Normal and malignant human colonic mucosa contain acidic and basic fibroblast growth factors

Mark Wilkinson; M. J. Gardner; P. W. Gould; B. A. Taylor; D. G. Fernig

doi:10.3892/ijo.3.5.933

Normal and malignant human colonic mucosa contain acidic and basic fibroblast growth factors

Mark Wilkinson, M. J. Gardner, P. W. Gould, B. A. Taylor, D. G. Fernig

University of Liverpool

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Quantification of the amount of heparin-binding growth factor activity present in homogenates of normal and malignant human colon mucosa in terms of basic fibroblast growth factor (bFGF) indicates that 6-29 ng/g tissue of bFGF-like activity was present in five samples of normal human colon and in five corresponding samples of malignant colon mucosa. Immunoblotting demonstrates the presence of immunoreactive bFGF and acidic fibroblast growth factor (aFGF). The presence of bFGF and aFGF in normal and malignant colon mucosa suggests that they may be involved not only in normal colon growth but also in the growth and survival of colon carcinomas.

Original language	English
Pages (from-to)	933-936
Number of pages	4
Journal	International Journal of Oncology
Volume	3
Issue number	5
DOIs	https://doi.org/10.3892/ijo.3.5.933
Publication status	Published - 1 Jan 1993
Externally published	Yes

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title = "Normal and malignant human colonic mucosa contain acidic and basic fibroblast growth factors",

abstract = "Quantification of the amount of heparin-binding growth factor activity present in homogenates of normal and malignant human colon mucosa in terms of basic fibroblast growth factor (bFGF) indicates that 6-29 ng/g tissue of bFGF-like activity was present in five samples of normal human colon and in five corresponding samples of malignant colon mucosa. Immunoblotting demonstrates the presence of immunoreactive bFGF and acidic fibroblast growth factor (aFGF). The presence of bFGF and aFGF in normal and malignant colon mucosa suggests that they may be involved not only in normal colon growth but also in the growth and survival of colon carcinomas.",

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year = "1993",

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doi = "10.3892/ijo.3.5.933",

language = "English",

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TY - JOUR

T1 - Normal and malignant human colonic mucosa contain acidic and basic fibroblast growth factors

AU - Wilkinson, Mark

AU - Gardner, M. J.

AU - Gould, P. W.

AU - Taylor, B. A.

AU - Fernig, D. G.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Quantification of the amount of heparin-binding growth factor activity present in homogenates of normal and malignant human colon mucosa in terms of basic fibroblast growth factor (bFGF) indicates that 6-29 ng/g tissue of bFGF-like activity was present in five samples of normal human colon and in five corresponding samples of malignant colon mucosa. Immunoblotting demonstrates the presence of immunoreactive bFGF and acidic fibroblast growth factor (aFGF). The presence of bFGF and aFGF in normal and malignant colon mucosa suggests that they may be involved not only in normal colon growth but also in the growth and survival of colon carcinomas.

AB - Quantification of the amount of heparin-binding growth factor activity present in homogenates of normal and malignant human colon mucosa in terms of basic fibroblast growth factor (bFGF) indicates that 6-29 ng/g tissue of bFGF-like activity was present in five samples of normal human colon and in five corresponding samples of malignant colon mucosa. Immunoblotting demonstrates the presence of immunoreactive bFGF and acidic fibroblast growth factor (aFGF). The presence of bFGF and aFGF in normal and malignant colon mucosa suggests that they may be involved not only in normal colon growth but also in the growth and survival of colon carcinomas.

U2 - 10.3892/ijo.3.5.933

DO - 10.3892/ijo.3.5.933

M3 - Article

SN - 1019-6439

VL - 3

SP - 933

EP - 936

JO - International Journal of Oncology

JF - International Journal of Oncology

IS - 5

ER -

Normal and malignant human colonic mucosa contain acidic and basic fibroblast growth factors

Abstract

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