stothard, R, Andrianjaka, L & Spencer, S 2021, 'Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar', Infectious Diseases of Poverty, vol. 10, no. 1, 87. https://doi.org/10.1186/s40249-021-00871-y

TY - JOUR

T1 - Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar

AU - Sheehy, Caitlin

AU - Lawson, Heather

AU - Andriamasy, Emmanuel H.

AU - Russell, Hannah J.

AU - Reid, Alice

AU - Raderalazasoa, Gina U.

AU - Dodge, Graham

AU - Kornitschky, Robbie

AU - Penney, James M.St J.

AU - Ranaivoson, Tahiry N.

AU - Andrianiaina, Antsa

AU - Emmanoela, Jenny S.

AU - Bustinduy, Amaya L.

AU - Stothard, Russell

AU - Andrianjaka, Louis

AU - Spencer, Stephen

PY - 2021/6/25

Y1 - 2021/6/25

N2 - School-aged children (SAC) have a considerable burden of intestinal schistosomiasis in Madagascar yet its burdenin pre-school aged children (PSAC) is currently overlooked. To assess the at-risk status of PSAC, we undertook a pilotepidemiological survey in June 2019 examining children (n = 89), aged 2–4-years of balanced gender, in six remotevillages in Marolambo District, Madagascar. Diagnosis included use of urine-circulating cathodic antigen (CCA) dipsticksand coproscopy of stool with duplicate Kato-Katz (K-K) thick smears. Prevalence of intestinal schistosomiasis byurine-CCA was 67.4% (95% confidence interval [CI]: 56.5–77.2%) and 35.0% (95% CI: 24.7–46.5%) by K-K. The relationshipbetween faecal eggs per gram (epg) and urine-CCA G-scores (G1 to G10) was assessed by linear regression modelling,finding for every increment in G-score, epg increased by 20.4 (6.50–34.4, P = 0.006). Observed proportions offaecal epg intensities were light (78.6%), moderate (17.9%) and heavy (3.6%). Soil-transmitted helminthiasis was noted,prevalence of ascariasis was 18.8% and trichuriasis was 33.8% (hookworm was not reported). Co-infection of intestinalschistosomiasis and soil-transmitted helminthiasis occurred in 36.3% of PSAC. These results provide solid evidencehighlighting the overlooked burden of intestinal schistosomiasis in PSAC, and they also offer technical guidance forbetter surveillance data for the Madagascan national control programme.

AB - School-aged children (SAC) have a considerable burden of intestinal schistosomiasis in Madagascar yet its burdenin pre-school aged children (PSAC) is currently overlooked. To assess the at-risk status of PSAC, we undertook a pilotepidemiological survey in June 2019 examining children (n = 89), aged 2–4-years of balanced gender, in six remotevillages in Marolambo District, Madagascar. Diagnosis included use of urine-circulating cathodic antigen (CCA) dipsticksand coproscopy of stool with duplicate Kato-Katz (K-K) thick smears. Prevalence of intestinal schistosomiasis byurine-CCA was 67.4% (95% confidence interval [CI]: 56.5–77.2%) and 35.0% (95% CI: 24.7–46.5%) by K-K. The relationshipbetween faecal eggs per gram (epg) and urine-CCA G-scores (G1 to G10) was assessed by linear regression modelling,finding for every increment in G-score, epg increased by 20.4 (6.50–34.4, P = 0.006). Observed proportions offaecal epg intensities were light (78.6%), moderate (17.9%) and heavy (3.6%). Soil-transmitted helminthiasis was noted,prevalence of ascariasis was 18.8% and trichuriasis was 33.8% (hookworm was not reported). Co-infection of intestinalschistosomiasis and soil-transmitted helminthiasis occurred in 36.3% of PSAC. These results provide solid evidencehighlighting the overlooked burden of intestinal schistosomiasis in PSAC, and they also offer technical guidance forbetter surveillance data for the Madagascan national control programme.

KW - Mass drug administration

KW - Paediatric

KW - Praziquantel

KW - Schistosoma mansoni

KW - Soil-transmitted helminthiasis

U2 - 10.1186/s40249-021-00871-y

DO - 10.1186/s40249-021-00871-y

M3 - Article

SN - 2095-5162

VL - 10

JO - Infectious Diseases of Poverty

JF - Infectious Diseases of Poverty

IS - 1

M1 - 87

ER -

Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar

Abstract

Keywords

UN SDGs

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