Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

Hugh Adler; Elissavet Nikolaou; Katherine Gould; Jason Hinds; Andrea Collins; Victoria Connor; Caz Hales; Helen Hill; Angela D. Hyder-Wright; Seher R. Zaidi; Esther German; Jenna F. Gritzfeld; Elena Mitsi; Sherin Pojar; Stephen Gordon; Adam Roberts; Jamie Rylance; Daniela Ferreira

doi:10.1093/infdis/jiz034

Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

Hugh Adler, Elissavet Nikolaou, Katherine Gould, Jason Hinds, Andrea Collins, Victoria Connor, Caz Hales, Helen Hill, Angela D. Hyder-Wright, Seher R. Zaidi, Esther German, Jenna F. Gritzfeld, Elena Mitsi, Sherin Pojar, Stephen Gordon, Adam Roberts, Jamie Rylance, Daniela Ferreira

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

Original language	English
Pages (from-to)	1989-1993
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	219
Issue number	12
Early online date	28 Jan 2019
DOIs	https://doi.org/10.1093/infdis/jiz034
Publication status	Published - 15 Jun 2019

Keywords

Drug resistance
Herd immunity
Microbial
Nasal washing
Streptococcus pneumoniae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiz034Licence: CC BY

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Adler, H., Nikolaou, E., Gould, K., Hinds, J., Collins, A., Connor, V., Hales, C., Hill, H., Hyder-Wright, A. D., Zaidi, S. R., German, E., Gritzfeld, J. F., Mitsi, E., Pojar, S., Gordon, S., Roberts, A., Rylance, J., & Ferreira, D. (2019). Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017. Journal of Infectious Diseases, 219(12), 1989-1993. https://doi.org/10.1093/infdis/jiz034

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abstract = "Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.",

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Adler, H, Nikolaou, E, Gould, K, Hinds, J, Collins, A, Connor, V, Hales, C, Hill, H, Hyder-Wright, AD, Zaidi, SR, German, E, Gritzfeld, JF, Mitsi, E, Pojar, S, Gordon, S , Roberts, A, Rylance, J & Ferreira, D 2019, 'Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017', Journal of Infectious Diseases, vol. 219, no. 12, pp. 1989-1993. https://doi.org/10.1093/infdis/jiz034

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T1 - Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

AU - Adler, Hugh

AU - Nikolaou, Elissavet

AU - Gould, Katherine

AU - Hinds, Jason

AU - Collins, Andrea

AU - Connor, Victoria

AU - Hales, Caz

AU - Hill, Helen

AU - Hyder-Wright, Angela D.

AU - Zaidi, Seher R.

AU - German, Esther

AU - Gritzfeld, Jenna F.

AU - Mitsi, Elena

AU - Pojar, Sherin

AU - Gordon, Stephen

AU - Roberts, Adam

AU - Rylance, Jamie

AU - Ferreira, Daniela

PY - 2019/6/15

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N2 - Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

AB - Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

KW - Drug resistance

KW - Herd immunity

KW - Microbial

KW - Nasal washing

KW - Streptococcus pneumoniae

U2 - 10.1093/infdis/jiz034

DO - 10.1093/infdis/jiz034

M3 - Article

SN - 0022-1899

VL - 219

SP - 1989

EP - 1993

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 12

ER -

Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

Abstract

Keywords

UN SDGs

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