Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

Gavin Laing; A. Yarleque; A. Marcelo; E. Rodriguez; David A. Warrell; R.David G. Theakston

doi:10.1016/j.toxicon.2004.03.020

Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

Gavin Laing, A. Yarleque, A. Marcelo, E. Rodriguez, David A. Warrell, R.David G. Theakston

Tropical Disease Biology

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru. (C) 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Toxicon
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/j.toxicon.2004.03.020
Publication status	Published - 1 Jul 2004

Keywords

In vitro tests
In vivo tests
Peru
South American antivenoms
World Health Organization

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abstract = "World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru. (C) 2004 Elsevier Ltd. All rights reserved.",

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T1 - Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

AU - Laing, Gavin

AU - Yarleque, A.

AU - Marcelo, A.

AU - Rodriguez, E.

AU - Warrell, David A.

AU - Theakston, R.David G.

PY - 2004/7/1

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N2 - World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru. (C) 2004 Elsevier Ltd. All rights reserved.

AB - World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru. (C) 2004 Elsevier Ltd. All rights reserved.

KW - In vitro tests

KW - In vivo tests

KW - Peru

KW - South American antivenoms

KW - World Health Organization

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DO - 10.1016/j.toxicon.2004.03.020

M3 - Article

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VL - 44

SP - 103

EP - 106

JO - Toxicon

JF - Toxicon

IS - 1

ER -

Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

Abstract

Keywords

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