Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

Hugh Adler; Elissavet Nikolaou; Katherine Gould; Jason Hinds; Andrea Collins; Victoria Connor; Caz Hales; Helen Hill; Angela D. Hyder-Wright; Seher R. Zaidi; Esther German; Jenna F. Gritzfeld; Elena Mitsi; Sherin Pojar; Stephen Gordon; Adam Roberts; Jamie Rylance; Daniela Ferreira

doi:10.1093/infdis/jiz034

Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

Hugh Adler
, Elissavet Nikolaou
, Katherine Gould
, Jason Hinds
, Andrea Collins
, Victoria Connor
, Caz Hales
, Helen Hill
, Angela D. Hyder-Wright
, Seher R. Zaidi
, Esther German
, Jenna F. Gritzfeld
, Elena Mitsi
, Sherin Pojar
, Stephen Gordon
, Adam Roberts
, Jamie Rylance
, Daniela Ferreira

Liverpool School of Tropical Medicine
Liverpool University Hospitals NHS Foundation Trust
City St George's, University of London
Royal Veterinary College University of London
National Institute for Health and Care Research
Malawi-Liverpool-Wellcome Trust Clinical Research Programme

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

Original language	English
Pages (from-to)	1989-1993
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	219
Issue number	12
Early online date	28 Jan 2019
DOIs	https://doi.org/10.1093/infdis/jiz034
Publication status	Published - 15 Jun 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Drug resistance
Herd immunity
Microbial
Nasal washing
Streptococcus pneumoniae

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10.1093/infdis/jiz034Licence: CC BY

Pneumococcal colonization JID Revision1 CleanAccepted author manuscript, 79.1 KB

The human lung immune responses to nasopharyngeal pneumococcal colonisation in healthy adults
Mitsi, E. (Author), Ferreira, D. (Supervisor), Jochems, S. (Supervisor) & Jambo, K. (Supervisor), 2019
Student thesis: Doctoral thesis

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Adler, H., Nikolaou, E., Gould, K., Hinds, J., Collins, A., Connor, V., Hales, C., Hill, H., Hyder-Wright, A. D., Zaidi, S. R., German, E., Gritzfeld, J. F., Mitsi, E., Pojar, S., Gordon, S., Roberts, A., Rylance, J., & Ferreira, D. (2019). Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017. Journal of Infectious Diseases, 219(12), 1989-1993. https://doi.org/10.1093/infdis/jiz034

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abstract = "Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5\% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.",

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author = "Hugh Adler and Elissavet Nikolaou and Katherine Gould and Jason Hinds and Andrea Collins and Victoria Connor and Caz Hales and Helen Hill and Hyder-Wright, \{Angela D.\} and Zaidi, \{Seher R.\} and Esther German and Gritzfeld, \{Jenna F.\} and Elena Mitsi and Sherin Pojar and Stephen Gordon and Adam Roberts and Jamie Rylance and Daniela Ferreira",

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Adler, H, Nikolaou, E, Gould, K, Hinds, J, Collins, A, Connor, V, Hales, C, Hill, H, Hyder-Wright, AD, Zaidi, SR, German, E, Gritzfeld, JF, Mitsi, E, Pojar, S, Gordon, S , Roberts, A, Rylance, J & Ferreira, D 2019, 'Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017', Journal of Infectious Diseases, vol. 219, no. 12, pp. 1989-1993. https://doi.org/10.1093/infdis/jiz034

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T1 - Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

AU - Adler, Hugh

AU - Nikolaou, Elissavet

AU - Gould, Katherine

AU - Hinds, Jason

AU - Collins, Andrea

AU - Connor, Victoria

AU - Hales, Caz

AU - Hill, Helen

AU - Hyder-Wright, Angela D.

AU - Zaidi, Seher R.

AU - German, Esther

AU - Gritzfeld, Jenna F.

AU - Mitsi, Elena

AU - Pojar, Sherin

AU - Gordon, Stephen

AU - Roberts, Adam

AU - Rylance, Jamie

AU - Ferreira, Daniela

PY - 2019/6/15

Y1 - 2019/6/15

N2 - Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

AB - Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

KW - Drug resistance

KW - Herd immunity

KW - Microbial

KW - Nasal washing

KW - Streptococcus pneumoniae

U2 - 10.1093/infdis/jiz034

DO - 10.1093/infdis/jiz034

M3 - Article

SN - 0022-1899

VL - 219

SP - 1989

EP - 1993

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 12

ER -

Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

Abstract

UN SDGs

Keywords

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Student theses

The human lung immune responses to nasopharyngeal pneumococcal colonisation in healthy adults

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