Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

Hugh Adler; Elissavet Nikolaou; Katherine Gould; Jason Hinds; Andrea Collins; Victoria Connor; Caz Hales; Helen Hill; Angela D. Hyder-Wright; Seher R. Zaidi; Esther German; Jenna F. Gritzfeld; Elena Mitsi; Sherin Pojar; Stephen Gordon; Adam Roberts; Jamie Rylance; Daniela Ferreira

doi:10.1093/infdis/jiz034

Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

Hugh Adler
, Elissavet Nikolaou
, Katherine Gould
, Jason Hinds
, Andrea Collins
, Victoria Connor
, Caz Hales
, Helen Hill
, Angela D. Hyder-Wright
, Seher R. Zaidi
, Esther German
, Jenna F. Gritzfeld
, Elena Mitsi
, Sherin Pojar
, Stephen Gordon
, Adam Roberts
, Jamie Rylance
, Daniela Ferreira

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

Original language	English
Pages (from-to)	1989-1993
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	219
Issue number	12
Early online date	28 Jan 2019
DOIs	https://doi.org/10.1093/infdis/jiz034
Publication status	Published - 15 Jun 2019

Keywords

Drug resistance
Herd immunity
Microbial
Nasal washing
Streptococcus pneumoniae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiz034Licence: CC BY

Pneumococcal colonization JID Revision1 CleanAccepted author manuscript, 79.1 KB

The human lung immune responses to nasopharyngeal pneumococcal colonisation in healthy adults
Mitsi, E. (Author), Ferreira, D. (Supervisor), Jochems, S. (Supervisor) & Jambo, K. (Supervisor), 2019
Student thesis: Doctoral thesis

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Adler, H., Nikolaou, E., Gould, K., Hinds, J., Collins, A., Connor, V., Hales, C., Hill, H., Hyder-Wright, A. D., Zaidi, S. R., German, E., Gritzfeld, J. F., Mitsi, E., Pojar, S., Gordon, S., Roberts, A., Rylance, J., & Ferreira, D. (2019). Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017. Journal of Infectious Diseases, 219(12), 1989-1993. https://doi.org/10.1093/infdis/jiz034

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abstract = "Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5\% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.",

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author = "Hugh Adler and Elissavet Nikolaou and Katherine Gould and Jason Hinds and Andrea Collins and Victoria Connor and Caz Hales and Helen Hill and Hyder-Wright, \{Angela D.\} and Zaidi, \{Seher R.\} and Esther German and Gritzfeld, \{Jenna F.\} and Elena Mitsi and Sherin Pojar and Stephen Gordon and Adam Roberts and Jamie Rylance and Daniela Ferreira",

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Adler, H, Nikolaou, E, Gould, K, Hinds, J, Collins, A, Connor, V, Hales, C, Hill, H, Hyder-Wright, AD, Zaidi, SR, German, E, Gritzfeld, JF, Mitsi, E, Pojar, S, Gordon, S , Roberts, A, Rylance, J & Ferreira, D 2019, 'Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017', Journal of Infectious Diseases, vol. 219, no. 12, pp. 1989-1993. https://doi.org/10.1093/infdis/jiz034

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T1 - Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

AU - Adler, Hugh

AU - Nikolaou, Elissavet

AU - Gould, Katherine

AU - Hinds, Jason

AU - Collins, Andrea

AU - Connor, Victoria

AU - Hales, Caz

AU - Hill, Helen

AU - Hyder-Wright, Angela D.

AU - Zaidi, Seher R.

AU - German, Esther

AU - Gritzfeld, Jenna F.

AU - Mitsi, Elena

AU - Pojar, Sherin

AU - Gordon, Stephen

AU - Roberts, Adam

AU - Rylance, Jamie

AU - Ferreira, Daniela

PY - 2019/6/15

Y1 - 2019/6/15

N2 - Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

AB - Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

KW - Drug resistance

KW - Herd immunity

KW - Microbial

KW - Nasal washing

KW - Streptococcus pneumoniae

U2 - 10.1093/infdis/jiz034

DO - 10.1093/infdis/jiz034

M3 - Article

SN - 0022-1899

VL - 219

SP - 1989

EP - 1993

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 12

ER -

Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

Abstract

Keywords

UN SDGs

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Student theses

The human lung immune responses to nasopharyngeal pneumococcal colonisation in healthy adults

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