Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis

Uduak Okomo; Madikay Senghore; Saffiatou Darboe; Ebrima Bojang; Akram Zaman Akramuzzaman; Mohammad Jahangir Hossain; Davis Nwakanma; Kirsty Le Doare; Kathryn E Holt; Nina Judith Hos; Joy E Lawn; Stephen D Bentley; Beate Kampmann

doi:10.1016/s2666-5247(20)30061-6

Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis

Uduak Okomo
, Madikay Senghore
, Saffiatou Darboe
, Ebrima Bojang
, Akram Zaman Akramuzzaman
, Mohammad Jahangir Hossain
, Davis Nwakanma
, Kirsty Le Doare
, Kathryn E Holt
, Nina Judith Hos
, Joy E Lawn
, Stephen D Bentley
, Beate Kampmann

Faculty of Education

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Sick newborns admitted to neonatal units in low-resource settings are at an increased risk of developing hospital-acquired infections due to poor clinical care practices. Clusters of infection, due to the same species, with a consistent antibiotic resistance profile, and in the same ward over a short period of time might be indicative of an outbreak. We used whole-genome sequencing (WGS) to define the transmission pathways and characterise two distinct outbreaks of neonatal bacteraemia in a west African neonatal unit.

Original language	English
Pages (from-to)	E119-E129
Journal	The Lancet Microbe
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/s2666-5247(20)30061-6
Publication status	Published - 3 Jul 2020

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Uduak Outbreak Bukholderia Kebsiella Lancet Microbe 01Jul2020Final published version, 815 KBLicence: CC BY-NC-ND

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Okomo, U., Senghore, M., Darboe, S., Bojang, E., Akramuzzaman, A. Z., Hossain, M. J., Nwakanma, D., Le Doare, K., Holt, K. E., Hos, N. J., Lawn, J. E., Bentley, S. D., & Kampmann, B. (2020). Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis. The Lancet Microbe, 1(3), E119-E129. https://doi.org/10.1016/s2666-5247(20)30061-6

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title = "Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis",

abstract = "Sick newborns admitted to neonatal units in low-resource settings are at an increased risk of developing hospital-acquired infections due to poor clinical care practices. Clusters of infection, due to the same species, with a consistent antibiotic resistance profile, and in the same ward over a short period of time might be indicative of an outbreak. We used whole-genome sequencing (WGS) to define the transmission pathways and characterise two distinct outbreaks of neonatal bacteraemia in a west African neonatal unit.",

author = "Uduak Okomo and Madikay Senghore and Saffiatou Darboe and Ebrima Bojang and Akramuzzaman, \{Akram Zaman\} and Hossain, \{Mohammad Jahangir\} and Davis Nwakanma and \{Le Doare\}, Kirsty and Holt, \{Kathryn E\} and Hos, \{Nina Judith\} and Lawn, \{Joy E\} and Bentley, \{Stephen D\} and Beate Kampmann",

year = "2020",

month = jul,

day = "3",

doi = "10.1016/s2666-5247(20)30061-6",

language = "English",

volume = "1",

pages = "E119--E129",

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Okomo, U, Senghore, M, Darboe, S, Bojang, E, Akramuzzaman, AZ, Hossain, MJ, Nwakanma, D, Le Doare, K, Holt, KE, Hos, NJ, Lawn, JE, Bentley, SD & Kampmann, B 2020, 'Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis', The Lancet Microbe, vol. 1, no. 3, pp. E119-E129. https://doi.org/10.1016/s2666-5247(20)30061-6

Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis. / Okomo, Uduak; Senghore, Madikay; Darboe, Saffiatou et al.
In: The Lancet Microbe, Vol. 1, No. 3, 03.07.2020, p. E119-E129.

Research output: Contribution to journal › Article › peer-review

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AU - Okomo, Uduak

AU - Senghore, Madikay

AU - Darboe, Saffiatou

AU - Bojang, Ebrima

AU - Akramuzzaman, Akram Zaman

AU - Hossain, Mohammad Jahangir

AU - Nwakanma, Davis

AU - Le Doare, Kirsty

AU - Holt, Kathryn E

AU - Hos, Nina Judith

AU - Lawn, Joy E

AU - Bentley, Stephen D

AU - Kampmann, Beate

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AB - Sick newborns admitted to neonatal units in low-resource settings are at an increased risk of developing hospital-acquired infections due to poor clinical care practices. Clusters of infection, due to the same species, with a consistent antibiotic resistance profile, and in the same ward over a short period of time might be indicative of an outbreak. We used whole-genome sequencing (WGS) to define the transmission pathways and characterise two distinct outbreaks of neonatal bacteraemia in a west African neonatal unit.

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DO - 10.1016/s2666-5247(20)30061-6

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JO - The Lancet Microbe

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Okomo U, Senghore M, Darboe S, Bojang E, Akramuzzaman AZ, Hossain MJ et al. Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis. The Lancet Microbe. 2020 Jul 3;1(3):E119-E129. doi: 10.1016/s2666-5247(20)30061-6