Other 4-Methanolquinolines, Amyl Alcohols and Phentathrenes: Mefloquine, Lumefantrine and Halofantrine

Francois Nosten; Penelope Phillips-Howard; Feiko Ter Kuile

doi:10.1007/978-3-0346-0480-2_5

Other 4-Methanolquinolines, Amyl Alcohols and Phentathrenes: Mefloquine, Lumefantrine and Halofantrine

Francois Nosten, Penelope Phillips-Howard, Feiko Ter Kuile

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter describes mefloquine, pyronaridine, halofantrine, piperaquine and lumefantrine under the broader title of the 4-methanolquinolines, amyl alcohols and phentathrenes. We provide a brief resume of each drug, in terms of their chemical properties, formulae, pharmacokinetics, clinical indications for use, and their efficacy and safety. Recognizing the limited number of antimalarials available, and in the developmental pipeline, attention is focussed on describing the history of each drug and how their indications have evolved as data on safety in human populations accumulates over time, and how patterns of use have changed with growing multiple drug resistance. Their combined use with the artemisinin derivatives is briefly described and readers are recommended to consult other chapters in this book which more fully describe such combinations.

Original language	English
Title of host publication	Treatment and Prevention of Malaria: anti-malarial drug chemistry, action and use.
Publisher	Springer
Pages	95-111
ISBN (Print)	9783034604796
DOIs	https://doi.org/10.1007/978-3-0346-0480-2_5
Publication status	Published - 1 Nov 2011

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abstract = "This chapter describes mefloquine, pyronaridine, halofantrine, piperaquine and lumefantrine under the broader title of the 4-methanolquinolines, amyl alcohols and phentathrenes. We provide a brief resume of each drug, in terms of their chemical properties, formulae, pharmacokinetics, clinical indications for use, and their efficacy and safety. Recognizing the limited number of antimalarials available, and in the developmental pipeline, attention is focussed on describing the history of each drug and how their indications have evolved as data on safety in human populations accumulates over time, and how patterns of use have changed with growing multiple drug resistance. Their combined use with the artemisinin derivatives is briefly described and readers are recommended to consult other chapters in this book which more fully describe such combinations.",

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Other 4-Methanolquinolines, Amyl Alcohols and Phentathrenes: Mefloquine, Lumefantrine and Halofantrine

Abstract

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