Plasmodium falciparum transmission stages accumulate in the human bone marrow

R. Joice; S. K. Nilsson; Jacqui Montgomery; S. Dankwa; E. Egan; B. Morahan; K. B. Seydel; L. Bertuccini; P. Alano; K. C. Williamson; M. T. Duraisingh; T. E. Taylor; D. A. Milner; M. Marti

doi:10.1126/scitranslmed.3008882

Plasmodium falciparum transmission stages accumulate in the human bone marrow

R. Joice, S. K. Nilsson, Jacqui Montgomery, S. Dankwa, E. Egan, B. Morahan, K. B. Seydel, L. Bertuccini, P. Alano, K. C. Williamson, M. T. Duraisingh, T. E. Taylor, D. A. Milner, M. Marti

Tropical Disease Biology

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

235 Citations (Scopus)

Abstract

Transmission of Plasmodium falciparum malaria parasites requires formation and development of gametocytes, yet all but the most mature of these sexual parasite forms are absent from the blood circulation. We performed a systematic organ survey in pediatric cases of fatal malaria to characterize the spatial dynamics of gametocyte development in the human host. Histological studies revealed a niche in the extravascular space of the human bone marrow where gametocytes formed in erythroid precursor cells and underwent development before reentering the circulation. Accumulation of gametocytes in the hematopoietic system of human bone marrow did not rely on cytoadherence to the vasculature as does sequestration of asexual-stage parasites. This suggests a different mechanism for the sequestration of gametocytes that could potentially be exploited to block malaria transmission.

Original language	English
Article number	244re5
Pages (from-to)	244re5
Journal	Science Translational Medicine
Volume	6
Issue number	244
DOIs	https://doi.org/10.1126/scitranslmed.3008882
Publication status	Published - 1 Jul 2014

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Joice, R., Nilsson, S. K., Montgomery, J., Dankwa, S., Egan, E., Morahan, B., Seydel, K. B., Bertuccini, L., Alano, P., Williamson, K. C., Duraisingh, M. T., Taylor, T. E., Milner, D. A., & Marti, M. (2014). Plasmodium falciparum transmission stages accumulate in the human bone marrow. Science Translational Medicine, 6(244), 244re5. Article 244re5. https://doi.org/10.1126/scitranslmed.3008882

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title = "Plasmodium falciparum transmission stages accumulate in the human bone marrow",

abstract = "Transmission of Plasmodium falciparum malaria parasites requires formation and development of gametocytes, yet all but the most mature of these sexual parasite forms are absent from the blood circulation. We performed a systematic organ survey in pediatric cases of fatal malaria to characterize the spatial dynamics of gametocyte development in the human host. Histological studies revealed a niche in the extravascular space of the human bone marrow where gametocytes formed in erythroid precursor cells and underwent development before reentering the circulation. Accumulation of gametocytes in the hematopoietic system of human bone marrow did not rely on cytoadherence to the vasculature as does sequestration of asexual-stage parasites. This suggests a different mechanism for the sequestration of gametocytes that could potentially be exploited to block malaria transmission.",

author = "R. Joice and Nilsson, \{S. K.\} and Jacqui Montgomery and S. Dankwa and E. Egan and B. Morahan and Seydel, \{K. B.\} and L. Bertuccini and P. Alano and Williamson, \{K. C.\} and Duraisingh, \{M. T.\} and Taylor, \{T. E.\} and Milner, \{D. A.\} and M. Marti",

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Joice, R, Nilsson, SK, Montgomery, J, Dankwa, S, Egan, E, Morahan, B, Seydel, KB, Bertuccini, L, Alano, P, Williamson, KC, Duraisingh, MT, Taylor, TE, Milner, DA & Marti, M 2014, 'Plasmodium falciparum transmission stages accumulate in the human bone marrow', Science Translational Medicine, vol. 6, no. 244, 244re5, pp. 244re5. https://doi.org/10.1126/scitranslmed.3008882

TY - JOUR

T1 - Plasmodium falciparum transmission stages accumulate in the human bone marrow

AU - Joice, R.

AU - Nilsson, S. K.

AU - Montgomery, Jacqui

AU - Dankwa, S.

AU - Egan, E.

AU - Morahan, B.

AU - Seydel, K. B.

AU - Bertuccini, L.

AU - Alano, P.

AU - Williamson, K. C.

AU - Duraisingh, M. T.

AU - Taylor, T. E.

AU - Milner, D. A.

AU - Marti, M.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Transmission of Plasmodium falciparum malaria parasites requires formation and development of gametocytes, yet all but the most mature of these sexual parasite forms are absent from the blood circulation. We performed a systematic organ survey in pediatric cases of fatal malaria to characterize the spatial dynamics of gametocyte development in the human host. Histological studies revealed a niche in the extravascular space of the human bone marrow where gametocytes formed in erythroid precursor cells and underwent development before reentering the circulation. Accumulation of gametocytes in the hematopoietic system of human bone marrow did not rely on cytoadherence to the vasculature as does sequestration of asexual-stage parasites. This suggests a different mechanism for the sequestration of gametocytes that could potentially be exploited to block malaria transmission.

AB - Transmission of Plasmodium falciparum malaria parasites requires formation and development of gametocytes, yet all but the most mature of these sexual parasite forms are absent from the blood circulation. We performed a systematic organ survey in pediatric cases of fatal malaria to characterize the spatial dynamics of gametocyte development in the human host. Histological studies revealed a niche in the extravascular space of the human bone marrow where gametocytes formed in erythroid precursor cells and underwent development before reentering the circulation. Accumulation of gametocytes in the hematopoietic system of human bone marrow did not rely on cytoadherence to the vasculature as does sequestration of asexual-stage parasites. This suggests a different mechanism for the sequestration of gametocytes that could potentially be exploited to block malaria transmission.

U2 - 10.1126/scitranslmed.3008882

DO - 10.1126/scitranslmed.3008882

M3 - Article

SN - 1946-6234

VL - 6

SP - 244re5

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 244

M1 - 244re5

ER -

Plasmodium falciparum transmission stages accumulate in the human bone marrow

Abstract

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