Population-Level Antibody Estimates to Novel Influenza A/H7N9

M. F. Boni; N. V. V. Chau; N. Dong; Stacy Todd; N. T. D. Nhat; E. de Bruin; J. van Beek; N. T. Hien; C. P. Simmons; J. Farrar; M. Koopmans

doi:10.1093/infdis/jit224

Population-Level Antibody Estimates to Novel Influenza A/H7N9

M. F. Boni, N. V. V. Chau, N. Dong, Stacy Todd, N. T. D. Nhat, E. de Bruin, J. van Beek, N. T. Hien, C. P. Simmons, J. Farrar, M. Koopmans

Clinical Sciences

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

Original language	English
Pages (from-to)	554-558
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	208
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jit224
Publication status	Published - 15 Aug 2013

Keywords

H7N9
Influenza
Microarray
Pandemic
Serology

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10.1093/infdis/jit224Licence: CC BY-NC-ND

J Infect Dis 208 4 554-558Final published version, 824 KBLicence: CC BY-NC-ND

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title = "Population-Level Antibody Estimates to Novel Influenza A/H7N9",

abstract = "There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.",

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AU - Boni, M. F.

AU - Chau, N. V. V.

AU - Dong, N.

AU - Todd, Stacy

AU - Nhat, N. T. D.

AU - de Bruin, E.

AU - van Beek, J.

AU - Hien, N. T.

AU - Simmons, C. P.

AU - Farrar, J.

AU - Koopmans, M.

PY - 2013/8/15

Y1 - 2013/8/15

N2 - There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

AB - There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

KW - H7N9

KW - Influenza

KW - Microarray

KW - Pandemic

KW - Serology

U2 - 10.1093/infdis/jit224

DO - 10.1093/infdis/jit224

M3 - Article

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EP - 558

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 4

ER -

Population-Level Antibody Estimates to Novel Influenza A/H7N9

Abstract

Keywords

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