Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis

Newton Kalata; Jayne Ellis; Laura Benjamin; Samuel Kampondeni; Peter Chiodini; Thomas Harrison; David Lalloo; Robert S. Heyderman

doi:10.1186/s12879-021-06425-9

Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis

Newton Kalata
, Jayne Ellis
, Laura Benjamin
, Samuel Kampondeni
, Peter Chiodini
, Thomas Harrison
, David Lalloo
, Robert S. Heyderman

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background

Managing HIV-associated cryptococcal meningitis (CM) can become challenging in the presence of concurrent unusual central nervous system infections.

Case presentation

A 58-year old HIV infected woman new ART starter, who was being treated effectively for cryptococcal meningitis, represented with worsening of neurological symptoms. Brain MRI revealed a multicystic lesion in the left temporal lobe. Anti-fungal treatment was escalated for a suspected cryptococcoma, but post-mortem CSF serological test confirmed racemose neurocysticercosis.

Conclusion

Patients with HIV-associated CM are highly immunocompromised and may have multiple pathologies simultaneously. In endemic countries, neurocysticercosis should be considered in the differential diagnos

Original language	English
Article number	724
Journal	BMC Infectious Diseases
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12879-021-06425-9
Publication status	Published - 31 Jul 2021

Keywords

Cryptococcal meningitis
HIV
Racemose neurocysticercosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12879-021-06425-9Licence: CC BY

Neurological deterioration in a patient withs12879-021-06425-9Final published version, 647 KBLicence: CC BY

Cite this

Kalata, N., Ellis, J., Benjamin, L., Kampondeni, S., Chiodini, P., Harrison, T., Lalloo, D., & Heyderman, R. S. (2021). Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis. BMC Infectious Diseases, 21(1), Article 724. https://doi.org/10.1186/s12879-021-06425-9

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title = "Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis",

abstract = "BackgroundManaging HIV-associated cryptococcal meningitis (CM) can become challenging in the presence of concurrent unusual central nervous system infections.Case presentationA 58-year old HIV infected woman new ART starter, who was being treated effectively for cryptococcal meningitis, represented with worsening of neurological symptoms. Brain MRI revealed a multicystic lesion in the left temporal lobe. Anti-fungal treatment was escalated for a suspected cryptococcoma, but post-mortem CSF serological test confirmed racemose neurocysticercosis.ConclusionPatients with HIV-associated CM are highly immunocompromised and may have multiple pathologies simultaneously. In endemic countries, neurocysticercosis should be considered in the differential diagnos",

keywords = "Cryptococcal meningitis, HIV, Racemose neurocysticercosis",

author = "Newton Kalata and Jayne Ellis and Laura Benjamin and Samuel Kampondeni and Peter Chiodini and Thomas Harrison and David Lalloo and Heyderman, \{Robert S.\}",

year = "2021",

month = jul,

day = "31",

doi = "10.1186/s12879-021-06425-9",

language = "English",

volume = "21",

journal = "BMC Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central Ltd",

number = "1",

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Kalata, N, Ellis, J, Benjamin, L, Kampondeni, S, Chiodini, P, Harrison, T, Lalloo, D & Heyderman, RS 2021, 'Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis', BMC Infectious Diseases, vol. 21, no. 1, 724. https://doi.org/10.1186/s12879-021-06425-9

Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis. / Kalata, Newton; Ellis, Jayne; Benjamin, Laura et al.
In: BMC Infectious Diseases, Vol. 21, No. 1, 724, 31.07.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis

AU - Kalata, Newton

AU - Ellis, Jayne

AU - Benjamin, Laura

AU - Kampondeni, Samuel

AU - Chiodini, Peter

AU - Harrison, Thomas

AU - Lalloo, David

AU - Heyderman, Robert S.

PY - 2021/7/31

Y1 - 2021/7/31

N2 - BackgroundManaging HIV-associated cryptococcal meningitis (CM) can become challenging in the presence of concurrent unusual central nervous system infections.Case presentationA 58-year old HIV infected woman new ART starter, who was being treated effectively for cryptococcal meningitis, represented with worsening of neurological symptoms. Brain MRI revealed a multicystic lesion in the left temporal lobe. Anti-fungal treatment was escalated for a suspected cryptococcoma, but post-mortem CSF serological test confirmed racemose neurocysticercosis.ConclusionPatients with HIV-associated CM are highly immunocompromised and may have multiple pathologies simultaneously. In endemic countries, neurocysticercosis should be considered in the differential diagnos

AB - BackgroundManaging HIV-associated cryptococcal meningitis (CM) can become challenging in the presence of concurrent unusual central nervous system infections.Case presentationA 58-year old HIV infected woman new ART starter, who was being treated effectively for cryptococcal meningitis, represented with worsening of neurological symptoms. Brain MRI revealed a multicystic lesion in the left temporal lobe. Anti-fungal treatment was escalated for a suspected cryptococcoma, but post-mortem CSF serological test confirmed racemose neurocysticercosis.ConclusionPatients with HIV-associated CM are highly immunocompromised and may have multiple pathologies simultaneously. In endemic countries, neurocysticercosis should be considered in the differential diagnos

KW - Cryptococcal meningitis

KW - HIV

KW - Racemose neurocysticercosis

U2 - 10.1186/s12879-021-06425-9

DO - 10.1186/s12879-021-06425-9

M3 - Article

SN - 1471-2334

VL - 21

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

IS - 1

M1 - 724

ER -

Neurological deterioration in a patient with HIV-associated cryptococcal meningitis initially improving on antifungal treatment: a case report of coincidental racemose neurocysticercosis

Abstract

Keywords

UN SDGs

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