Is the Interleukin 8 Promoter Polymorphism rs4073/-251T >A Associated With Clostridium difficile Infection?

Fabio Miyajima; Andrew Swale; J. Eunice Zhang; Ana Alfirevic; Margaret Little; Nicholas Beeching; Godfrey Smith; Ruwanthi Kolamunnage-Dona; Munir Pirmohamed

doi:10.1093/cid/ciu152

Is the Interleukin 8 Promoter Polymorphism rs4073/-251T >A Associated With Clostridium difficile Infection?

Fabio Miyajima, Andrew Swale, J. Eunice Zhang, Ana Alfirevic, Margaret Little, Nicholas Beeching, Godfrey Smith, Ruwanthi Kolamunnage-Dona, Munir Pirmohamed

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The interleukin 8 gene single-nucleotide polymorphism rs4073/–251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/–251T >A is unlikely to constitute a major risk factor for CDI.

Original language	English
Pages (from-to)	e148-e151
Journal	Clinical Infectious Diseases
Volume	58
Issue number	12
DOIs	https://doi.org/10.1093/cid/ciu152
Publication status	Published - 15 Jun 2014

Keywords

Clostridium difficile
genetic predisposition
host response
interleukin 8
meta-analysis

Access to Document

10.1093/cid/ciu152

Cite this

@article{8c347c83a5e2471bb72b2bb7e400587d,

title = "Is the Interleukin 8 Promoter Polymorphism rs4073/-251T >A Associated With Clostridium difficile Infection?",

abstract = "The interleukin 8 gene single-nucleotide polymorphism rs4073/–251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/–251T >A is unlikely to constitute a major risk factor for CDI.",

keywords = "Clostridium difficile, genetic predisposition, host response, interleukin 8, meta-analysis",

author = "Fabio Miyajima and Andrew Swale and Zhang, \{J. Eunice\} and Ana Alfirevic and Margaret Little and Nicholas Beeching and Godfrey Smith and Ruwanthi Kolamunnage-Dona and Munir Pirmohamed",

year = "2014",

month = jun,

day = "15",

doi = "10.1093/cid/ciu152",

language = "English",

volume = "58",

pages = "e148--e151",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",