Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

Patrick G. Bray; Michael P. Barrett; Steve Ward; Harry P. De Koning

doi:10.1016/s1471-4922(03)00069-2

Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

Patrick G. Bray, Michael P. Barrett, Steve Ward, Harry P. De Koning

Tropical Disease Biology

Research output: Contribution to journal › Review article › peer-review

225 Citations (Scopus)

Abstract

Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the pathogen, rather than the host cell; and acquired resistance is frequently the result of changes in transmembrane transport of the drug. Here, recent progress in elucidating the mechanisms of diamidine transport in three important protozoan pathogens, Trypanosoma brucei, Leishmania and Plasmodium falciparum, is reviewed, and the implications for drug resistance are discussed.

Original language	English
Pages (from-to)	232-239
Number of pages	8
Journal	Trends In Parasitology
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/s1471-4922(03)00069-2
Publication status	Published - 1 May 2003

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10.1016/s1471-4922(03)00069-2

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abstract = "Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the pathogen, rather than the host cell; and acquired resistance is frequently the result of changes in transmembrane transport of the drug. Here, recent progress in elucidating the mechanisms of diamidine transport in three important protozoan pathogens, Trypanosoma brucei, Leishmania and Plasmodium falciparum, is reviewed, and the implications for drug resistance are discussed.",

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AU - Bray, Patrick G.

AU - Barrett, Michael P.

AU - Ward, Steve

AU - De Koning, Harry P.

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N2 - Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the pathogen, rather than the host cell; and acquired resistance is frequently the result of changes in transmembrane transport of the drug. Here, recent progress in elucidating the mechanisms of diamidine transport in three important protozoan pathogens, Trypanosoma brucei, Leishmania and Plasmodium falciparum, is reviewed, and the implications for drug resistance are discussed.

AB - Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the pathogen, rather than the host cell; and acquired resistance is frequently the result of changes in transmembrane transport of the drug. Here, recent progress in elucidating the mechanisms of diamidine transport in three important protozoan pathogens, Trypanosoma brucei, Leishmania and Plasmodium falciparum, is reviewed, and the implications for drug resistance are discussed.

U2 - 10.1016/s1471-4922(03)00069-2

DO - 10.1016/s1471-4922(03)00069-2

M3 - Review article

SN - 1471-4922

VL - 19

SP - 232

EP - 239

JO - Trends In Parasitology

JF - Trends In Parasitology

IS - 5

ER -

Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

Abstract

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