Plasmodium falciparum Icam-1-based cytoadherence-related signalling in endothelical cells

N. Jenkins; Yang Wu; S. Chakravorty; O. Kai; Kevin Marsh; Alister Craig

doi:10.1016/j.jinf.2008.01.018

Plasmodium falciparum Icam-1-based cytoadherence-related signalling in endothelical cells

N. Jenkins, Yang Wu, S. Chakravorty, O. Kai, Kevin Marsh, Alister Craig

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Cytoadherence of Plasmodium falciparum infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but despite extensive information on the primary processes involved in the adhesive interactions the mechanisms underlying disease are poorly understood. There is evidence that during cerebral malaria there is subtle, focal alteration in the integrity of the blood-brain barrier. Rather than being passive bystanders, we have considered how endothelial cells might respond to parasite binding with direct effects on barrier function.

Original language	English
Pages (from-to)	299-299
Journal	Journal of Infection
DOIs	https://doi.org/10.1016/j.jinf.2008.01.018
Publication status	Published - 1 Apr 2008

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10.1016/j.jinf.2008.01.018

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title = "Plasmodium falciparum Icam-1-based cytoadherence-related signalling in endothelical cells",

abstract = "Background: Cytoadherence of Plasmodium falciparum infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but despite extensive information on the primary processes involved in the adhesive interactions the mechanisms underlying disease are poorly understood. There is evidence that during cerebral malaria there is subtle, focal alteration in the integrity of the blood-brain barrier. Rather than being passive bystanders, we have considered how endothelial cells might respond to parasite binding with direct effects on barrier function.",

author = "N. Jenkins and Yang Wu and S. Chakravorty and O. Kai and Kevin Marsh and Alister Craig",

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AU - Jenkins, N.

AU - Wu, Yang

AU - Chakravorty, S.

AU - Kai, O.

AU - Marsh, Kevin

AU - Craig, Alister

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Background: Cytoadherence of Plasmodium falciparum infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but despite extensive information on the primary processes involved in the adhesive interactions the mechanisms underlying disease are poorly understood. There is evidence that during cerebral malaria there is subtle, focal alteration in the integrity of the blood-brain barrier. Rather than being passive bystanders, we have considered how endothelial cells might respond to parasite binding with direct effects on barrier function.

AB - Background: Cytoadherence of Plasmodium falciparum infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but despite extensive information on the primary processes involved in the adhesive interactions the mechanisms underlying disease are poorly understood. There is evidence that during cerebral malaria there is subtle, focal alteration in the integrity of the blood-brain barrier. Rather than being passive bystanders, we have considered how endothelial cells might respond to parasite binding with direct effects on barrier function.

U2 - 10.1016/j.jinf.2008.01.018

DO - 10.1016/j.jinf.2008.01.018

M3 - Article

SN - 0163-4453

SP - 299

EP - 299

JO - Journal of Infection

JF - Journal of Infection

ER -

Plasmodium falciparum Icam-1-based cytoadherence-related signalling in endothelical cells

Abstract

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