Levels of DNA Adducts in the Blood and Follicular Fluid of Women Undergoing In Vitro Fertilization Treatment and Its Correlation with the Pregnancy Outcome

I. Al-Saleh; I. El-Doush; J. Arif; S. Coskun; K. Jaroudi; A. Al-Shahrani; Gamal Mohamed

doi:10.1007/s00128-009-9889-z

Levels of DNA Adducts in the Blood and Follicular Fluid of Women Undergoing In Vitro Fertilization Treatment and Its Correlation with the Pregnancy Outcome

I. Al-Saleh, I. El-Doush, J. Arif, S. Coskun, K. Jaroudi, A. Al-Shahrani, Gamal Mohamed

Tropical Disease Biology

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

This study is designed to investigate the impact of DNA damage on pregnancy and fertilization rate outcome in a sub-sample of women undergoing IVF treatment. Blood and follicular fluid samples (n = 60) were analyzed for DNA adducts. While no BPDE-DNA adducts were detected, other unknown lipophilic adducts were seen in blood and follicular fluid. Women who failed to achieve pregnancy had higher DNA adducts in follicular fluid than those who succeeded (p < 0.05). Follicular fluid cotinine levels were associated with DNA adduct levels in blood and follicular fluid (p < 0.05). Evaluation of DNA damage resulting from oxidative stress could have a role in predicting IVF success rate. © 2009 Springer Science+Business Media, LLC.

Original language	English
Pages (from-to)	23-28
Number of pages	6
Journal	Bulletin of Environmental Contamination and Toxicology
Volume	84
Issue number	1
DOIs	https://doi.org/10.1007/s00128-009-9889-z
Publication status	Published - 10 Oct 2010

Keywords

P-Postlabeling technique
DNA adducts
Fertilization rate
In vitro fertilization
Pregnancy outcome
Saudi Arabia

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BECT IVF and adductOther version, 2.26 MB

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Al-Saleh, I., El-Doush, I., Arif, J., Coskun, S., Jaroudi, K., Al-Shahrani, A., & Mohamed, G. (2010). Levels of DNA Adducts in the Blood and Follicular Fluid of Women Undergoing In Vitro Fertilization Treatment and Its Correlation with the Pregnancy Outcome. Bulletin of Environmental Contamination and Toxicology, 84(1), 23-28. https://doi.org/10.1007/s00128-009-9889-z

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abstract = "This study is designed to investigate the impact of DNA damage on pregnancy and fertilization rate outcome in a sub-sample of women undergoing IVF treatment. Blood and follicular fluid samples (n = 60) were analyzed for DNA adducts. While no BPDE-DNA adducts were detected, other unknown lipophilic adducts were seen in blood and follicular fluid. Women who failed to achieve pregnancy had higher DNA adducts in follicular fluid than those who succeeded (p < 0.05). Follicular fluid cotinine levels were associated with DNA adduct levels in blood and follicular fluid (p < 0.05). Evaluation of DNA damage resulting from oxidative stress could have a role in predicting IVF success rate. {\textcopyright} 2009 Springer Science+Business Media, LLC.",

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author = "I. Al-Saleh and I. El-Doush and J. Arif and S. Coskun and K. Jaroudi and A. Al-Shahrani and Gamal Mohamed",

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Al-Saleh, I, El-Doush, I, Arif, J, Coskun, S, Jaroudi, K, Al-Shahrani, A & Mohamed, G 2010, 'Levels of DNA Adducts in the Blood and Follicular Fluid of Women Undergoing In Vitro Fertilization Treatment and Its Correlation with the Pregnancy Outcome', Bulletin of Environmental Contamination and Toxicology, vol. 84, no. 1, pp. 23-28. https://doi.org/10.1007/s00128-009-9889-z

TY - JOUR

T1 - Levels of DNA Adducts in the Blood and Follicular Fluid of Women Undergoing In Vitro Fertilization Treatment and Its Correlation with the Pregnancy Outcome

AU - Al-Saleh, I.

AU - El-Doush, I.

AU - Arif, J.

AU - Coskun, S.

AU - Jaroudi, K.

AU - Al-Shahrani, A.

AU - Mohamed, Gamal

PY - 2010/10/10

Y1 - 2010/10/10

N2 - This study is designed to investigate the impact of DNA damage on pregnancy and fertilization rate outcome in a sub-sample of women undergoing IVF treatment. Blood and follicular fluid samples (n = 60) were analyzed for DNA adducts. While no BPDE-DNA adducts were detected, other unknown lipophilic adducts were seen in blood and follicular fluid. Women who failed to achieve pregnancy had higher DNA adducts in follicular fluid than those who succeeded (p < 0.05). Follicular fluid cotinine levels were associated with DNA adduct levels in blood and follicular fluid (p < 0.05). Evaluation of DNA damage resulting from oxidative stress could have a role in predicting IVF success rate. © 2009 Springer Science+Business Media, LLC.

AB - This study is designed to investigate the impact of DNA damage on pregnancy and fertilization rate outcome in a sub-sample of women undergoing IVF treatment. Blood and follicular fluid samples (n = 60) were analyzed for DNA adducts. While no BPDE-DNA adducts were detected, other unknown lipophilic adducts were seen in blood and follicular fluid. Women who failed to achieve pregnancy had higher DNA adducts in follicular fluid than those who succeeded (p < 0.05). Follicular fluid cotinine levels were associated with DNA adduct levels in blood and follicular fluid (p < 0.05). Evaluation of DNA damage resulting from oxidative stress could have a role in predicting IVF success rate. © 2009 Springer Science+Business Media, LLC.

KW - P-Postlabeling technique

KW - DNA adducts

KW - Fertilization rate

KW - In vitro fertilization

KW - Pregnancy outcome

KW - Saudi Arabia

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DO - 10.1007/s00128-009-9889-z

M3 - Article

SN - 0007-4861

VL - 84

SP - 23

EP - 28

JO - Bulletin of Environmental Contamination and Toxicology

JF - Bulletin of Environmental Contamination and Toxicology

IS - 1

ER -

Levels of DNA Adducts in the Blood and Follicular Fluid of Women Undergoing In Vitro Fertilization Treatment and Its Correlation with the Pregnancy Outcome

Abstract

Keywords

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