Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis.

James E. Scriven; Francois CJ Botha; Charlotte Schutz; David Lalloo; Helen Wainwright; Graeme Meintjes

doi:10.1016/j.mmcr.2017.02.004

Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis.

James E. Scriven
, Francois CJ Botha
, Charlotte Schutz
, David Lalloo
, Helen Wainwright
, Graeme Meintjes

University of Cape Town
Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms.

Original language	English
Pages (from-to)	38-40
Number of pages	3
Journal	Medical Mycology Case Reports
Volume	19
Early online date	17 Jan 2018
DOIs	https://doi.org/10.1016/j.mmcr.2017.02.004
Publication status	Published - 1 Mar 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Amphotericin B deoxycholate
Cryptococcal pneumonia
Cryptococcus neoformans
Paradoxical deterioration
Respiratory failure

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Medical mycology Paradoxical respiratory failureFinal published version, 490 KBLicence: CC BY

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title = "Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis.",

abstract = "We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms.",

keywords = "Amphotericin B deoxycholate, Cryptococcal pneumonia, Cryptococcus neoformans, Paradoxical deterioration, Respiratory failure",

author = "Scriven, \{James E.\} and Botha, \{Francois CJ\} and Charlotte Schutz and David Lalloo and Helen Wainwright and Graeme Meintjes",

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doi = "10.1016/j.mmcr.2017.02.004",

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T1 - Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis.

AU - Scriven, James E.

AU - Botha, Francois CJ

AU - Schutz, Charlotte

AU - Lalloo, David

AU - Wainwright, Helen

AU - Meintjes, Graeme

PY - 2018/3/1

Y1 - 2018/3/1

N2 - We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms.

AB - We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms.

KW - Amphotericin B deoxycholate

KW - Cryptococcal pneumonia

KW - Cryptococcus neoformans

KW - Paradoxical deterioration

KW - Respiratory failure

U2 - 10.1016/j.mmcr.2017.02.004

DO - 10.1016/j.mmcr.2017.02.004

M3 - Article

SN - 2211-7539

VL - 19

SP - 38

EP - 40

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

ER -

Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis.

Abstract

UN SDGs

Keywords

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