Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)

Samantha Donnellan; Carmen Martínez-Rodríguez; Ghaith Aljayyoussi; Giancarlo Biagini

doi:10.1007/978-1-0716-1358-0_23

Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)

Samantha Donnellan
, Carmen Martínez-Rodríguez
, Ghaith Aljayyoussi
, Giancarlo Biagini

Tropical Disease Biology

Liverpool School of Tropical Medicine
University of Liverpool

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world’s population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells. This chapter will describe a newly developed preclinical drug screening assay for TB, using high content imaging and pharmacokinetic/pharmacodynamic modeling.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Springer
Pages	393-408
Number of pages	16
ISBN (Electronic)	1940-6029
ISBN (Print)	1064-3745
DOIs	https://doi.org/10.1007/978-1-0716-1358-0_23
Publication status	E-pub ahead of print - 24 Jun 2021

Publication series

Name	Methods in Molecular Biology
Publisher	Humana Press Inc.
ISSN (Print)	1064-3745

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antibiotics
Drug screening
Mycobacteria
Pharmacokinetic and pharmacodynamic drug Modeling
Tuberculosis

Access to Document

10.1007/978-1-0716-1358-0_23

Cite this

Donnellan, S., Martínez-Rodríguez, C., Aljayyoussi, G., & Biagini, G. (2021). Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi). In Methods in Molecular Biology (pp. 393-408). (Methods in Molecular Biology). Springer. Advance online publication. https://doi.org/10.1007/978-1-0716-1358-0_23

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keywords = "Antibiotics, Drug screening, Mycobacteria, Pharmacokinetic and pharmacodynamic drug Modeling, Tuberculosis",

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Donnellan, S, Martínez-Rodríguez, C, Aljayyoussi, G & Biagini, G 2021, Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi). in Methods in Molecular Biology. Methods in Molecular Biology, Springer, pp. 393-408. https://doi.org/10.1007/978-1-0716-1358-0_23

Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi). / Donnellan, Samantha; Martínez-Rodríguez, Carmen; Aljayyoussi, Ghaith et al.
Methods in Molecular Biology. Springer, 2021. p. 393-408 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)

AU - Donnellan, Samantha

AU - Martínez-Rodríguez, Carmen

AU - Aljayyoussi, Ghaith

AU - Biagini, Giancarlo

PY - 2021/6/24

Y1 - 2021/6/24

N2 - The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world’s population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells. This chapter will describe a newly developed preclinical drug screening assay for TB, using high content imaging and pharmacokinetic/pharmacodynamic modeling.

AB - The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world’s population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells. This chapter will describe a newly developed preclinical drug screening assay for TB, using high content imaging and pharmacokinetic/pharmacodynamic modeling.

KW - Antibiotics

KW - Drug screening

KW - Mycobacteria

KW - Pharmacokinetic and pharmacodynamic drug Modeling

KW - Tuberculosis

U2 - 10.1007/978-1-0716-1358-0_23

DO - 10.1007/978-1-0716-1358-0_23

M3 - Chapter

SN - 1064-3745

T3 - Methods in Molecular Biology

SP - 393

EP - 408

BT - Methods in Molecular Biology

PB - Springer

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Donnellan S, Martínez-Rodríguez C, Aljayyoussi G, Biagini G. Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi). In Methods in Molecular Biology. Springer. 2021. p. 393-408. (Methods in Molecular Biology). Epub 2021 Jun 24. doi: 10.1007/978-1-0716-1358-0_23

Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)

Abstract

Publication series

UN SDGs

Keywords

Access to Document

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Cite this