Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study

Huanyuan Luo; Dorothée Camilleri; Ibon Garitaonandia; Dilshat Djumanov; Tao Chen; Ulrike Lorch; Jörg Täubel; Duolao Wang

doi:10.1016/j.diagmicrobio.2021.115537

Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study

Huanyuan Luo, Dorothée Camilleri, Ibon Garitaonandia, Dilshat Djumanov, Tao Chen, Ulrike Lorch, Jörg Täubel, Duolao Wang

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We aim to study kinetics of anti-SARS-CoV-2 IgG antibody levels in subjects with COVID-19 for up to 11 months and the potential influential factors. The study was a prospective longitudinal study. The analyses were based on 77 serum/plasma samples with a mean of 4 samples per participant (range 1 – 18) in 20 participants with at least one positive Polymerase Chain Reaction testing result from 19 March 2020 up to 10 February 2021. Among the subjects (median age 34.5 years, 65% male), IgG level declined with the follow-up time (per month; geometric mean ratio [GMR] 0.73; 95% CI, 0.72 – 0.74). In a small sample of subjects from the general population with COVID-19, IgG levels declined non-linearly from month 2 to 11 with individual heterogeneity in quantity and changing speed and may be associated with gender, race and the loss of smell and taste.

Original language	English
Article number	115537
Pages (from-to)	115537
Journal	Diagnostic Microbiology and Infectious Disease
Volume	101
Issue number	4
Early online date	9 Sept 2021
DOIs	https://doi.org/10.1016/j.diagmicrobio.2021.115537
Publication status	Published - 1 Dec 2021

Keywords

antibody
coronavirus
COVID-19
IgG
kinetics
SARS-CoV-2

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10.1016/j.diagmicrobio.2021.115537

Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19Accepted author manuscript, 372 KB

Clinical characteristics, outcomes and immunity in patients with COVID-19
Luo, H. (Author), Wang, D. (Supervisor), Cuevas, L. (Supervisor), Taubel, J. (Supervisor) & Chen, T. (Supervisor), 2021
Student thesis: Doctoral thesis

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Luo, H., Camilleri, D., Garitaonandia, I., Djumanov, D., Chen, T., Lorch, U., Täubel, J., & Wang, D. (2021). Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study. Diagnostic Microbiology and Infectious Disease, 101(4), 115537. Article 115537. https://doi.org/10.1016/j.diagmicrobio.2021.115537

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title = "Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study",

abstract = "We aim to study kinetics of anti-SARS-CoV-2 IgG antibody levels in subjects with COVID-19 for up to 11 months and the potential influential factors. The study was a prospective longitudinal study. The analyses were based on 77 serum/plasma samples with a mean of 4 samples per participant (range 1 – 18) in 20 participants with at least one positive Polymerase Chain Reaction testing result from 19 March 2020 up to 10 February 2021. Among the subjects (median age 34.5 years, 65\% male), IgG level declined with the follow-up time (per month; geometric mean ratio [GMR] 0.73; 95\% CI, 0.72 – 0.74). In a small sample of subjects from the general population with COVID-19, IgG levels declined non-linearly from month 2 to 11 with individual heterogeneity in quantity and changing speed and may be associated with gender, race and the loss of smell and taste.",

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author = "Huanyuan Luo and Doroth{\'e}e Camilleri and Ibon Garitaonandia and Dilshat Djumanov and Tao Chen and Ulrike Lorch and J{\"o}rg T{\"a}ubel and Duolao Wang",

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Luo, H, Camilleri, D, Garitaonandia, I, Djumanov, D, Chen, T, Lorch, U, Täubel, J & Wang, D 2021, 'Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study', Diagnostic Microbiology and Infectious Disease, vol. 101, no. 4, 115537, pp. 115537. https://doi.org/10.1016/j.diagmicrobio.2021.115537

Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study. / Luo, Huanyuan; Camilleri, Dorothée; Garitaonandia, Ibon et al.
In: Diagnostic Microbiology and Infectious Disease, Vol. 101, No. 4, 115537, 01.12.2021, p. 115537.

Research output: Contribution to journal › Article › peer-review

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AU - Luo, Huanyuan

AU - Camilleri, Dorothée

AU - Garitaonandia, Ibon

AU - Djumanov, Dilshat

AU - Chen, Tao

AU - Lorch, Ulrike

AU - Täubel, Jörg

AU - Wang, Duolao

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AB - We aim to study kinetics of anti-SARS-CoV-2 IgG antibody levels in subjects with COVID-19 for up to 11 months and the potential influential factors. The study was a prospective longitudinal study. The analyses were based on 77 serum/plasma samples with a mean of 4 samples per participant (range 1 – 18) in 20 participants with at least one positive Polymerase Chain Reaction testing result from 19 March 2020 up to 10 February 2021. Among the subjects (median age 34.5 years, 65% male), IgG level declined with the follow-up time (per month; geometric mean ratio [GMR] 0.73; 95% CI, 0.72 – 0.74). In a small sample of subjects from the general population with COVID-19, IgG levels declined non-linearly from month 2 to 11 with individual heterogeneity in quantity and changing speed and may be associated with gender, race and the loss of smell and taste.

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Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study

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Keywords

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Student theses

Clinical characteristics, outcomes and immunity in patients with COVID-19

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