Population incidence and mortality of sepsis in an urban African setting 2013 - 2016

Background

Sepsis is an important cause of mortality globally, though population incidence estimates from low income settings, including sub-Saharan Africa (sSA), are absent. We aimed to estimate sepsis incidence burden using routinely available data from a large urban hospital in Malawi.

Method

We linked routine-care databases at Queen Elizabeth Central Hospital, Blantyre, Malawi, to provide admission and discharge data for 217,149 adults from 2013-2016. Using a definition of sepsis based on systemic inflammatory response syndrome (SIRS) criteria, and Blantyre census population data, we calculated population incidence estimates of sepsis and severe sepsis and used negative binomial regression to assess for trends over time. Missing data were multiply imputed with chained equations.

Results

We estimate that the incidence rate of emergency department-attending sepsis and severe sepsis in adults was 1772 per 100,000 person-years (95% CI 1754-1789) and 303 per 100,000 person-years (95% CI 295-310) respectively, between 2013 and 2016, with a year-on-year decrease in incidence. In-hospital mortality for patients admitted to the hospital with sepsis and severe sepsis was 23.7% (95% CI 22.7-24.7%) and 28.1% (95% CI 26.1 – 30.0%) respectively, with no clear change over time.

Conclusions

Sepsis incidence is higher in Blantyre, Malawi, than in high-income settings, from where the majority of sepsis incidence data derive. Worldwide sepsis burden is likely to be underestimated, and data from low income countries are needed to inform the public health response.