Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria

Anna Van Eijk; Peter O. Ouma; John Williamson; Feiko Ter Kuile; Monica Parise; Kephas Otieno; Mary J. Hamel; John G. Ayisi; Simon Kariuki; Piet A. Kager; Laurence Slutsker

doi:10.1086/592715

Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria

Anna Van Eijk, Peter O. Ouma, John Williamson, Feiko Ter Kuile, Monica Parise, Kephas Otieno, Mary J. Hamel, John G. Ayisi, Simon Kariuki, Piet A. Kager, Laurence Slutsker

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate supplementation has on SP failure in 467 pregnant women were analyzed. Plasmafolate levels were determined at enrollment and at day 7. High baseline folate levels, high parasite densities, and age <20 years were risk factors for SP failure. High-dose (5 mg daily) folate supplementation or high folate levels at day 7 were independent risk factors. Therefore, pregnant women receiving SP should receive low-/moderate-dose folate supplementation.

Original language	English
Pages (from-to)	1550-1553
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	198
Issue number	10
DOIs	https://doi.org/10.1086/592715
Publication status	Published - 15 Nov 2008

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Van Eijk, A., Ouma, P. O., Williamson, J., Ter Kuile, F., Parise, M., Otieno, K., Hamel, M. J., Ayisi, J. G., Kariuki, S., Kager, P. A., & Slutsker, L. (2008). Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria. Journal of Infectious Diseases, 198(10), 1550-1553. https://doi.org/10.1086/592715

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title = "Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria",

abstract = "Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate supplementation has on SP failure in 467 pregnant women were analyzed. Plasmafolate levels were determined at enrollment and at day 7. High baseline folate levels, high parasite densities, and age <20 years were risk factors for SP failure. High-dose (5 mg daily) folate supplementation or high folate levels at day 7 were independent risk factors. Therefore, pregnant women receiving SP should receive low-/moderate-dose folate supplementation.",

author = "\{Van Eijk\}, Anna and Ouma, \{Peter O.\} and John Williamson and \{Ter Kuile\}, Feiko and Monica Parise and Kephas Otieno and Hamel, \{Mary J.\} and Ayisi, \{John G.\} and Simon Kariuki and Kager, \{Piet A.\} and Laurence Slutsker",

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Van Eijk, A, Ouma, PO, Williamson, J, Ter Kuile, F, Parise, M, Otieno, K, Hamel, MJ, Ayisi, JG, Kariuki, S, Kager, PA & Slutsker, L 2008, 'Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria', Journal of Infectious Diseases, vol. 198, no. 10, pp. 1550-1553. https://doi.org/10.1086/592715

Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria. / Van Eijk, Anna; Ouma, Peter O.; Williamson, John et al.
In: Journal of Infectious Diseases, Vol. 198, No. 10, 15.11.2008, p. 1550-1553.

Research output: Contribution to journal › Article › peer-review

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AU - Van Eijk, Anna

AU - Ouma, Peter O.

AU - Williamson, John

AU - Ter Kuile, Feiko

AU - Parise, Monica

AU - Otieno, Kephas

AU - Hamel, Mary J.

AU - Ayisi, John G.

AU - Kariuki, Simon

AU - Kager, Piet A.

AU - Slutsker, Laurence

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AB - Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate supplementation has on SP failure in 467 pregnant women were analyzed. Plasmafolate levels were determined at enrollment and at day 7. High baseline folate levels, high parasite densities, and age <20 years were risk factors for SP failure. High-dose (5 mg daily) folate supplementation or high folate levels at day 7 were independent risk factors. Therefore, pregnant women receiving SP should receive low-/moderate-dose folate supplementation.

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Plasma Folate Level and High-Dose Folate Supplementation Predict Sulfadoxine-Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria

Abstract

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