Measuring the effects of pesticides on occupationally exposed humans with the comet assay

S. M. Piperakis; Nadia Kontogianni; C. Siffel; M. M. Piperakis

doi:10.1002/tox.20191

Measuring the effects of pesticides on occupationally exposed humans with the comet assay

S. M. Piperakis, Nadia Kontogianni, C. Siffel, M. M. Piperakis

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

In this study we examine the effects of a mixture of pesticides on occupationally exposed agricultural workers. The study was performed on 149 people, 84 agricultural workers and 65 healthy men from the same area, who served as the control group. The exposed group was divided into a subgroup with 65 individuals moderately exposed (39 men and 26 women) and a highly exposed subgroup consisted of 19 men. The statistical analysis of the comet assay results showed that there were no significant differences in basal DNA damage between pesticide-exposed workers and the control group nor between moderately and highly exposed ones. In addition, exposure of peripheral blood lymphocytes to hydrogen peroxide or 7-irradiation led to a similar degree of DNA damage and subsequent repair for all the studied populations.

Original language	English
Pages (from-to)	355-359
Number of pages	5
Journal	Environmental Toxicology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1002/tox.20191
Publication status	Published - 1 Jan 2006
Externally published	Yes

Keywords

Comet assay
DNA damage
DNA repair
Human lymphocytes
Pesticides

Access to Document

10.1002/tox.20191

Cite this

@article{f2f1d421aaf14144ae3a2f7840b5e0c4,

title = "Measuring the effects of pesticides on occupationally exposed humans with the comet assay",

abstract = "In this study we examine the effects of a mixture of pesticides on occupationally exposed agricultural workers. The study was performed on 149 people, 84 agricultural workers and 65 healthy men from the same area, who served as the control group. The exposed group was divided into a subgroup with 65 individuals moderately exposed (39 men and 26 women) and a highly exposed subgroup consisted of 19 men. The statistical analysis of the comet assay results showed that there were no significant differences in basal DNA damage between pesticide-exposed workers and the control group nor between moderately and highly exposed ones. In addition, exposure of peripheral blood lymphocytes to hydrogen peroxide or 7-irradiation led to a similar degree of DNA damage and subsequent repair for all the studied populations.",

keywords = "Comet assay, DNA damage, DNA repair, Human lymphocytes, Pesticides",

author = "Piperakis, \{S. M.\} and Nadia Kontogianni and C. Siffel and Piperakis, \{M. M.\}",

year = "2006",

month = jan,

day = "1",

doi = "10.1002/tox.20191",

language = "English",

volume = "21",

pages = "355--359",

journal = "Environmental Toxicology",

issn = "1520-4081",

publisher = "John Wiley \& Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Measuring the effects of pesticides on occupationally exposed humans with the comet assay

AU - Piperakis, S. M.

AU - Kontogianni, Nadia

AU - Siffel, C.

AU - Piperakis, M. M.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - In this study we examine the effects of a mixture of pesticides on occupationally exposed agricultural workers. The study was performed on 149 people, 84 agricultural workers and 65 healthy men from the same area, who served as the control group. The exposed group was divided into a subgroup with 65 individuals moderately exposed (39 men and 26 women) and a highly exposed subgroup consisted of 19 men. The statistical analysis of the comet assay results showed that there were no significant differences in basal DNA damage between pesticide-exposed workers and the control group nor between moderately and highly exposed ones. In addition, exposure of peripheral blood lymphocytes to hydrogen peroxide or 7-irradiation led to a similar degree of DNA damage and subsequent repair for all the studied populations.

AB - In this study we examine the effects of a mixture of pesticides on occupationally exposed agricultural workers. The study was performed on 149 people, 84 agricultural workers and 65 healthy men from the same area, who served as the control group. The exposed group was divided into a subgroup with 65 individuals moderately exposed (39 men and 26 women) and a highly exposed subgroup consisted of 19 men. The statistical analysis of the comet assay results showed that there were no significant differences in basal DNA damage between pesticide-exposed workers and the control group nor between moderately and highly exposed ones. In addition, exposure of peripheral blood lymphocytes to hydrogen peroxide or 7-irradiation led to a similar degree of DNA damage and subsequent repair for all the studied populations.

KW - Comet assay

KW - DNA damage

KW - DNA repair

KW - Human lymphocytes

KW - Pesticides

U2 - 10.1002/tox.20191

DO - 10.1002/tox.20191

M3 - Article

SN - 1520-4081

VL - 21

SP - 355

EP - 359

JO - Environmental Toxicology

JF - Environmental Toxicology

IS - 4

ER -

Measuring the effects of pesticides on occupationally exposed humans with the comet assay

Abstract

Keywords

Access to Document

Fingerprint

Cite this