Mechanisms of chloroquine resistance in malarial chemotherapy

Steve Ward

doi:10.1016/0165-6147(88)90153-8

Mechanisms of chloroquine resistance in malarial chemotherapy

Steve Ward

Tropical Disease Biology

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

Malaria is a protozoan parasitic infection threatening millions of people throughout the world. Over 6 million cases of malaria are treated annually and in Africa alone one million infant deaths can be attributed directly to malaria. Chloroquine has been the mainstay of malaria chemotherapy for nearly 50 years, but widespread resistance now limits its usefulness. Stephen Ward outlines the pharmacology of this drug. possible mechanisms of parasite resistance and pharmacologically based strategies that may be useful in attempting to override this resistance.

Original language	English
Pages (from-to)	241-246
Number of pages	6
Journal	Trends in Pharmacological Sciences
Volume	9
Issue number	7
DOIs	https://doi.org/10.1016/0165-6147(88)90153-8
Publication status	Published - 1 Jul 1988

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10.1016/0165-6147(88)90153-8

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title = "Mechanisms of chloroquine resistance in malarial chemotherapy",

abstract = "Malaria is a protozoan parasitic infection threatening millions of people throughout the world. Over 6 million cases of malaria are treated annually and in Africa alone one million infant deaths can be attributed directly to malaria. Chloroquine has been the mainstay of malaria chemotherapy for nearly 50 years, but widespread resistance now limits its usefulness. Stephen Ward outlines the pharmacology of this drug. possible mechanisms of parasite resistance and pharmacologically based strategies that may be useful in attempting to override this resistance.",

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N2 - Malaria is a protozoan parasitic infection threatening millions of people throughout the world. Over 6 million cases of malaria are treated annually and in Africa alone one million infant deaths can be attributed directly to malaria. Chloroquine has been the mainstay of malaria chemotherapy for nearly 50 years, but widespread resistance now limits its usefulness. Stephen Ward outlines the pharmacology of this drug. possible mechanisms of parasite resistance and pharmacologically based strategies that may be useful in attempting to override this resistance.

AB - Malaria is a protozoan parasitic infection threatening millions of people throughout the world. Over 6 million cases of malaria are treated annually and in Africa alone one million infant deaths can be attributed directly to malaria. Chloroquine has been the mainstay of malaria chemotherapy for nearly 50 years, but widespread resistance now limits its usefulness. Stephen Ward outlines the pharmacology of this drug. possible mechanisms of parasite resistance and pharmacologically based strategies that may be useful in attempting to override this resistance.

U2 - 10.1016/0165-6147(88)90153-8

DO - 10.1016/0165-6147(88)90153-8

M3 - Review article

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SP - 241

EP - 246

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 7

ER -

Mechanisms of chloroquine resistance in malarial chemotherapy

Abstract

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