TY - JOUR
T1 - Population seroprevalence of SARS-CoV-2 antibodies in Anambra State, South-East, Nigeria
AU - Okpala, Ogo Chukwu Vincent
AU - Dim, Cyril Chukwudi
AU - Ugwu, Chukwuebuka Immanuel
AU - Onyemaechi, Simeon
AU - Uchebo, Obiageli
AU - Chukwulobelu, Ugochukwu
AU - Emembolu, Chuma
AU - Okoye, Ben
AU - Igboekwu, Chukwumuanya
AU - Okoye, Uchenna Benedict
AU - Dike, Nelly Chibuzor
AU - Odumegwu, Anastasia Obiageli
AU - Ideh, Christopher
AU - Okoye, Ngozi Christiana
AU - Okpala, Vincent Chinedu
AU - Okoye, Peter Ikenna
AU - Enike, Maryann Chinyere
AU - Onyedikachi, Oluchi
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/7/19
Y1 - 2021/7/19
N2 - Objective: The objective of this study was to determine the proportion of the Anambra State population that had been infected by the SARS-CoV-2 virus and developed antibodies before the second wave. Methods: The WHO-recommended health facility-based cross-sectional approach was adapted for this survey. Between 8th and 15th December 2020, 3142 participants across the 21 local government areas (LGAs) of the State, aged one year and over, attending randomly selected health facilities, were recruited. Demographic and symptom-related information were collected from the participants as well as whole peripheral blood, which was tested for SARS-CoV-2 IgG and IgM with rapid test kits. Results: 425 participants tested positive for IgG only, 74 for IgM only, while 54 were positive for both IgG and IgM. Overall, 553 positives were recorded, giving a crude seroprevalence of 17.6% (95% CI = 16.26 – 18.98). It ranged widely from 31.9% (95% CI = 24.43 – 40.22) in Onitsha North LGA to 5.4% (95% CI = 2.19 – 10.78) in Awka north. Bayesian Adjustments yielded a state seroprevalence of 16.1%. Conclusion: One in six state residents had been infected by SARS-CoV-2 and developed antibodies before the second wave. All LGAs, age groups, sexes, and settlement types were affected by COVID-19. A large proportion of the population remained susceptible to SARS-CoV-2.
AB - Objective: The objective of this study was to determine the proportion of the Anambra State population that had been infected by the SARS-CoV-2 virus and developed antibodies before the second wave. Methods: The WHO-recommended health facility-based cross-sectional approach was adapted for this survey. Between 8th and 15th December 2020, 3142 participants across the 21 local government areas (LGAs) of the State, aged one year and over, attending randomly selected health facilities, were recruited. Demographic and symptom-related information were collected from the participants as well as whole peripheral blood, which was tested for SARS-CoV-2 IgG and IgM with rapid test kits. Results: 425 participants tested positive for IgG only, 74 for IgM only, while 54 were positive for both IgG and IgM. Overall, 553 positives were recorded, giving a crude seroprevalence of 17.6% (95% CI = 16.26 – 18.98). It ranged widely from 31.9% (95% CI = 24.43 – 40.22) in Onitsha North LGA to 5.4% (95% CI = 2.19 – 10.78) in Awka north. Bayesian Adjustments yielded a state seroprevalence of 16.1%. Conclusion: One in six state residents had been infected by SARS-CoV-2 and developed antibodies before the second wave. All LGAs, age groups, sexes, and settlement types were affected by COVID-19. A large proportion of the population remained susceptible to SARS-CoV-2.
KW - COVID-19 immunity
KW - Disease surveillance
KW - Population survey
KW - SARS-CoV-2 seroepidemiology
U2 - 10.1016/j.ijid.2021.07.040
DO - 10.1016/j.ijid.2021.07.040
M3 - Article
C2 - 34293489
AN - SCOPUS:85112022475
SN - 1201-9712
VL - 110
SP - 171
EP - 178
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
