Pathogenesis

Dorothee Heemskerk; Maxine Caws; Ben Marais; Jeremy Farrar

doi:10.1007/978-3-319-19132-4_2

Pathogenesis

Dorothee Heemskerk
, Maxine Caws
, Ben Marais
, Jeremy Farrar

Clinical Sciences

University of Oxford
The Children's Hospital at Westmead
Wellcome Trust

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

In this section the different phases of infection with Mycobacterium tuberculosis will be reviewed. Starting from transmission by inhalation, to the innate and adaptive immune response and the dual role of tuberculoma formation in walling off infection, but also providing an advantageous environment for bacilli to survive and multiply. Recent data has shown the role of Tumour Necrosis Factor alpha (TNF-α) in tuberculoma maintenance and its genetic control is more complex than previously thought. The role of vitamin D in susceptibility to tuberculosis also an area which has seen a resurgence of interest and new evidence emerging that targeted vitamin D therapy may have a role in improving TB outcomes.

Original language	English
Title of host publication	SpringerBriefs in Public Health
Pages	9-16
Number of pages	8
DOIs	https://doi.org/10.1007/978-3-319-19132-4_2
Publication status	Published - 1 Jan 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aadaptive immune response
Granuloma
Innate immune response
Interferron gamma (IFN)
Susceptibility
Transmission
Tuberculoma
Tumor necrosis factor (TNF)
Vitamin D

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10.1007/978-3-319-19132-4_2

Cite this

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abstract = "In this section the different phases of infection with Mycobacterium tuberculosis will be reviewed. Starting from transmission by inhalation, to the innate and adaptive immune response and the dual role of tuberculoma formation in walling off infection, but also providing an advantageous environment for bacilli to survive and multiply. Recent data has shown the role of Tumour Necrosis Factor alpha (TNF-α) in tuberculoma maintenance and its genetic control is more complex than previously thought. The role of vitamin D in susceptibility to tuberculosis also an area which has seen a resurgence of interest and new evidence emerging that targeted vitamin D therapy may have a role in improving TB outcomes.",

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AU - Caws, Maxine

AU - Marais, Ben

AU - Farrar, Jeremy

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AB - In this section the different phases of infection with Mycobacterium tuberculosis will be reviewed. Starting from transmission by inhalation, to the innate and adaptive immune response and the dual role of tuberculoma formation in walling off infection, but also providing an advantageous environment for bacilli to survive and multiply. Recent data has shown the role of Tumour Necrosis Factor alpha (TNF-α) in tuberculoma maintenance and its genetic control is more complex than previously thought. The role of vitamin D in susceptibility to tuberculosis also an area which has seen a resurgence of interest and new evidence emerging that targeted vitamin D therapy may have a role in improving TB outcomes.

KW - Aadaptive immune response

KW - Granuloma

KW - Innate immune response

KW - Interferron gamma (IFN)

KW - Susceptibility

KW - Transmission

KW - Tuberculoma

KW - Tumor necrosis factor (TNF)

KW - Vitamin D

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BT - SpringerBriefs in Public Health

ER -

Pathogenesis

Abstract

UN SDGs

Keywords

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