New ethical considerations in vaccine trials.

Known and novel pathogens continue to afflict the world's population, and we deploy existing and new vaccines - the best type of weapon we've got - against them. One consequence is that we are accumulating steadily more experience of both the scientific and the ethical requirements of conducting vaccine trials in people. Good science is itself an ethical requirement, as it is meaningless to apply ethical principles to a scientifically flawed product or plan. Bad science can only be bad ethics. And we have learned that ethical principles are a necessity when we apply the benefits of science to the improving of human health.

Recent epidemics have provided opportunities to expand our understanding of this field and of the many components of it that we recognize to be necessary to the ethical assessment of vaccines.