Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children.

Christopher A. Moxon; Ngawina V. Chisala; Samuel C. Wassmer; Terrie E. Taylor; Karl B. Seydel; Malcolm E. Molyneux; Brian Faragher; Neil Kennedy; Cheng Hock Toh; Alister Craig; Robert S. Heyderman

doi:10.1093/infdis/jit419

Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children.

Christopher A. Moxon, Ngawina V. Chisala, Samuel C. Wassmer, Terrie E. Taylor, Karl B. Seydel, Malcolm E. Molyneux, Brian Faragher, Neil Kennedy, Cheng Hock Toh, Alister Craig, Robert S. Heyderman

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

60 Citations (Scopus)

Abstract

Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.

Original language	English
Title of host publication	Journal of Infectious Diseases
Publisher	Oxford University Press
Pages	610-615
Number of pages	6
Volume	209
Edition	4
DOIs	https://doi.org/10.1093/infdis/jit419
Publication status	Published - 15 Feb 2014

Keywords

cardiovascular disease
endothelial activation
endothelial dysfunction
inflammation
pathogen burden
pediatric
Plasmodium falciparum
stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jit419Licence: CC BY

Jourinfectdis 209 4 610-615Final published version, 318 KBLicence: CC BY

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Moxon, C. A., Chisala, N. V., Wassmer, S. C., Taylor, T. E., Seydel, K. B., Molyneux, M. E., Faragher, B., Kennedy, N., Toh, C. H., Craig, A., & Heyderman, R. S. (2014). Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children. In Journal of Infectious Diseases (4 ed., Vol. 209, pp. 610-615). Oxford University Press. https://doi.org/10.1093/infdis/jit419

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abstract = "Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.",

keywords = "cardiovascular disease, endothelial activation, endothelial dysfunction, inflammation, pathogen burden, pediatric, Plasmodium falciparum, stroke",

author = "Moxon, \{Christopher A.\} and Chisala, \{Ngawina V.\} and Wassmer, \{Samuel C.\} and Taylor, \{Terrie E.\} and Seydel, \{Karl B.\} and Molyneux, \{Malcolm E.\} and Brian Faragher and Neil Kennedy and Toh, \{Cheng Hock\} and Alister Craig and Heyderman, \{Robert S.\}",

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doi = "10.1093/infdis/jit419",

language = "English",

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Moxon, CA, Chisala, NV, Wassmer, SC, Taylor, TE, Seydel, KB, Molyneux, ME, Faragher, B, Kennedy, N, Toh, CH, Craig, A & Heyderman, RS 2014, Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children. in Journal of Infectious Diseases. 4 edn, vol. 209, Oxford University Press, pp. 610-615. https://doi.org/10.1093/infdis/jit419

Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children. / Moxon, Christopher A.; Chisala, Ngawina V.; Wassmer, Samuel C. et al.
Journal of Infectious Diseases. Vol. 209 4. ed. Oxford University Press, 2014. p. 610-615.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children.

AU - Moxon, Christopher A.

AU - Chisala, Ngawina V.

AU - Wassmer, Samuel C.

AU - Taylor, Terrie E.

AU - Seydel, Karl B.

AU - Molyneux, Malcolm E.

AU - Faragher, Brian

AU - Kennedy, Neil

AU - Toh, Cheng Hock

AU - Craig, Alister

AU - Heyderman, Robert S.

PY - 2014/2/15

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N2 - Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.

AB - Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.

KW - cardiovascular disease

KW - endothelial activation

KW - endothelial dysfunction

KW - inflammation

KW - pathogen burden

KW - pediatric

KW - Plasmodium falciparum

KW - stroke

U2 - 10.1093/infdis/jit419

DO - 10.1093/infdis/jit419

M3 - Conference contribution

VL - 209

SP - 610

EP - 615

BT - Journal of Infectious Diseases

PB - Oxford University Press

ER -

Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children.

Abstract

Keywords

UN SDGs

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