Nitazoxanide is active against Mycobacterium leprae

Mai Ann Bailey; Hana Na; Malcolm S. Duthie; Thomas P. Gillis; Ramanuj Lahiri; Tanya Parish

doi:10.1371/journal.pone.0184107

Nitazoxanide is active against Mycobacterium leprae

Mai Ann Bailey
, Hana Na
, Malcolm S. Duthie
, Thomas P. Gillis
, Ramanuj Lahiri
, Tanya Parish

Infectious Disease Research Institute
Amgen Incorporated
National Hansen’s Disease Program

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.

Original language	English
Article number	e0184107
Journal	PLoS ONE
Volume	12
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0184107
Publication status	Published - 29 Aug 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1371/journal.pone.0184107

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abstract = "Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.",

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AU - Na, Hana

AU - Duthie, Malcolm S.

AU - Gillis, Thomas P.

AU - Lahiri, Ramanuj

AU - Parish, Tanya

PY - 2017/8/29

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AB - Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.

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DO - 10.1371/journal.pone.0184107

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Nitazoxanide is active against Mycobacterium leprae

Abstract

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