Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria

Brenda Kwambana; Rahab C. Amaza; Catherine Okoi; Murtala Rabiu; Archibald Worwui; Ebenezer Foster-Nyarko; Bernard Ebruke; Abdul K. Sesay; Madikay Senghore; Abdullahi S. Umar; Rabi Usman; Adamu Atiku; Garba Abdullahi; Yahaya Buhari; Rabiu Sani; Husaini U. Bako; Bashir Abdullahi; Alliyu I. Yarima; Badaru Sikiru; Aderinola Olaolu Moses; Michael O. Popoola; Eme Ekeng; Adebola Olayinka; Nwando Mba; Adamu Kankia; Ibrahim N. Mamadu; Ifeanyi Okudo; Mary Stephen; Olivier Ronveaux; Jason Busuttil; Jason M. Mwenda; Mohammed Abdulaziz; Sulaiman A. Gummi; Adebayo Adedeji; Andre Bita; Linda Omar; Mamoudou Harouna Djingarey; Wondimagegnehu Alemu; Umberto D’Alessandro; Chikwe Ihekweazu; Martin Antonio

doi:10.1038/s41598-018-32475-2

Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria

Brenda Kwambana, Rahab C. Amaza, Catherine Okoi, Murtala Rabiu, Archibald Worwui, Ebenezer Foster-Nyarko, Bernard Ebruke, Abdul K. Sesay, Madikay Senghore, Abdullahi S. Umar, Rabi Usman, Adamu Atiku, Garba Abdullahi, Yahaya Buhari, Rabiu Sani, Husaini U. Bako, Bashir Abdullahi, Alliyu I. Yarima, Badaru Sikiru, Aderinola Olaolu MosesMichael O. Popoola, Eme Ekeng, Adebola Olayinka, Nwando Mba, Adamu Kankia, Ibrahim N. Mamadu, Ifeanyi Okudo, Mary Stephen, Olivier Ronveaux, Jason Busuttil, Jason M. Mwenda, Mohammed Abdulaziz, Sulaiman A. Gummi, Adebayo Adedeji, Andre Bita, Linda Omar, Mamoudou Harouna Djingarey, Wondimagegnehu Alemu, Umberto D’Alessandro, Chikwe Ihekweazu, Martin Antonio

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5–14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5–9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.

Original language	English
Article number	14194
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-32475-2
Publication status	Published - 1 Dec 2018
Externally published	Yes

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Kwambana, B., Amaza, R. C., Okoi, C., Rabiu, M., Worwui, A., Foster-Nyarko, E., Ebruke, B., Sesay, A. K., Senghore, M., Umar, A. S., Usman, R., Atiku, A., Abdullahi, G., Buhari, Y., Sani, R., Bako, H. U., Abdullahi, B., Yarima, A. I., Sikiru, B., ... Antonio, M. (2018). Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria. Scientific Reports, 8(1), Article 14194. https://doi.org/10.1038/s41598-018-32475-2

@article{bb4a20589ce148aa801d9036f1a55a6e,

title = "Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria",

abstract = "After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5–14 years accounted for 47\% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5–9 years was 10\%, double that reported among adults ≥ 30 years (5\%). NmC and pneumococcus accounted for 94\% (172/184) and 5\% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.",

author = "Brenda Kwambana and Amaza, \{Rahab C.\} and Catherine Okoi and Murtala Rabiu and Archibald Worwui and Ebenezer Foster-Nyarko and Bernard Ebruke and Sesay, \{Abdul K.\} and Madikay Senghore and Umar, \{Abdullahi S.\} and Rabi Usman and Adamu Atiku and Garba Abdullahi and Yahaya Buhari and Rabiu Sani and Bako, \{Husaini U.\} and Bashir Abdullahi and Yarima, \{Alliyu I.\} and Badaru Sikiru and Moses, \{Aderinola Olaolu\} and Popoola, \{Michael O.\} and Eme Ekeng and Adebola Olayinka and Nwando Mba and Adamu Kankia and Mamadu, \{Ibrahim N.\} and Ifeanyi Okudo and Mary Stephen and Olivier Ronveaux and Jason Busuttil and Mwenda, \{Jason M.\} and Mohammed Abdulaziz and Gummi, \{Sulaiman A.\} and Adebayo Adedeji and Andre Bita and Linda Omar and Djingarey, \{Mamoudou Harouna\} and Wondimagegnehu Alemu and Umberto D{\textquoteright}Alessandro and Chikwe Ihekweazu and Martin Antonio",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41598-018-32475-2",

language = "English",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

Kwambana, B, Amaza, RC, Okoi, C, Rabiu, M, Worwui, A, Foster-Nyarko, E, Ebruke, B, Sesay, AK, Senghore, M, Umar, AS, Usman, R, Atiku, A, Abdullahi, G, Buhari, Y, Sani, R, Bako, HU, Abdullahi, B, Yarima, AI, Sikiru, B, Moses, AO, Popoola, MO, Ekeng, E, Olayinka, A, Mba, N, Kankia, A, Mamadu, IN, Okudo, I, Stephen, M, Ronveaux, O, Busuttil, J, Mwenda, JM, Abdulaziz, M, Gummi, SA, Adedeji, A, Bita, A, Omar, L, Djingarey, MH, Alemu, W, D’Alessandro, U, Ihekweazu, C & Antonio, M 2018, 'Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria', Scientific Reports, vol. 8, no. 1, 14194. https://doi.org/10.1038/s41598-018-32475-2

TY - JOUR

T1 - Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria

AU - Kwambana, Brenda

AU - Amaza, Rahab C.

AU - Okoi, Catherine

AU - Rabiu, Murtala

AU - Worwui, Archibald

AU - Foster-Nyarko, Ebenezer

AU - Ebruke, Bernard

AU - Sesay, Abdul K.

AU - Senghore, Madikay

AU - Umar, Abdullahi S.

AU - Usman, Rabi

AU - Atiku, Adamu

AU - Abdullahi, Garba

AU - Buhari, Yahaya

AU - Sani, Rabiu

AU - Bako, Husaini U.

AU - Abdullahi, Bashir

AU - Yarima, Alliyu I.

AU - Sikiru, Badaru

AU - Moses, Aderinola Olaolu

AU - Popoola, Michael O.

AU - Ekeng, Eme

AU - Olayinka, Adebola

AU - Mba, Nwando

AU - Kankia, Adamu

AU - Mamadu, Ibrahim N.

AU - Okudo, Ifeanyi

AU - Stephen, Mary

AU - Ronveaux, Olivier

AU - Busuttil, Jason

AU - Mwenda, Jason M.

AU - Abdulaziz, Mohammed

AU - Gummi, Sulaiman A.

AU - Adedeji, Adebayo

AU - Bita, Andre

AU - Omar, Linda

AU - Djingarey, Mamoudou Harouna

AU - Alemu, Wondimagegnehu

AU - D’Alessandro, Umberto

AU - Ihekweazu, Chikwe

AU - Antonio, Martin

PY - 2018/12/1

Y1 - 2018/12/1

N2 - After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5–14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5–9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.

AB - After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5–14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5–9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.

U2 - 10.1038/s41598-018-32475-2

DO - 10.1038/s41598-018-32475-2

M3 - Article

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 14194

ER -

Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria

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