On the ancestral recruitment of metalloproteinases into the venom of snakes

Nick Casewell

doi:10.1016/j.toxicon.2012.02.006

On the ancestral recruitment of metalloproteinases into the venom of snakes

Nick Casewell

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.

Original language	English
Pages (from-to)	449-454
Number of pages	6
Journal	Toxicon
Volume	60
Issue number	4
DOIs	https://doi.org/10.1016/j.toxicon.2012.02.006
Publication status	Published - 15 Sept 2012

Keywords

ADAM
Ancestral reconstruction
Metalloproteinase
Molecular evolution
Serpentes
SVMP
Toxin
Venom

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10.1016/j.toxicon.2012.02.006

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abstract = "Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.",

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KW - Ancestral reconstruction

KW - Metalloproteinase

KW - Molecular evolution

KW - Serpentes

KW - SVMP

KW - Toxin

KW - Venom

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DO - 10.1016/j.toxicon.2012.02.006

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JO - Toxicon

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On the ancestral recruitment of metalloproteinases into the venom of snakes

Abstract

Keywords

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