Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children.

A. M.D. Navaratnam; M. J. Mutumba-Nakalembe; Russell Stothard; N. B. Kabatereine; A. Fenwick; J. C. Sousa-Figueiredo

doi:10.1016/j.trstmh.2012.06.010

Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children.

A. M.D. Navaratnam, M. J. Mutumba-Nakalembe, Russell Stothard, N. B. Kabatereine, A. Fenwick, J. C. Sousa-Figueiredo

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Urine-dipstick diagnostic tests that detect schistosome circulating cathodic antigen (CCA) have the potential to provide more sensitive and rapid testing for intestinal schistosomiasis in field-based surveys; this is especially so when examining preschool children, from whom it may be difficult to obtain consecutive stool samples. To assess the performance of urine dipsticks, 569 preschool children from four villages along the shore of Lake Albert, Uganda, were screened for Schistosoma mansoni by Kato-Katz (K-K) examination of a single stool sample and CCA urine dipsticks. The prevalence of infection was 32.2% by K-K and 40.0% by CCA tests. Sensitivity and specificity were influenced by whether 'trace' results from the CCA test were characterised as positive or negative for infection with S. mansoni; ambiguities around this issue need to be resolved. Nevertheless, the CCA test showed particular promise for routine epidemiological screening in this setting.

Original language	English
Pages (from-to)	619-622
Number of pages	4
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	106
Issue number	10
DOIs	https://doi.org/10.1016/j.trstmh.2012.06.010
Publication status	Published - 1 Oct 2012

Keywords

Control programmes
Diagnostic scores
Diagnostic tests
Neglected tropical diseases
Rapid mapping
Schistosoma mansoni

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trstmh.2012.06.010

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title = "Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children.",

abstract = "Urine-dipstick diagnostic tests that detect schistosome circulating cathodic antigen (CCA) have the potential to provide more sensitive and rapid testing for intestinal schistosomiasis in field-based surveys; this is especially so when examining preschool children, from whom it may be difficult to obtain consecutive stool samples. To assess the performance of urine dipsticks, 569 preschool children from four villages along the shore of Lake Albert, Uganda, were screened for Schistosoma mansoni by Kato-Katz (K-K) examination of a single stool sample and CCA urine dipsticks. The prevalence of infection was 32.2\% by K-K and 40.0\% by CCA tests. Sensitivity and specificity were influenced by whether 'trace' results from the CCA test were characterised as positive or negative for infection with S. mansoni; ambiguities around this issue need to be resolved. Nevertheless, the CCA test showed particular promise for routine epidemiological screening in this setting.",

keywords = "Control programmes, Diagnostic scores, Diagnostic tests, Neglected tropical diseases, Rapid mapping, Schistosoma mansoni",

author = "Navaratnam, \{A. M.D.\} and Mutumba-Nakalembe, \{M. J.\} and Russell Stothard and Kabatereine, \{N. B.\} and A. Fenwick and Sousa-Figueiredo, \{J. C.\}",

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AU - Navaratnam, A. M.D.

AU - Mutumba-Nakalembe, M. J.

AU - Stothard, Russell

AU - Kabatereine, N. B.

AU - Fenwick, A.

AU - Sousa-Figueiredo, J. C.

PY - 2012/10/1

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AB - Urine-dipstick diagnostic tests that detect schistosome circulating cathodic antigen (CCA) have the potential to provide more sensitive and rapid testing for intestinal schistosomiasis in field-based surveys; this is especially so when examining preschool children, from whom it may be difficult to obtain consecutive stool samples. To assess the performance of urine dipsticks, 569 preschool children from four villages along the shore of Lake Albert, Uganda, were screened for Schistosoma mansoni by Kato-Katz (K-K) examination of a single stool sample and CCA urine dipsticks. The prevalence of infection was 32.2% by K-K and 40.0% by CCA tests. Sensitivity and specificity were influenced by whether 'trace' results from the CCA test were characterised as positive or negative for infection with S. mansoni; ambiguities around this issue need to be resolved. Nevertheless, the CCA test showed particular promise for routine epidemiological screening in this setting.

KW - Control programmes

KW - Diagnostic scores

KW - Diagnostic tests

KW - Neglected tropical diseases

KW - Rapid mapping

KW - Schistosoma mansoni

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ER -

Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children.

Abstract

Keywords

UN SDGs

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