Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis

Héctor R. Morbidoni; Agustina I. de la Iglesia; Virginia Figueroa; Cecilia Di Capua; Thomas R. Ioerger; Tanya Parish

doi:10.1099/acmi.0.000070

Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis

Héctor R. Morbidoni
, Agustina I. de la Iglesia
, Virginia Figueroa
, Cecilia Di Capua
, Thomas R. Ioerger
, Tanya Parish

Universidad Nacional de Rosario
Texas A&M University
TB Discovery Research
Infectious Disease Research Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.

Original language	English
Article number	000070
Journal	Access Microbiology
Volume	1
Issue number	10
DOIs	https://doi.org/10.1099/acmi.0.000070
Publication status	Published - 1 Dec 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

econazole
Mycobacterium smegmatis
Mycobacterium tuberculosis
RshA

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10.1099/acmi.0.000070

Cite this

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title = "Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis",

abstract = "Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.",

keywords = "econazole, Mycobacterium smegmatis, Mycobacterium tuberculosis, RshA",

author = "Morbidoni, \{H{\'e}ctor R.\} and \{de la Iglesia\}, \{Agustina I.\} and Virginia Figueroa and \{Di Capua\}, Cecilia and Ioerger, \{Thomas R.\} and Tanya Parish",

year = "2019",

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day = "1",

doi = "10.1099/acmi.0.000070",

language = "English",

volume = "1",

journal = "Access Microbiology",

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TY - JOUR

T1 - Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis

AU - Morbidoni, Héctor R.

AU - de la Iglesia, Agustina I.

AU - Figueroa, Virginia

AU - Di Capua, Cecilia

AU - Ioerger, Thomas R.

AU - Parish, Tanya

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.

AB - Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.

KW - econazole

KW - Mycobacterium smegmatis

KW - Mycobacterium tuberculosis

KW - RshA

U2 - 10.1099/acmi.0.000070

DO - 10.1099/acmi.0.000070

M3 - Article

AN - SCOPUS:85218759422

SN - 2516-8290

VL - 1

JO - Access Microbiology

JF - Access Microbiology

IS - 10

M1 - 000070

ER -

Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis

Abstract

UN SDGs

Keywords

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