Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort: Analysis of the ISARIC CCP-UK Cohort

Thomas Yates; Francesco Zaccardi; Nazrul Islam; Cameron Razieh; Clare L. Gillies; Claire A. Lawson; Yogini Chudasama; Alex Rowlands; Melanie J. Davies; Annemarie B. Docherty; Peter J.M. Openshaw; J. Kenneth Baillie; Malcolm G. Semple; Kamlesh Khunti; Gail Carson; Beatrice Alex; Benjamin Bach; Wendy S. Barclay; Debby Bogaert; Meera Chand; Graham S. Cooke; Jake Dunning; Ana da Silva Filipe; Tom Fletcher; Christopher A. Green; Ewen M. Harrison; Julian A. Hiscox; Antonia Ying Wai Ho; Peter W. Horby; Samreen Ijaz; Saye Khoo; Paul Klenerman; Andrew Law; Wei Shen Lim; Alexander J. Mentzer; Laura Merson; Alison M. Meynert; Mahdad Noursadeghi; Shona C. Moore; Massimo Palmarini; William A. Paxton; Georgios Pollakis; Nicholas Price; Andrew Rambaut; David L. Robertson; Clark D. Russell; Vanessa Sancho-Shimizu; Janet T. Scott; Louise Sigfrid; Tom Solomon

doi:10.1002/oby.23178

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort: Analysis of the ISARIC CCP-UK Cohort

Thomas Yates, Francesco Zaccardi, Nazrul Islam, Cameron Razieh, Clare L. Gillies, Claire A. Lawson, Yogini Chudasama, Alex Rowlands, Melanie J. Davies, Annemarie B. Docherty, Peter J.M. Openshaw, J. Kenneth Baillie, Malcolm G. Semple, Kamlesh Khunti, Gail Carson, Beatrice Alex, Benjamin Bach, Wendy S. Barclay, Debby Bogaert, Meera ChandGraham S. Cooke, Jake Dunning, Ana da Silva Filipe, Tom Fletcher, Christopher A. Green, Ewen M. Harrison, Julian A. Hiscox, Antonia Ying Wai Ho, Peter W. Horby, Samreen Ijaz, Saye Khoo, Paul Klenerman, Andrew Law, Wei Shen Lim, Alexander J. Mentzer, Laura Merson, Alison M. Meynert, Mahdad Noursadeghi, Shona C. Moore, Massimo Palmarini, William A. Paxton, Georgios Pollakis, Nicholas Price, Andrew Rambaut, David L. Robertson, Clark D. Russell, Vanessa Sancho-Shimizu, Janet T. Scott, Louise Sigfrid, Tom Solomon

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Objective: The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups. Methods: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases. Results: Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity. Conclusions: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.

Original language	English
Pages (from-to)	1223-1230
Number of pages	8
Journal	Obesity
Volume	29
Issue number	7
DOIs	https://doi.org/10.1002/oby.23178
Publication status	Published - 1 Jul 2021

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Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., Chudasama, Y., Rowlands, A., Davies, M. J., Docherty, A. B., Openshaw, P. J. M., Baillie, J. K., Semple, M. G., Khunti, K., Carson, G., Alex, B., Bach, B., Barclay, W. S., Bogaert, D., ... Solomon, T. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort: Analysis of the ISARIC CCP-UK Cohort. Obesity, 29(7), 1223-1230. https://doi.org/10.1002/oby.23178

@article{c00e9d4e0d2041e681cfd59a41a30b9d,

title = "Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort: Analysis of the ISARIC CCP-UK Cohort",

abstract = "Objective: The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups. Methods: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases. Results: Of the participants included, 54,254 (age = 76 years; 45.0\% women) were White, 3,728 (57 years; 41.1\% women) were South Asian, 2,523 (58 years; 44.9\% women) were Black, and 5,427 (61 years; 40.8\% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity. Conclusions: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.",

author = "Thomas Yates and Francesco Zaccardi and Nazrul Islam and Cameron Razieh and Gillies, \{Clare L.\} and Lawson, \{Claire A.\} and Yogini Chudasama and Alex Rowlands and Davies, \{Melanie J.\} and Docherty, \{Annemarie B.\} and Openshaw, \{Peter J.M.\} and Baillie, \{J. Kenneth\} and Semple, \{Malcolm G.\} and Kamlesh Khunti and Gail Carson and Beatrice Alex and Benjamin Bach and Barclay, \{Wendy S.\} and Debby Bogaert and Meera Chand and Cooke, \{Graham S.\} and Jake Dunning and \{da Silva Filipe\}, Ana and Tom Fletcher and Green, \{Christopher A.\} and Harrison, \{Ewen M.\} and Hiscox, \{Julian A.\} and Ho, \{Antonia Ying Wai\} and Horby, \{Peter W.\} and Samreen Ijaz and Saye Khoo and Paul Klenerman and Andrew Law and Lim, \{Wei Shen\} and Mentzer, \{Alexander J.\} and Laura Merson and Meynert, \{Alison M.\} and Mahdad Noursadeghi and Moore, \{Shona C.\} and Massimo Palmarini and Paxton, \{William A.\} and Georgios Pollakis and Nicholas Price and Andrew Rambaut and Robertson, \{David L.\} and Russell, \{Clark D.\} and Vanessa Sancho-Shimizu and Scott, \{Janet T.\} and Louise Sigfrid and Tom Solomon",

year = "2021",

month = jul,

day = "1",

doi = "10.1002/oby.23178",

language = "English",

volume = "29",

pages = "1223--1230",

journal = "Obesity",

issn = "1930-7381",

publisher = "John Wiley and Sons Inc",

number = "7",

}

Yates, T, Zaccardi, F, Islam, N, Razieh, C, Gillies, CL, Lawson, CA, Chudasama, Y, Rowlands, A, Davies, MJ, Docherty, AB, Openshaw, PJM, Baillie, JK, Semple, MG, Khunti, K, Carson, G, Alex, B, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Cooke, GS, Dunning, J, da Silva Filipe, A, Fletcher, T, Green, CA, Harrison, EM, Hiscox, JA, Ho, AYW, Horby, PW, Ijaz, S, Khoo, S, Klenerman, P, Law, A, Lim, WS, Mentzer, AJ, Merson, L, Meynert, AM, Noursadeghi, M, Moore, SC, Palmarini, M, Paxton, WA, Pollakis, G, Price, N, Rambaut, A, Robertson, DL, Russell, CD, Sancho-Shimizu, V, Scott, JT, Sigfrid, L & Solomon, T 2021, 'Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort: Analysis of the ISARIC CCP-UK Cohort', Obesity, vol. 29, no. 7, pp. 1223-1230. https://doi.org/10.1002/oby.23178

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort: Analysis of the ISARIC CCP-UK Cohort. / Yates, Thomas; Zaccardi, Francesco; Islam, Nazrul et al.
In: Obesity, Vol. 29, No. 7, 01.07.2021, p. 1223-1230.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort: Analysis of the ISARIC CCP-UK Cohort

AU - Yates, Thomas

AU - Zaccardi, Francesco

AU - Islam, Nazrul

AU - Razieh, Cameron

AU - Gillies, Clare L.

AU - Lawson, Claire A.

AU - Chudasama, Yogini

AU - Rowlands, Alex

AU - Davies, Melanie J.

AU - Docherty, Annemarie B.

AU - Openshaw, Peter J.M.

AU - Baillie, J. Kenneth

AU - Semple, Malcolm G.

AU - Khunti, Kamlesh

AU - Carson, Gail

AU - Alex, Beatrice

AU - Bach, Benjamin

AU - Barclay, Wendy S.

AU - Bogaert, Debby

AU - Chand, Meera

AU - Cooke, Graham S.

AU - Dunning, Jake

AU - da Silva Filipe, Ana

AU - Fletcher, Tom

AU - Green, Christopher A.

AU - Harrison, Ewen M.

AU - Hiscox, Julian A.

AU - Ho, Antonia Ying Wai

AU - Horby, Peter W.

AU - Ijaz, Samreen

AU - Khoo, Saye

AU - Klenerman, Paul

AU - Law, Andrew

AU - Lim, Wei Shen

AU - Mentzer, Alexander J.

AU - Merson, Laura

AU - Meynert, Alison M.

AU - Noursadeghi, Mahdad

AU - Moore, Shona C.

AU - Palmarini, Massimo

AU - Paxton, William A.

AU - Pollakis, Georgios

AU - Price, Nicholas

AU - Rambaut, Andrew

AU - Robertson, David L.

AU - Russell, Clark D.

AU - Sancho-Shimizu, Vanessa

AU - Scott, Janet T.

AU - Sigfrid, Louise

AU - Solomon, Tom

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Objective: The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups. Methods: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases. Results: Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity. Conclusions: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.

AB - Objective: The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups. Methods: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases. Results: Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity. Conclusions: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.

U2 - 10.1002/oby.23178

DO - 10.1002/oby.23178

M3 - Article

SN - 1930-7381

VL - 29

SP - 1223

EP - 1230

JO - Obesity

JF - Obesity

IS - 7

ER -