Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens

Lyric C. Bartholomay; Robert M. Waterhouse; George F. Mayhew; Corey L. Campbell; Kristin Michel; Zhen Zou; Jose L. Ramirez; Suchismita Das; Kanwal Alvarez; Peter Arensburger; Bart Bryant; Sinead B. Chapman; Yuemei Dong; Sara M. Erickson; S. H.P. Parakrama Karunaratne; Vladimir Kokoza; Chinnappa D. Kodira; Patricia Pignatelli; Sang Woon Shin; Dana L. Vanlandingham; Peter W. Atkinson; Bruce Birren; George K. Christophides; Rollie J. Clem; Janet Hemingway; Stephen Higgs; Karine Megy; Hilary Ranson; Evgeny M. Zdobnov; Alexander S. Raikhel; Bruce M. Christensen; George Dimopoulos; Marc A.T. Muskavitch

doi:10.1126/science.1193162

Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens

Lyric C. Bartholomay
, Robert M. Waterhouse
, George F. Mayhew
, Corey L. Campbell
, Kristin Michel
, Zhen Zou
, Jose L. Ramirez
, Suchismita Das
, Kanwal Alvarez
, Peter Arensburger
, Bart Bryant
, Sinead B. Chapman
, Yuemei Dong
, Sara M. Erickson
, S. H.P. Parakrama Karunaratne
, Vladimir Kokoza
, Chinnappa D. Kodira
, Patricia Pignatelli
, Sang Woon Shin
, Dana L. Vanlandingham

Peter W. Atkinson, Bruce Birren, George K. Christophides, Rollie J. Clem, Janet Hemingway, Stephen Higgs, Karine Megy, Hilary Ranson, Evgeny M. Zdobnov, Alexander S. Raikhel, Bruce M. Christensen, George Dimopoulos, Marc A.T. Muskavitch

Vector Biology

Iowa State University
University of Geneva
Swiss Institute of Bioinformatics
Imperial College London
University of Wisconsin-Madison
Colorado State University
Kansas State University
University of California at Riverside
Johns Hopkins University
Broad Institute
Liverpool School of Tropical Medicine
University of Peradeniya
University of Texas Medical Branch at Galveston
European Molecular Biology Laboratory
Boston College
Harvard University

Research output: Contribution to journal › Article › peer-review

145 Citations (Scopus)

Abstract

The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.

Original language	English
Pages (from-to)	88-90
Number of pages	3
Journal	Science
Volume	330
Issue number	6000
DOIs	https://doi.org/10.1126/science.1193162
Publication status	Published - 1 Oct 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1126/science.1193162

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Bartholomay, L. C., Waterhouse, R. M., Mayhew, G. F., Campbell, C. L., Michel, K., Zou, Z., Ramirez, J. L., Das, S., Alvarez, K., Arensburger, P., Bryant, B., Chapman, S. B., Dong, Y., Erickson, S. M., Parakrama Karunaratne, S. H. P., Kokoza, V., Kodira, C. D., Pignatelli, P., Shin, S. W., ... Muskavitch, M. A. T. (2010). Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens. Science, 330(6000), 88-90. https://doi.org/10.1126/science.1193162

@article{e5ead5b2e9ea4f908abff2c565157a5d,

title = "Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens",

abstract = "The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.",

author = "Bartholomay, \{Lyric C.\} and Waterhouse, \{Robert M.\} and Mayhew, \{George F.\} and Campbell, \{Corey L.\} and Kristin Michel and Zhen Zou and Ramirez, \{Jose L.\} and Suchismita Das and Kanwal Alvarez and Peter Arensburger and Bart Bryant and Chapman, \{Sinead B.\} and Yuemei Dong and Erickson, \{Sara M.\} and \{Parakrama Karunaratne\}, \{S. H.P.\} and Vladimir Kokoza and Kodira, \{Chinnappa D.\} and Patricia Pignatelli and Shin, \{Sang Woon\} and Vanlandingham, \{Dana L.\} and Atkinson, \{Peter W.\} and Bruce Birren and Christophides, \{George K.\} and Clem, \{Rollie J.\} and Janet Hemingway and Stephen Higgs and Karine Megy and Hilary Ranson and Zdobnov, \{Evgeny M.\} and Raikhel, \{Alexander S.\} and Christensen, \{Bruce M.\} and George Dimopoulos and Muskavitch, \{Marc A.T.\}",

year = "2010",

month = oct,

day = "1",

doi = "10.1126/science.1193162",

language = "English",

volume = "330",

pages = "88--90",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6000",

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Bartholomay, LC, Waterhouse, RM, Mayhew, GF, Campbell, CL, Michel, K, Zou, Z, Ramirez, JL, Das, S, Alvarez, K, Arensburger, P, Bryant, B, Chapman, SB, Dong, Y, Erickson, SM, Parakrama Karunaratne, SHP, Kokoza, V, Kodira, CD, Pignatelli, P, Shin, SW, Vanlandingham, DL, Atkinson, PW, Birren, B, Christophides, GK, Clem, RJ, Hemingway, J, Higgs, S, Megy, K, Ranson, H, Zdobnov, EM, Raikhel, AS, Christensen, BM, Dimopoulos, G & Muskavitch, MAT 2010, 'Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens', Science, vol. 330, no. 6000, pp. 88-90. https://doi.org/10.1126/science.1193162

TY - JOUR

T1 - Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens

AU - Bartholomay, Lyric C.

AU - Waterhouse, Robert M.

AU - Mayhew, George F.

AU - Campbell, Corey L.

AU - Michel, Kristin

AU - Zou, Zhen

AU - Ramirez, Jose L.

AU - Das, Suchismita

AU - Alvarez, Kanwal

AU - Arensburger, Peter

AU - Bryant, Bart

AU - Chapman, Sinead B.

AU - Dong, Yuemei

AU - Erickson, Sara M.

AU - Parakrama Karunaratne, S. H.P.

AU - Kokoza, Vladimir

AU - Kodira, Chinnappa D.

AU - Pignatelli, Patricia

AU - Shin, Sang Woon

AU - Vanlandingham, Dana L.

AU - Atkinson, Peter W.

AU - Birren, Bruce

AU - Christophides, George K.

AU - Clem, Rollie J.

AU - Hemingway, Janet

AU - Higgs, Stephen

AU - Megy, Karine

AU - Ranson, Hilary

AU - Zdobnov, Evgeny M.

AU - Raikhel, Alexander S.

AU - Christensen, Bruce M.

AU - Dimopoulos, George

AU - Muskavitch, Marc A.T.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.

AB - The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.

U2 - 10.1126/science.1193162

DO - 10.1126/science.1193162

M3 - Article

SN - 0036-8075

VL - 330

SP - 88

EP - 90

JO - Science

JF - Science

IS - 6000

ER -

Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens

Abstract

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