Abstract
Lipoic acid is an essential cofactor of multienzyme complexes that are integral to energy metabolism, amino acid degradation and folate metabolism. In recent years it has been shown that the malaria parasite Plasmodium falciparum possesses organelle-specific pathways that guarantee the lipoylation of their multienzyme complexes which occur in the mitochondrion (LA salvage) and in a plastid-like organelle, the apicoplast (LA biosynthesis). The unique distribution of the lipoylation machineries and the unique metabolic requirements of the parasites present a situation that is potentially exploitable for new ways to improve malaria control.
| Original language | English |
|---|---|
| Pages (from-to) | 748-752 |
| Number of pages | 5 |
| Journal | International Journal of Biochemistry and Cell Biology |
| Volume | 41 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Apr 2009 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Apicoplast
- Drug target
- Lipoylation
- Malaria
- Mitochondrion
Fingerprint
Dive into the research topics of 'Plasmodium falciparum: Organelle-specific acquisition of lipoic acid: Organelle-specific acquisition of lipoic acid'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver