Post-acute COVID-19 associated with evidence of bystander t-cell activation and a recurring antibiotic-resistant bacterial pneumonia

Michaela Gregorova; Daniel Morse; Tarcisio Brignoli; Joseph Steventon; Fergus Hamilton; Mahableshwar Albur; David Arnold; Matthew Thomas; Alice Halliday; Holly Baum; Christopher Rice; Matthew B. Avison; Andrew D. Davidson; Marianna Santopaolo; Elizabeth Oliver; Anu Goenka; Adam Finn; Linda Wooldridge; Borko Amulic; Rosemary J. Boyton; Daniel M. Altmann; David K. Butler; Claire McMurray; Joanna Stockton; Sam Nicholls; Charles Cooper; Nicholas Loman; Michael J. Cox; Laura Rivino; Ruth C. Massey

doi:10.7554/eLife.63430

Post-acute COVID-19 associated with evidence of bystander t-cell activation and a recurring antibiotic-resistant bacterial pneumonia

Michaela Gregorova
, Daniel Morse
, Tarcisio Brignoli
, Joseph Steventon
, Fergus Hamilton
, Mahableshwar Albur
, David Arnold
, Matthew Thomas
, Alice Halliday
, Holly Baum
, Christopher Rice
, Matthew B. Avison
, Andrew D. Davidson
, Marianna Santopaolo
, Elizabeth Oliver
, Anu Goenka
, Adam Finn
, Linda Wooldridge
, Borko Amulic
, Rosemary J. Boyton

Daniel M. Altmann, David K. Butler, Claire McMurray, Joanna Stockton, Sam Nicholls, Charles Cooper, Nicholas Loman, Michael J. Cox, Laura Rivino, Ruth C. Massey

University of Bristol
North Bristol NHS Trust
Imperial College London
Royal Brompton and Harefield NHS Foundation Trust
University of Birmingham

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Here, we describe the case of a COVID-19 patient who developed recurring ventilator- associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes.

Original language	English
Article number	e63430
Pages (from-to)	1-13
Number of pages	13
Journal	eLife
Volume	9
DOIs	https://doi.org/10.7554/eLife.63430
Publication status	Published - 31 Dec 2020
Externally published	Yes

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10.7554/eLife.63430Licence: CC BY

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Gregorova, M., Morse, D., Brignoli, T., Steventon, J., Hamilton, F., Albur, M., Arnold, D., Thomas, M., Halliday, A., Baum, H., Rice, C., Avison, M. B., Davidson, A. D., Santopaolo, M., Oliver, E., Goenka, A., Finn, A., Wooldridge, L., Amulic, B., ... Massey, R. C. (2020). Post-acute COVID-19 associated with evidence of bystander t-cell activation and a recurring antibiotic-resistant bacterial pneumonia. eLife, 9, 1-13. Article e63430. https://doi.org/10.7554/eLife.63430

@article{0acbee9ab83048ec93fe690055946347,

title = "Post-acute COVID-19 associated with evidence of bystander t-cell activation and a recurring antibiotic-resistant bacterial pneumonia",

abstract = "Here, we describe the case of a COVID-19 patient who developed recurring ventilator- associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient{\textquoteright}s persistent symptoms and radiological changes.",

author = "Michaela Gregorova and Daniel Morse and Tarcisio Brignoli and Joseph Steventon and Fergus Hamilton and Mahableshwar Albur and David Arnold and Matthew Thomas and Alice Halliday and Holly Baum and Christopher Rice and Avison, \{Matthew B.\} and Davidson, \{Andrew D.\} and Marianna Santopaolo and Elizabeth Oliver and Anu Goenka and Adam Finn and Linda Wooldridge and Borko Amulic and Boyton, \{Rosemary J.\} and Altmann, \{Daniel M.\} and Butler, \{David K.\} and Claire McMurray and Joanna Stockton and Sam Nicholls and Charles Cooper and Nicholas Loman and Cox, \{Michael J.\} and Laura Rivino and Massey, \{Ruth C.\}",

note = "Publisher Copyright: {\textcopyright} Gregorova et al.",

year = "2020",

month = dec,

day = "31",

doi = "10.7554/eLife.63430",

language = "English",

volume = "9",

pages = "1--13",

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Gregorova, M, Morse, D, Brignoli, T, Steventon, J, Hamilton, F, Albur, M, Arnold, D, Thomas, M, Halliday, A, Baum, H, Rice, C, Avison, MB, Davidson, AD, Santopaolo, M, Oliver, E, Goenka, A, Finn, A, Wooldridge, L, Amulic, B, Boyton, RJ, Altmann, DM, Butler, DK, McMurray, C, Stockton, J, Nicholls, S, Cooper, C, Loman, N, Cox, MJ, Rivino, L & Massey, RC 2020, 'Post-acute COVID-19 associated with evidence of bystander t-cell activation and a recurring antibiotic-resistant bacterial pneumonia', eLife, vol. 9, e63430, pp. 1-13. https://doi.org/10.7554/eLife.63430

TY - JOUR

T1 - Post-acute COVID-19 associated with evidence of bystander t-cell activation and a recurring antibiotic-resistant bacterial pneumonia

AU - Gregorova, Michaela

AU - Morse, Daniel

AU - Brignoli, Tarcisio

AU - Steventon, Joseph

AU - Hamilton, Fergus

AU - Albur, Mahableshwar

AU - Arnold, David

AU - Thomas, Matthew

AU - Halliday, Alice

AU - Baum, Holly

AU - Rice, Christopher

AU - Avison, Matthew B.

AU - Davidson, Andrew D.

AU - Santopaolo, Marianna

AU - Oliver, Elizabeth

AU - Goenka, Anu

AU - Finn, Adam

AU - Wooldridge, Linda

AU - Amulic, Borko

AU - Boyton, Rosemary J.

AU - Altmann, Daniel M.

AU - Butler, David K.

AU - McMurray, Claire

AU - Stockton, Joanna

AU - Nicholls, Sam

AU - Cooper, Charles

AU - Loman, Nicholas

AU - Cox, Michael J.

AU - Rivino, Laura

AU - Massey, Ruth C.

PY - 2020/12/31

Y1 - 2020/12/31

N2 - Here, we describe the case of a COVID-19 patient who developed recurring ventilator- associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes.

AB - Here, we describe the case of a COVID-19 patient who developed recurring ventilator- associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes.

U2 - 10.7554/eLife.63430

DO - 10.7554/eLife.63430

M3 - Article

C2 - 33331820

AN - SCOPUS:85099320452

SN - 2050-084X

VL - 9

SP - 1

EP - 13

JO - eLife

JF - eLife

M1 - e63430

ER -

Post-acute COVID-19 associated with evidence of bystander t-cell activation and a recurring antibiotic-resistant bacterial pneumonia

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