Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients.

Altaf A Kondkar; Nikhil B Edward; Hatem Kalantan; Abdullah S Al-Kharashi; Saleh Altuwaijri; Gamal Mohamed; Tahira Sultan; Taif A Azad; Khaled K Abu-Amero

doi:10.1186/s12952-017-0068-1

Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients.

Altaf A Kondkar, Nikhil B Edward, Hatem Kalantan, Abdullah S Al-Kharashi, Saleh Altuwaijri, Gamal Mohamed, Tahira Sultan, Taif A Azad, Khaled K Abu-Amero

International Public Health

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background

To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).

Method

The study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man® assay.

Results

The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05). Overall, both the genotype and allele frequencies were not significantly different between cases and controls. The minor ‘C’ allele frequency was 49.4%, which was comparable to the Japanese population and higher than the Indian and Afro-Caribbean populations. Similarly, no significant association was found between genotypes and systemic diseases and health awareness/behavior domain variables. Importantly, glaucoma specific indices, such as intraocular pressure, cup/disc ratio and number of anti-glaucoma medication, also showed no statistically significant effect of genotypes within POAG cases.

Conclusion

Polymorphism rs540782 is not a risk factor for POAG in the Saudi cohort.

Original language	English
Article number	3
Journal	Journal of negative results in biomedicine
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12952-017-0068-1
Publication status	Published - 2 Feb 2017

Keywords

Middle-east
POAG
rs540782
ZP4

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10.1186/s12952-017-0068-1Licence: CC BY

J Neg Res BioMed 16 3Final published version, 347 KBLicence: CC BY

Cite this

@article{961575a10cc64701a461ad00fccb07ed,

title = "Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients.",

abstract = "BackgroundTo investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).MethodThe study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man{\textregistered} assay.ResultsThe genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05). Overall, both the genotype and allele frequencies were not significantly different between cases and controls. The minor {\textquoteleft}C{\textquoteright} allele frequency was 49.4\%, which was comparable to the Japanese population and higher than the Indian and Afro-Caribbean populations. Similarly, no significant association was found between genotypes and systemic diseases and health awareness/behavior domain variables. Importantly, glaucoma specific indices, such as intraocular pressure, cup/disc ratio and number of anti-glaucoma medication, also showed no statistically significant effect of genotypes within POAG cases.ConclusionPolymorphism rs540782 is not a risk factor for POAG in the Saudi cohort.",

keywords = "Middle-east, POAG, rs540782, ZP4",

author = "Kondkar, \{Altaf A\} and Edward, \{Nikhil B\} and Hatem Kalantan and Al-Kharashi, \{Abdullah S\} and Saleh Altuwaijri and Gamal Mohamed and Tahira Sultan and Azad, \{Taif A\} and Abu-Amero, \{Khaled K\}",

year = "2017",

month = feb,

day = "2",

doi = "10.1186/s12952-017-0068-1",

language = "English",

volume = "16",

journal = "Journal of negative results in biomedicine",

issn = "1477-5751",

publisher = "BioMed Central Ltd",

number = "1",

}

TY - JOUR

T1 - Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients.

AU - Kondkar, Altaf A

AU - Edward, Nikhil B

AU - Kalantan, Hatem

AU - Al-Kharashi, Abdullah S

AU - Altuwaijri, Saleh

AU - Mohamed, Gamal

AU - Sultan, Tahira

AU - Azad, Taif A

AU - Abu-Amero, Khaled K

PY - 2017/2/2

Y1 - 2017/2/2

N2 - BackgroundTo investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).MethodThe study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man® assay.ResultsThe genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05). Overall, both the genotype and allele frequencies were not significantly different between cases and controls. The minor ‘C’ allele frequency was 49.4%, which was comparable to the Japanese population and higher than the Indian and Afro-Caribbean populations. Similarly, no significant association was found between genotypes and systemic diseases and health awareness/behavior domain variables. Importantly, glaucoma specific indices, such as intraocular pressure, cup/disc ratio and number of anti-glaucoma medication, also showed no statistically significant effect of genotypes within POAG cases.ConclusionPolymorphism rs540782 is not a risk factor for POAG in the Saudi cohort.

AB - BackgroundTo investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).MethodThe study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man® assay.ResultsThe genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05). Overall, both the genotype and allele frequencies were not significantly different between cases and controls. The minor ‘C’ allele frequency was 49.4%, which was comparable to the Japanese population and higher than the Indian and Afro-Caribbean populations. Similarly, no significant association was found between genotypes and systemic diseases and health awareness/behavior domain variables. Importantly, glaucoma specific indices, such as intraocular pressure, cup/disc ratio and number of anti-glaucoma medication, also showed no statistically significant effect of genotypes within POAG cases.ConclusionPolymorphism rs540782 is not a risk factor for POAG in the Saudi cohort.

KW - Middle-east

KW - POAG

KW - rs540782

KW - ZP4

U2 - 10.1186/s12952-017-0068-1

DO - 10.1186/s12952-017-0068-1

M3 - Article

SN - 1477-5751

VL - 16

JO - Journal of negative results in biomedicine

JF - Journal of negative results in biomedicine

IS - 1

M1 - 3

ER -

Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients.

Abstract

Keywords

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