Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications.

Reem A Mubjer; Ahmed A Adeel; Michael Chance; Amir Hassan

doi:10.1186/1475-2875-10-245

Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications.

Reem A Mubjer, Ahmed A Adeel, Michael Chance, Amir Hassan

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

This is the first study to report baseline information on the characteristics and implications of anti-malarial drug resistance markers in Yemen. It is also the first report of the haplotype associated with CQR P. falciparum parasites from Yemen. Mutant pfcrtT76 is highly prevalent but it is a poor predictor of treatment failure in the study population. The prevalence of mutation dhfrArg59 is suggestive of emerging resistance to SP, which is currently a component of the recommended combination treatment of falciparum malaria in Yemen. More studies on these markers are recommended for surveillance of resistance in the study area.

Original language	English
Article number	245
Pages (from-to)	245
Journal	Malaria Journal
Volume	10
DOIs	https://doi.org/10.1186/1475-2875-10-245
Publication status	Published - 21 Aug 2011

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Chance-Malaria J-2011Final published version, 315 KBLicence: CC BY

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abstract = "This is the first study to report baseline information on the characteristics and implications of anti-malarial drug resistance markers in Yemen. It is also the first report of the haplotype associated with CQR P. falciparum parasites from Yemen. Mutant pfcrtT76 is highly prevalent but it is a poor predictor of treatment failure in the study population. The prevalence of mutation dhfrArg59 is suggestive of emerging resistance to SP, which is currently a component of the recommended combination treatment of falciparum malaria in Yemen. More studies on these markers are recommended for surveillance of resistance in the study area.",

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AB - This is the first study to report baseline information on the characteristics and implications of anti-malarial drug resistance markers in Yemen. It is also the first report of the haplotype associated with CQR P. falciparum parasites from Yemen. Mutant pfcrtT76 is highly prevalent but it is a poor predictor of treatment failure in the study population. The prevalence of mutation dhfrArg59 is suggestive of emerging resistance to SP, which is currently a component of the recommended combination treatment of falciparum malaria in Yemen. More studies on these markers are recommended for surveillance of resistance in the study area.

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Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications.

Abstract

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