Management of Sepsis

Sharon Nyesiga; Bayodé Roméo Adegbite; Priscilla Haguma; Emmanuel Nsutebu; Jamie Rylance; Shevin T. Jacob

doi:10.1017/9781009052733.018

Management of Sepsis

Sharon Nyesiga
, Bayodé Roméo Adegbite
, Priscilla Haguma
, Emmanuel Nsutebu
, Jamie Rylance
, Shevin T. Jacob

Clinical Sciences

Uganda Heart Institute
World Alliance for Lung and Intensive care Medicine in Uganda (WALIMU)
Centre de Recherche Médical de Lambaréné (CERMEL)
African Sepsis Alliance
Department of Clinical Sciences
African Sepsis Alliance

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer et al. 2016). It manifests as a spectrum of disease characterized by a progression from sepsis to septic shock. Though it has been historically characterized as a severe condition resulting from Gram-negative bacteraemia, sepsis may be the final common pathway to death of many life-threatening infections. Causative pathogens include a wide range of bacteria, viruses, fungi and parasites, and epidemic-prone diseases such as meningococcal meningitis, Ebola Virus Disease (EVD) or COVID-19 can sometimes be detected as outbreaks of sepsis.

Original language	English
Title of host publication	Principles of Medicine in Africa
Publisher	Cambridge University Press (CUP)
Pages	202-208
Number of pages	7
ISBN (Electronic)	9781316511435
ISBN (Print)	9781009052733
DOIs	https://doi.org/10.1017/9781009052733.018
Publication status	Published - 18 Jun 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1017/9781009052733.018

Cite this

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AU - Haguma, Priscilla

AU - Nsutebu, Emmanuel

AU - Rylance, Jamie

AU - Jacob, Shevin T.

PY - 2025/6/18

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AB - Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer et al. 2016). It manifests as a spectrum of disease characterized by a progression from sepsis to septic shock. Though it has been historically characterized as a severe condition resulting from Gram-negative bacteraemia, sepsis may be the final common pathway to death of many life-threatening infections. Causative pathogens include a wide range of bacteria, viruses, fungi and parasites, and epidemic-prone diseases such as meningococcal meningitis, Ebola Virus Disease (EVD) or COVID-19 can sometimes be detected as outbreaks of sepsis.

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M3 - Chapter

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EP - 208

BT - Principles of Medicine in Africa

PB - Cambridge University Press (CUP)

ER -

Management of Sepsis

Abstract

UN SDGs

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