Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis

Uduak Okomo; Madikay Senghore; Saffiatou Darboe; Ebrima Bojang; Akram Zaman Akramuzzaman; Mohammad Jahangir Hossain; Davis Nwakanma; Kirsty Le Doare; Kathryn E Holt; Nina Judith Hos; Joy E Lawn; Stephen D Bentley; Beate Kampmann

doi:10.1016/s2666-5247(20)30061-6

Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis

Uduak Okomo, Madikay Senghore, Saffiatou Darboe, Ebrima Bojang, Akram Zaman Akramuzzaman, Mohammad Jahangir Hossain, Davis Nwakanma, Kirsty Le Doare, Kathryn E Holt, Nina Judith Hos, Joy E Lawn, Stephen D Bentley, Beate Kampmann

Faculty of Education

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Sick newborns admitted to neonatal units in low-resource settings are at an increased risk of developing hospital-acquired infections due to poor clinical care practices. Clusters of infection, due to the same species, with a consistent antibiotic resistance profile, and in the same ward over a short period of time might be indicative of an outbreak. We used whole-genome sequencing (WGS) to define the transmission pathways and characterise two distinct outbreaks of neonatal bacteraemia in a west African neonatal unit.

Original language	English
Pages (from-to)	E119-E129
Journal	The Lancet Microbe
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/s2666-5247(20)30061-6
Publication status	Published - 3 Jul 2020

Access to Document

10.1016/s2666-5247(20)30061-6Licence: CC BY-NC-ND

Uduak Outbreak Bukholderia Kebsiella Lancet Microbe 01Jul2020Final published version, 815 KBLicence: CC BY-NC-ND

Fingerprint

Dive into the research topics of 'Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis'. Together they form a unique fingerprint.

Cite this

Okomo, U., Senghore, M., Darboe, S., Bojang, E., Akramuzzaman, A. Z., Hossain, M. J., Nwakanma, D., Le Doare, K., Holt, K. E., Hos, N. J., Lawn, J. E., Bentley, S. D., & Kampmann, B. (2020). Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis. The Lancet Microbe, 1(3), E119-E129. https://doi.org/10.1016/s2666-5247(20)30061-6

@article{e06616c2811746fa8727662ba8c9efe3,

title = "Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis",

abstract = "Sick newborns admitted to neonatal units in low-resource settings are at an increased risk of developing hospital-acquired infections due to poor clinical care practices. Clusters of infection, due to the same species, with a consistent antibiotic resistance profile, and in the same ward over a short period of time might be indicative of an outbreak. We used whole-genome sequencing (WGS) to define the transmission pathways and characterise two distinct outbreaks of neonatal bacteraemia in a west African neonatal unit.",

author = "Uduak Okomo and Madikay Senghore and Saffiatou Darboe and Ebrima Bojang and Akramuzzaman, \{Akram Zaman\} and Hossain, \{Mohammad Jahangir\} and Davis Nwakanma and \{Le Doare\}, Kirsty and Holt, \{Kathryn E\} and Hos, \{Nina Judith\} and Lawn, \{Joy E\} and Bentley, \{Stephen D\} and Beate Kampmann",

year = "2020",

month = jul,

day = "3",

doi = "10.1016/s2666-5247(20)30061-6",

language = "English",

volume = "1",

pages = "E119--E129",

journal = "The Lancet Microbe",

issn = "2666-5247",

publisher = "Elsevier Ltd",

number = "3",

}

Okomo, U, Senghore, M, Darboe, S, Bojang, E, Akramuzzaman, AZ, Hossain, MJ, Nwakanma, D, Le Doare, K, Holt, KE, Hos, NJ, Lawn, JE, Bentley, SD & Kampmann, B 2020, 'Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis', The Lancet Microbe, vol. 1, no. 3, pp. E119-E129. https://doi.org/10.1016/s2666-5247(20)30061-6

Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis. / Okomo, Uduak; Senghore, Madikay; Darboe, Saffiatou et al.
In: The Lancet Microbe, Vol. 1, No. 3, 03.07.2020, p. E119-E129.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis

AU - Okomo, Uduak

AU - Senghore, Madikay

AU - Darboe, Saffiatou

AU - Bojang, Ebrima

AU - Akramuzzaman, Akram Zaman

AU - Hossain, Mohammad Jahangir

AU - Nwakanma, Davis

AU - Le Doare, Kirsty

AU - Holt, Kathryn E

AU - Hos, Nina Judith

AU - Lawn, Joy E

AU - Bentley, Stephen D

AU - Kampmann, Beate

PY - 2020/7/3

Y1 - 2020/7/3

N2 - Sick newborns admitted to neonatal units in low-resource settings are at an increased risk of developing hospital-acquired infections due to poor clinical care practices. Clusters of infection, due to the same species, with a consistent antibiotic resistance profile, and in the same ward over a short period of time might be indicative of an outbreak. We used whole-genome sequencing (WGS) to define the transmission pathways and characterise two distinct outbreaks of neonatal bacteraemia in a west African neonatal unit.

AB - Sick newborns admitted to neonatal units in low-resource settings are at an increased risk of developing hospital-acquired infections due to poor clinical care practices. Clusters of infection, due to the same species, with a consistent antibiotic resistance profile, and in the same ward over a short period of time might be indicative of an outbreak. We used whole-genome sequencing (WGS) to define the transmission pathways and characterise two distinct outbreaks of neonatal bacteraemia in a west African neonatal unit.

U2 - 10.1016/s2666-5247(20)30061-6

DO - 10.1016/s2666-5247(20)30061-6

M3 - Article

SN - 2666-5247

VL - 1

SP - E119-E129

JO - The Lancet Microbe

JF - The Lancet Microbe

IS - 3

ER -

Okomo U, Senghore M, Darboe S, Bojang E, Akramuzzaman AZ, Hossain MJ et al. Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum β-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis. The Lancet Microbe. 2020 Jul 3;1(3):E119-E129. doi: 10.1016/s2666-5247(20)30061-6