Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

Richard Fitzgerald; Laura Dickinson; Laura Else; Tom Fletcher; Colin Hale; Alieu Amara; Lauren Walker; Sujan Dilly Penchala; Rebecca Lyon; Victoria Shaw; William Greenhalf; Katie Bullock; Lara Lavelle-Langham; Helen Reynolds; Wendy Painter; Wayne Holman; Sean Ewings; Gareth Griffiths; Saye Khoo

doi:10.1093/cid/ciac199

Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

Richard Fitzgerald
, Laura Dickinson
, Laura Else
, Tom Fletcher
, Colin Hale
, Alieu Amara
, Lauren Walker
, Sujan Dilly Penchala
, Rebecca Lyon
, Victoria Shaw
, William Greenhalf
, Katie Bullock
, Lara Lavelle-Langham
, Helen Reynolds
, Wendy Painter
, Wayne Holman
, Sean Ewings
, Gareth Griffiths
, Saye Khoo

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21 and 22% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma (p<0.0001).

Original language	English
Pages (from-to)	e525-e528
Journal	Clinical Infectious Diseases
Volume	75
Issue number	1
Early online date	10 Mar 2022
DOIs	https://doi.org/10.1093/cid/ciac199
Publication status	Published - 1 Jul 2022

Keywords

COVID-19
molnupiravir
nonplasma
pharmacokinetics
SARS-CoV-2

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10.1093/cid/ciac199Licence: CC BY

Ciac199Final published version, 2.69 MBLicence: CC BY

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Fitzgerald, R., Dickinson, L., Else, L., Fletcher, T., Hale, C., Amara, A., Walker, L., Penchala, S. D., Lyon, R., Shaw, V., Greenhalf, W., Bullock, K., Lavelle-Langham, L., Reynolds, H., Painter, W., Holman, W., Ewings, S., Griffiths, G., & Khoo, S. (2022). Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection. Clinical Infectious Diseases, 75(1), e525-e528. https://doi.org/10.1093/cid/ciac199

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title = "Pharmacokinetics of {\ss}-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection",

abstract = "{\ss}-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21 and 22\% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma (p<0.0001).",

keywords = "COVID-19, molnupiravir, nonplasma, pharmacokinetics, SARS-CoV-2",

author = "Richard Fitzgerald and Laura Dickinson and Laura Else and Tom Fletcher and Colin Hale and Alieu Amara and Lauren Walker and Penchala, \{Sujan Dilly\} and Rebecca Lyon and Victoria Shaw and William Greenhalf and Katie Bullock and Lara Lavelle-Langham and Helen Reynolds and Wendy Painter and Wayne Holman and Sean Ewings and Gareth Griffiths and Saye Khoo",

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Fitzgerald, R, Dickinson, L, Else, L, Fletcher, T, Hale, C, Amara, A, Walker, L, Penchala, SD, Lyon, R, Shaw, V, Greenhalf, W, Bullock, K, Lavelle-Langham, L, Reynolds, H, Painter, W, Holman, W, Ewings, S, Griffiths, G & Khoo, S 2022, 'Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection', Clinical Infectious Diseases, vol. 75, no. 1, pp. e525-e528. https://doi.org/10.1093/cid/ciac199

TY - JOUR

T1 - Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

AU - Fitzgerald, Richard

AU - Dickinson, Laura

AU - Else, Laura

AU - Fletcher, Tom

AU - Hale, Colin

AU - Amara, Alieu

AU - Walker, Lauren

AU - Penchala, Sujan Dilly

AU - Lyon, Rebecca

AU - Shaw, Victoria

AU - Greenhalf, William

AU - Bullock, Katie

AU - Lavelle-Langham, Lara

AU - Reynolds, Helen

AU - Painter, Wendy

AU - Holman, Wayne

AU - Ewings, Sean

AU - Griffiths, Gareth

AU - Khoo, Saye

PY - 2022/7/1

Y1 - 2022/7/1

N2 - ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21 and 22% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma (p<0.0001).

AB - ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21 and 22% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma (p<0.0001).

KW - COVID-19

KW - molnupiravir

KW - nonplasma

KW - pharmacokinetics

KW - SARS-CoV-2

U2 - 10.1093/cid/ciac199

DO - 10.1093/cid/ciac199

M3 - Article

SN - 1058-4838

VL - 75

SP - e525-e528

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 1

ER -

Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

Abstract

Keywords

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