Non-structural proteins of arthropod-borne bunyaviruses: Roles and functions: Roles and functions

Saleh Eifan; Esther Schnettler; Isabelle Dietrich; Alain Kohl; Anne Lie Blomström

doi:10.3390/v5102447

Non-structural proteins of arthropod-borne bunyaviruses: Roles and functions: Roles and functions

Saleh Eifan, Esther Schnettler, Isabelle Dietrich, Alain Kohl, Anne Lie Blomström

Research output: Contribution to journal › Review article › peer-review

60 Citations (Scopus)

Abstract

Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.

Original language	English
Pages (from-to)	2447-2468
Number of pages	22
Journal	Viruses
Volume	5
Issue number	10
DOIs	https://doi.org/10.3390/v5102447
Publication status	Published - 4 Oct 2013
Externally published	Yes

Keywords

Arbovirus
Bunyavirus
Host response
Non-structural protein
Virus replication

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10.3390/v5102447Licence: CC BY

Cite this

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title = "Non-structural proteins of arthropod-borne bunyaviruses: Roles and functions: Roles and functions",

abstract = "Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.",

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AU - Eifan, Saleh

AU - Schnettler, Esther

AU - Dietrich, Isabelle

AU - Kohl, Alain

AU - Blomström, Anne Lie

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.

AB - Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.

KW - Arbovirus

KW - Bunyavirus

KW - Host response

KW - Non-structural protein

KW - Virus replication

U2 - 10.3390/v5102447

DO - 10.3390/v5102447

M3 - Review article

SN - 1999-4915

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EP - 2468

JO - Viruses

JF - Viruses

IS - 10

ER -

Non-structural proteins of arthropod-borne bunyaviruses: Roles and functions: Roles and functions

Abstract

Keywords

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