Plasma HIV burden in Malawian children co-infected with rotavirus

C. Jere; N. A. Cunliffe; I. F. Hoffman; P. W. Stewart; R. Kilaru; R. L. Broadhead; Malcolm E Molyneux; C. Anthony Hart; S. A. Fiscus

doi:10.1097/00002030-200107270-00016

Plasma HIV burden in Malawian children co-infected with rotavirus

C. Jere, N. A. Cunliffe, I. F. Hoffman, P. W. Stewart, R. Kilaru, R. L. Broadhead, Malcolm E Molyneux, C. Anthony Hart, S. A. Fiscus

Clinical Sciences

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Fifty-eight HIV-infected children with acute rotavirus diarrhea were tested for plasma HIV RNA. There was no difference between acute and convalescent mean viral loads, and little change in the CD4 cell counts. Compared with the 16 children who died within 4 weeks, 31 survivors had slightly lower viral loads at presentation and significantly higher CD4 cell counts. Low CD4 cell counts, but not HIV-1-RNA concentrations, were predictive of death. Local, enteric rotavirus infection did not appear to affect blood HIV viral load or CD4 cell counts in this small group of children.

Original language	English
Pages (from-to)	1439-1442
Number of pages	4
Journal	AIDS
Volume	15
Issue number	11
DOIs	https://doi.org/10.1097/00002030-200107270-00016
Publication status	Published - 27 Jul 2001

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10.1097/00002030-200107270-00016

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title = "Plasma HIV burden in Malawian children co-infected with rotavirus",

abstract = "Fifty-eight HIV-infected children with acute rotavirus diarrhea were tested for plasma HIV RNA. There was no difference between acute and convalescent mean viral loads, and little change in the CD4 cell counts. Compared with the 16 children who died within 4 weeks, 31 survivors had slightly lower viral loads at presentation and significantly higher CD4 cell counts. Low CD4 cell counts, but not HIV-1-RNA concentrations, were predictive of death. Local, enteric rotavirus infection did not appear to affect blood HIV viral load or CD4 cell counts in this small group of children.",

author = "C. Jere and Cunliffe, \{N. A.\} and Hoffman, \{I. F.\} and Stewart, \{P. W.\} and R. Kilaru and Broadhead, \{R. L.\} and Molyneux, \{Malcolm E\} and Hart, \{C. Anthony\} and Fiscus, \{S. A.\}",

year = "2001",

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doi = "10.1097/00002030-200107270-00016",

language = "English",

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TY - JOUR

T1 - Plasma HIV burden in Malawian children co-infected with rotavirus

AU - Jere, C.

AU - Cunliffe, N. A.

AU - Hoffman, I. F.

AU - Stewart, P. W.

AU - Kilaru, R.

AU - Broadhead, R. L.

AU - Molyneux, Malcolm E

AU - Hart, C. Anthony

AU - Fiscus, S. A.

PY - 2001/7/27

Y1 - 2001/7/27

N2 - Fifty-eight HIV-infected children with acute rotavirus diarrhea were tested for plasma HIV RNA. There was no difference between acute and convalescent mean viral loads, and little change in the CD4 cell counts. Compared with the 16 children who died within 4 weeks, 31 survivors had slightly lower viral loads at presentation and significantly higher CD4 cell counts. Low CD4 cell counts, but not HIV-1-RNA concentrations, were predictive of death. Local, enteric rotavirus infection did not appear to affect blood HIV viral load or CD4 cell counts in this small group of children.

AB - Fifty-eight HIV-infected children with acute rotavirus diarrhea were tested for plasma HIV RNA. There was no difference between acute and convalescent mean viral loads, and little change in the CD4 cell counts. Compared with the 16 children who died within 4 weeks, 31 survivors had slightly lower viral loads at presentation and significantly higher CD4 cell counts. Low CD4 cell counts, but not HIV-1-RNA concentrations, were predictive of death. Local, enteric rotavirus infection did not appear to affect blood HIV viral load or CD4 cell counts in this small group of children.

U2 - 10.1097/00002030-200107270-00016

DO - 10.1097/00002030-200107270-00016

M3 - Article

SN - 0269-9370

VL - 15

SP - 1439

EP - 1442

JO - AIDS

JF - AIDS

IS - 11

ER -

Plasma HIV burden in Malawian children co-infected with rotavirus

Abstract

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