Leucocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women.

Wilson Mandala; Esther Gondwe; Malcolm E Molyneux; Jenny M. MacLennan; Calman A. MacLennan

doi:10.1111/aji.12678

Leucocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women.

Wilson Mandala
, Esther Gondwe
, Malcolm E Molyneux
, Jenny M. MacLennan
, Calman A. MacLennan

Clinical Sciences

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Problem

We investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity.

Method of study

We recruited 54 pregnant and 48 non-pregnant HIV-uninfected women and 24 pregnant and 20 non-pregnant HIV-infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups.

Results

Parturient HIV-infected and HIV-uninfected women had more neutrophils (each P<.0001), but fewer lymphocytes (P<.0001; P=.0014) than non-pregnant women. Both groups had fewer total T cells (P<.0001; P=.002) and CD8+ T cells (P<.0001; P=.014) than non-pregnant women. HIV-uninfected parturient women had fewer CD4+ and γδ T cells, B and NK cells (each P<.0001) than non-pregnant women. Lymphocyte subset percentages were not affected by pregnancy.

Conclusion

Malawian women at parturition have an increased total white cell count due to neutrophilia and an HIV-unrelated pan-lymphopenia.

Original language	English
Article number	e12678
Pages (from-to)	e12678
Journal	American Journal of Reproductive Immunology
Volume	78
Issue number	3
Early online date	6 Apr 2017
DOIs	https://doi.org/10.1111/aji.12678
Publication status	Published - 1 Sept 2017

Keywords

HIV
leukocytes
lymphocytes
parturition
pregnancy
sepsis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/aji.12678Licence: CC BY

AJRI Mandala et al 6Final published version, 352 KBLicence: CC BY

Cite this

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title = "Leucocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women.",

abstract = "ProblemWe investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity.Method of studyWe recruited 54 pregnant and 48 non-pregnant HIV-uninfected women and 24 pregnant and 20 non-pregnant HIV-infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups.ResultsParturient HIV-infected and HIV-uninfected women had more neutrophils (each P<.0001), but fewer lymphocytes (P<.0001; P=.0014) than non-pregnant women. Both groups had fewer total T cells (P<.0001; P=.002) and CD8+ T cells (P<.0001; P=.014) than non-pregnant women. HIV-uninfected parturient women had fewer CD4+ and γδ T cells, B and NK cells (each P<.0001) than non-pregnant women. Lymphocyte subset percentages were not affected by pregnancy.ConclusionMalawian women at parturition have an increased total white cell count due to neutrophilia and an HIV-unrelated pan-lymphopenia.",

keywords = "HIV, leukocytes, lymphocytes, parturition, pregnancy, sepsis",

author = "Wilson Mandala and Esther Gondwe and Molyneux, \{Malcolm E\} and MacLennan, \{Jenny M.\} and MacLennan, \{Calman A.\}",

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doi = "10.1111/aji.12678",

language = "English",

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journal = "American Journal of Reproductive Immunology",

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TY - JOUR

T1 - Leucocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women.

AU - Mandala, Wilson

AU - Gondwe, Esther

AU - Molyneux, Malcolm E

AU - MacLennan, Jenny M.

AU - MacLennan, Calman A.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - ProblemWe investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity.Method of studyWe recruited 54 pregnant and 48 non-pregnant HIV-uninfected women and 24 pregnant and 20 non-pregnant HIV-infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups.ResultsParturient HIV-infected and HIV-uninfected women had more neutrophils (each P<.0001), but fewer lymphocytes (P<.0001; P=.0014) than non-pregnant women. Both groups had fewer total T cells (P<.0001; P=.002) and CD8+ T cells (P<.0001; P=.014) than non-pregnant women. HIV-uninfected parturient women had fewer CD4+ and γδ T cells, B and NK cells (each P<.0001) than non-pregnant women. Lymphocyte subset percentages were not affected by pregnancy.ConclusionMalawian women at parturition have an increased total white cell count due to neutrophilia and an HIV-unrelated pan-lymphopenia.

AB - ProblemWe investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity.Method of studyWe recruited 54 pregnant and 48 non-pregnant HIV-uninfected women and 24 pregnant and 20 non-pregnant HIV-infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups.ResultsParturient HIV-infected and HIV-uninfected women had more neutrophils (each P<.0001), but fewer lymphocytes (P<.0001; P=.0014) than non-pregnant women. Both groups had fewer total T cells (P<.0001; P=.002) and CD8+ T cells (P<.0001; P=.014) than non-pregnant women. HIV-uninfected parturient women had fewer CD4+ and γδ T cells, B and NK cells (each P<.0001) than non-pregnant women. Lymphocyte subset percentages were not affected by pregnancy.ConclusionMalawian women at parturition have an increased total white cell count due to neutrophilia and an HIV-unrelated pan-lymphopenia.

KW - HIV

KW - leukocytes

KW - lymphocytes

KW - parturition

KW - pregnancy

KW - sepsis

U2 - 10.1111/aji.12678

DO - 10.1111/aji.12678

M3 - Article

SN - 1046-7408

VL - 78

SP - e12678

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

IS - 3

M1 - e12678

ER -

Leucocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women.

Abstract

Keywords

UN SDGs

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